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Dive into the research topics where Teunis Johannes Vink is active.

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Featured researches published by Teunis Johannes Vink.


European Respiratory Journal | 2017

A European Respiratory Society technical standard: exhaled biomarkers in lung disease

Ildiko Horvath; Peter J. Barnes; Stelios Loukides; Peter J. Sterk; Marieann Högman; Anna-Carin Olin; Anton Amann; Balazs Antus; Eugenio Baraldi; Andras Bikov; Agnes W. Boots; Lieuwe D. Bos; Paul Brinkman; Caterina Bucca; Giovanna E. Carpagnano; Massimo Corradi; Simona M. Cristescu; Johan C. de Jongste; Anh Tuan Dinh-Xuan; Edward Dompeling; Niki Fens; Stephen J. Fowler; Jens M. Hohlfeld; Olaf Holz; Quirijn Jöbsis; Kim D. G. van de Kant; Hugo Knobel; Konstantinos Kostikas; Lauri Lehtimäki; Jon O. Lundberg

Breath tests cover the fraction of nitric oxide in expired gas (FENO), volatile organic compounds (VOCs), variables in exhaled breath condensate (EBC) and other measurements. For EBC and for FENO, official recommendations for standardised procedures are more than 10 years old and there is none for exhaled VOCs and particles. The aim of this document is to provide technical standards and recommendations for sample collection and analytic approaches and to highlight future research priorities in the field. For EBC and FENO, new developments and advances in technology have been evaluated in the current document. This report is not intended to provide clinical guidance on disease diagnosis and management. Clinicians and researchers with expertise in exhaled biomarkers were invited to participate. Published studies regarding methodology of breath tests were selected, discussed and evaluated in a consensus-based manner by the Task Force members. Recommendations for standardisation of sampling, analysing and reporting of data and suggestions for research to cover gaps in the evidence have been created and summarised. Application of breath biomarker measurement in a standardised manner will provide comparable results, thereby facilitating the potential use of these biomarkers in clinical practice. ERS technical standard: exhaled biomarkers in lung disease http://ow.ly/mAjr309DBOP


European Respiratory Journal | 2014

Exhaled breath metabolomics as a noninvasive diagnostic tool for acute respiratory distress syndrome

Lieuwe D. Bos; Hans Weda; Yuanyue Wang; Hugo Knobel; Tamara Mathea Elisabeth Nijsen; Teunis Johannes Vink; Aeilko H. Zwinderman; Peter J. Sterk; Marcus J. Schultz

There is a need for biological markers of the acute respiratory distress syndrome (ARDS). Exhaled breath contains hundreds of metabolites in the gas phase, some of which reflect (patho)physiological processes. We aimed to determine the diagnostic accuracy of metabolites in exhaled breath as biomarkers of ARDS. Breath from ventilated intensive care unit patients (n=101) was analysed using gas chromatography and mass spectrometry during the first day of admission. ARDS was defined by the Berlin definition. Training and temporal validation cohorts were used. 23 patients in the training cohort (n=53) had ARDS. Three breath metabolites, octane, acetaldehyde and 3-methylheptane, could discriminate between ARDS and controls with an area under the receiver operating characteristic curve (AUC) of 0.80. Temporal external validation (19 ARDS cases in a cohort of 48) resulted in an AUC of 0.78. Discrimination was insensitive to adjustment for severity of disease, a direct or indirect cause of ARDS, comorbidities, or ventilator settings. Combination with the lung injury prediction score increased the AUC to 0.91 and improved net reclassification by 1.17. Exhaled breath analysis showed good diagnostic accuracy for ARDS, which was externally validated. These data suggest that exhaled breath analysis could be used for the diagnostic assessment of ARDS. Metabolites in the breath of ventilated patients may be used to diagnose the acute respiratory distress syndrome http://ow.ly/uWHF1


Journal of Applied Physics | 1999

LITHIUM TRAPPING AT EXCESS OXYGEN IN SPUTTER-DEPOSITED A-WO3 FILMS

Teunis Johannes Vink; Erik Boonekamp; Roy Gerardus Franciscus Antonius Verbeek; Y. Tamminga

The initial stages of electrochemical intercalation of lithium in sputter-deposited tungsten oxide thin films were studied. The as-deposited films show a substantial irreversible uptake of lithium without an electrochromic effect. This trapping of lithium is associated with the presence of excess oxygen in the film. The experimental results are consistent with a reaction of lithium and interstitial oxygen to form a neutral Li2−Oi complex. Our findings are relevant for the manufacture of electrochromic devices, and the electrochemical titration method used may be applied to probe excess oxygen in other oxidic films as well.


Journal of Applied Physics | 2000

Physically trapped oxygen in sputter-deposited MoO3 films

Teunis Johannes Vink; Roy Gerardus Franciscus Antonius Verbeek; J. H. M. Snijders; Y. Tamminga

In the present study, we show that the stoichiometry of sputtered molybdenum oxide films can be changed from oxygen deficient to, more surprisingly, oxygen rich. O/Mo ratios as high as 3.2 were measured, depending on the oxygen partial pressure in the sputtering atmosphere. It is shown that a substantial part of the excess oxygen is physically trapped in the film while the remaining part is chemically bonded in the form of H2O groups. The presence of physically trapped oxygen is demonstrated through a hydration reaction of the film resulting in the controlled detrapping of both excess oxygen and argon. The quantities of released oxygen are electrochemically measured and compared with the elemental composition of the film as determined by means of Rutherford backscattering spectroscopy (Mo, O, and Ar) and elastic recoil detection (H).


Clinical & Experimental Allergy | 2017

Exhaled breath profiles in the monitoring of loss of control and clinical recovery in asthma

Paul Brinkman; M. A. van de Pol; Marije G. Gerritsen; L. D. Bos; Tamara Dekker; B. S. Smids; Anirban Sinha; Christof J. Majoor; M. M. Sneeboer; Hugo Knobel; Teunis Johannes Vink; F.H.C. de Jongh; Rene Lutter; P. J. Sterk; Niki Fens

Asthma is a chronic inflammatory airway disease, associated with episodes of exacerbations. Therapy with inhaled corticosteroids (ICS) targets airway inflammation, which aims to maintain and restore asthma control. Clinical features are only modestly associated with airways inflammation. Therefore, we hypothesized that exhaled volatile metabolites identify longitudinal changes between clinically stable episodes and loss of asthma control.


Journal of Breath Research | 2015

Levels of cytokines in broncho-alveolar lavage fluid, but not in plasma, are associated with levels of markers of lipid peroxidation in breath of ventilated ICU patients.

Margit Boshuizen; Jan Hendrik Leopold; Tetyana Zakharkina; Hugo Knobel; Hans Weda; Tamara Mathea Elisabeth Nijsen; Teunis Johannes Vink; Peter J. Sterk; Marcus J. Schultz; Lieuwe D. Bos

Alkanes and alkenes in the breath are produced through fatty acid peroxidation, which is initialized by reactive oxygen species. Inflammation is an important cause and effect of reactive oxygen species. We aimed to evaluate the association between fatty acid peroxidation products and inflammation of the alveolar and systemic compartment in ventilated intensive care unit (ICU) patients.Volatile organic compounds were measured by gas chromatography and mass spectrometry in the breath of newly ventilated ICU patients within 24 h after ICU admission. Cytokines were measured in non-directed bronchial lavage fluid (NBL) and plasma by cytometric bead array. Correlation coefficients were calculated and presented in heatmaps.93 patients were included. Peroxidation products in exhaled breath were not associated with markers of inflammation in plasma, but were correlated with those in NBL. IL-6, IL-8, IL-1β and TNF-α concentration in NBL showed inverse correlation coefficients with the peroxidation products of fatty acids. Furthermore, NBL IL-10, IL-13, GM-CSF and IFNγ demonstrated positive associations with breath alkanes and alkenes. Correlation coefficients for NBL cytokines were high regarding peroxidation products of n-6, n-7 and particularly in n-9 fatty acids.Levels of lipid peroxidation products in the breath of ventilated ICU patients are associated with levels of inflammatory markers in NBL, but not in plasma. Alkanes and alkenes in breath seems to be associated with an anti-inflammatory, rather than a pro-inflammatory state in the alveoli.


Journal of Breath Research | 2018

Methodological considerations for large-scale breath analysis studies: lessons from the U-BIOPRED severe asthma project

Waqar M. Ahmed; Paul Brinkman; Hans Weda; Hugo Knobel; Yun Xu; Tamara Mathea Elisabeth Nijsen; Royston Goodacre; Nicholas J. W. Rattray; Teunis Johannes Vink; Marco Santonico; Giorgio Pennazza; Paolo Montuschi; Peter J. Sterk; Stephen J. Fowler

Methods for breath sampling and analysis require robust quality assessment to minimise the risk of false discoveries. Planning large-scale multi-site breath metabolite profiling studies also requires careful consideration of systematic and random variation as a result of sampling and analysis techniques. In this study we use breath sample data from the recent U-BIOPRED cohort to evaluate and discuss some important methodological considerations such as batch variation and correction, variation between sites, storage and transportation, as well as inter-instrument analytical differences. Based on this we provide a summary of recommended best practices for new large scale multi-site studies.


The Journal of Allergy and Clinical Immunology | 2007

An electronic nose in the discrimination of patients with asthma and controls

Silvano Dragonieri; Robert Schot; Bart Mertens; Saskia le Cessie; Stefanie A. Gauw; Antonio Spanevello; Onofrio Resta; Nico Willard; Teunis Johannes Vink; Klaus F. Rabe; Elisabeth H. Bel; Peter J. Sterk


Archive | 2004

Optical nanowire biosensor based on energy transfer

Teunis Johannes Vink; Liesbeth Van Pieterson


Sensors and Actuators B-chemical | 2012

Electronic noses calibration procedure in the context of a multicentre medical study

Marco Santonico; Giorgio Pennazza; R. Capuano; Christian Falconi; Teunis Johannes Vink; Hugo Knobel; Mp van der Schee; Peter J. Sterk; Paolo Montuschi; Arnaldo D’Amico

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Giorgio Pennazza

Università Campus Bio-Medico

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Marco Santonico

University of Rome Tor Vergata

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