Tetsuya Kokabu
Memorial Hospital of South Bend
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Featured researches published by Tetsuya Kokabu.
Obstetrics & Gynecology | 2014
Michinori Mayama; Masato Yoshihara; Tetsuya Kokabu; Hidenori Oguchi
BACKGROUND: Hemophagocytic lymphohistiocytosis is potentially fatal. Prompt diagnosis and initiation of treatment are critical for ensuring the best possible prognosis. CASE: We present a case of parvovirus B19 infection related to hemophagocytic lymphohistiocytosis during pregnancy. The patient experienced fever and pancytopenia. A bone marrow biopsy demonstrated hemophagocytosis and a giant proerythroblasts, which is characteristic of a parvovirus B19 infection. Viral serology for parvovirus B19 was positive. Prompt treatment was started because of the high level of certainty of viral-associated hemophagocytic lymphohistiocytosis, and the patient was successfully treated with prednisolone administration. She delivered a healthy newborn without any complications. CONCLUSION: Hemophagocytic lymphohistiocytosis should be considered when encountering unexplained cytopenia and fever. Prednisolone was an effective treatment.
Critical Care | 2015
Masato Yoshihara; Kaname Uno; Sho Tano; Michinori Mayama; Mayu Ukai; Shinya Kondo; Tetsuya Kokabu; Yasuyuki Kishigami; Hidenori Oguchi
IntroductionRecombinant human soluble thrombomodulin (rhTM) is a novel anti-coagulant agent that regulates the imbalanced coagulation system by reducing the excessive activation of thrombin. rhTM potentially reduces the morbidity and mortality in patients with sepsis-induced disseminated intravascular coagulation (DIC). However, the efficacy of rhTM in obstetric DIC has not yet been established. We performed this study to examine whether the administration of rhTM was a potentially effective treatment for DIC induced by one or more underlying obstetric disorders.MethodsThis is a single-center, retrospective cohort study conducted between January 2007 and February 2015 using the records of the Department of Obstetrics at the Perinatal Medical Center of TOYOTA Memorial Hospital, Aichi, Japan. The eligibility criteria were known or suspected obstetric DIC documented on the basis of clinical and laboratory data and association with one or more major underlying obstetric disorders. Baseline imbalance between patients with and without treatment of rhTM was adjusted using an inverse probability of treatment weighting using propensity scores composed of the following independent variables: severe postpartum hemorrhage, placental abruption, and preeclampsia/eclampsia, including hemolysis, elevated liver enzymes, and low platelet syndrome, initial platelet counts, D-dimer levels, fibrinogen levels, and prothrombin time–international normalized ratio (PT–INR). We evaluated laboratory changes and clinical outcomes in the early phase of obstetric DIC.ResultsIn total, 66 of 4627 patients admitted to our department during the study period fulfilled the required criteria; of these, 37 and 29 patients were included in the rhTM and control group, respectively. After adjustment, treatment with rhTM was associated with significant improvements in platelet counts, D-dimer levels, fibrinogen levels, and PT–INR compared with the control group. The platelet concentrate transfusion volume was significantly lower in the rhTM treatment group (3.02 vs 6.03 units, P = 0.016). None of the adjusted group differences were statistically significant for all types of organ damage and failure.ConclusionrhTM administration was associated with clinical and laboratory improvement in patients with DIC caused by underlying obstetric conditions. Further clinical research is needed to clarify the optimal application of rhTM in each of the causative obstetric disorders.
Japanese Journal of Gynecologic and Obstetric Endoscopy | 2016
Sho Tano; Kaname Uno; Masato Yoshihara; Michinori Mayama; Mayu Ukai; Takehiko Takeda; Takuma Yamada; Shohei Iyoshi; Mae Ando; Takuji Ueno; Kazuki Shimizu; Kazutaka Nakao; Shinya Kondo; Tetsuya Kokabu; Toko Harata; Yasuyuki Kishigami; Hidenori Oguchi
Japanese Journal of Gynecologic and Obstetric Endoscopy | 2016
Shinya Kondo; Kaname Uno; Sho Tano; Masato Yoshihara; Michinori Mayama; Mayu Ukai; Tetsuya Kokabu; Takehiko Takeda; Takuma Yamada; Shohei Iyoshi; Mae Ando; Takuji Ueno; Kazuki Shimizu; Kazutaka Nakao; Toko Harata; Yasuyuki Kishigami; Hidenori Oguchi
Japanese Journal of Gynecologic and Obstetric Endoscopy | 2015
Mayu Ukai; Masato Yoshihara; Michinori Mayama; Shinya Kondo; Tetsuya Kokabu; Satoshi Kitagawa; Kaname Uno; Sho Tano; Yosuke Nishio; Toko Harata; Yasuyuki Kishigami; Hidenori Oguchi
Annals of Oncology | 2015
Yuki Miyai; Sho Tano; Kaname Uno; Masato Yoshihara; Michinori Mayama; Mayu Ukai; Shinya Kondo; Tetsuya Kokabu; Yasuyuki Kishigami; Hidenori Oguchi
Japanese Journal of Gynecologic and Obstetric Endoscopy | 2014
Michinori Mayama; Masato Yoshihara; Mayu Ukai; Natsuki Koide; Shinya Kondo; Tetsuya Kokabu; Nodoka Miyazaki; Toko Harata; Tomohiko Murase; Ryuichiro Sekiya; Kaname Uno; Sho Tano; Yosuke Nishio; Yasuyuki Kishigami; Hidenori Oguchi
Japanese Journal of Gynecologic and Obstetric Endoscopy | 2014
Masato Yoshihara; Kaname Uno; Sho Tano; Yosuke Nishio; Michinori Mayama; Mayu Ukai; Natsuki Koide; Shinya Kondo; Tetsuya Kokabu; Satoshi Kitagawa; Tomohiko Murase; Nodoka Miyazaki; Toko Harata; Ryuichiro Sekiya; Yasuyuki Kishigami; Hidenori Oguchi
Japanese Journal of Gynecologic and Obstetric Endoscopy | 2014
Tetsuya Kokabu; Masato Yoshihara; Michinori Mayama; Mayu Ukai; Natsuki Koide; Shinya Kondo; Nodoka Miyazaki; Toko Harata; Satoshi Kitagawa; Yosuke Nishio; Kaname Uno; Sho Tano; Yasuyuki Kishigami; Hidenori Oguchi
Japanese Journal of Gynecologic and Obstetric Endoscopy | 2013
Hidenori Oguchi; Yasuyuki Kishigami; Nodoka Miyazaki; Tomohiko Murase; Tetsuya Kokabu; Shinya Kondo; Mayu Ukai; Natsuki Koide; Toko Harata; Michinori Mayama; Masato Yoshihara; Satoshi Kitagawa; Haruhito Sahara