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Dive into the research topics where Tetsuya Tahara is active.

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Featured researches published by Tetsuya Tahara.


Bioorganic & Medicinal Chemistry Letters | 1995

Syntheses and biological properties of novel aza-podophyllotoxin analogs prossessing pronounced antitumor activity

Yukio Hitotsuyanagi; Keiji Yamagami; Akihiro Fujii; Yoichi Naka; Yukiyasu Ito; Tetsuya Tahara

Abstract 2,4-Diaza-4-desoxypodophyllotoxin analogs have been synthesized from substituted anilines. Some of them showed promising antitumor activities against vincristine-resistant P388 murine leukemia and B16 melanoma in vivo.


Journal of The Chemical Society, Chemical Communications | 1995

Synthesis of 2,4-diaza-4-deoxypodophyllotoxin, a new analogue of podophyllotoxin possessing antitumour activity

Yukio Hitotsuyanagi; Yoichi Naka; Keiji Yamagami; Akihiro Fujii; Tetsuya Tahara

2,4-Diaza-4-deoxypodophyllotoxin 4 and its cis analogue 14 are synthesised stereoselectively from 3,4-methylenedioxyaniline 5, and show significant activity against vincristine-resistant P-388 leukaemia in vivo.


Japanese Journal of Pharmacology | 1987

Antagonistic Activity of Etizolam on Platelet-Activating Factor In Vivo Experiments

Michio Terasawa; Hiroshi Mikashima; Tetsuya Tahara; Yutaka Maruyama


Japanese Journal of Pharmacology | 1987

An antagonistic activity of etizolam on platelet-activating factor(PAF). In vitro effects on platelet aggregation and PAF receptor binding.

Hiroshi Mikashima; Shuzo Takehara; Yoshito Muramoto; Takako Khomaru; Michio Terasawa; Tetsuya Tahara; Yutaka Maruyama


Chemical & Pharmaceutical Bulletin | 1987

PAF antagonistic activity of some thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines.

Tetsuya Tahara; Hiroshi Mikashima; Michio Terasawa; Yutaka Maruyama


Chemical & Pharmaceutical Bulletin | 1990

Comparative pharmacokinetics of sulpiride and N-((1-butyl-2-pyrrolidinyl)methyl)-2-methyl-5-sulfamoyl-2,3-dihydrobenzofuran-7-carboxamide hydrochloride, a new lipophilic substituted benzamide in rats.

Ichimaro Yamada; Hiroaki Mizuta; Kenji Ogawa; Tetsuya Tahara


Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan | 1990

[Studies on the synthesis of condensed pyridazine derivatives. I. Synthesis and benzodiazepine receptor binding studies of 2-substituted-4,4a,5,6-tetrahydrobenzo[h]cinnolin-3(2H)-ones and related compounds].

Tohru Nakao; Minoru Kawakami; Kenji Morita; Yasuto Morimoto; Shuzo Takehara; Tetsuya Tahara


Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan | 1990

[Studies on the synthesis of condensed pyridazine derivatives. II. Synthesis and anxiolytic activities of 2-aryl-4,4a,5,6-tetrahydropyridazino[4,3-c]quinolin-3(2H)-ones, 2-aryl-4a,5-dihydro-2H-(1)benzothiopyrano[4,3-c]pyridazin-3(4H)-ones, and related compounds].

Tohru Nakao; Minoru Kawakami; Kenji Morita; Minoru Obata; Yasuto Morimoto; Shuzo Takehara; Tetsuya Tahara


Chemical & Pharmaceutical Bulletin | 1990

Potential Neuroleptic Agents, N-[(2-Pyrrolidinyl)methyl]-2, 3-dihydrobenzofuran-7-carboxamide Derivatives

Tetsuya Tahara; Kiyoharu Hayano; Shu Murakami; Takemi Fukuda; Michihide Setoguchi; Kuniki Ikeda; Nobuhiro Marubayashi


Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan | 1989

Thromboxane Synthetase Inhihitors. I. Synthesis of Some Imidazolylarylmethanols and Their Inhihitory Activity on Platelet Aggregation

Mineo Tsuruda; Hiroshi Mikashima; Takanori Oe; Kazuyuki Kawasaki; Shinro Setoguchi; Yoichi Naka; Tetsuya Tahara

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Keiji Yamagami

Mitsubishi Tanabe Pharma

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Yukio Hitotsuyanagi

Tokyo University of Pharmacy and Life Sciences

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Kuniki Ikeda

National Foundation for Cancer Research

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