Thanh Thuong Nguyen

New solid-phase for automated synthesis of oligonucleotides containing an amino-alkyl linker at their 3'-end

Abstract Immobilization of an aliphatic amino-alcohol on a 2,2′-dithiodiethanol derivatized support via a carbamate linkage formation allows automated synthesis of oligonucleotides involving amino-alkyl derivatizations at their 3′-end.

Synthesis and physicochemical studies of partially phosphate-methylated oligodeoxyribonucleotides

Abstract Partially phosphate-methylated oligodeoxyribonucleotides have been synthesized on an oxalyl-CPG derivatized support using an isopropoxyacetyl group for the protection of the exocyclic amine of the nucleic bases. Hybridization properties with the target sequence have been studied by absorption spectroscopy.