Thays Teixeira De Souza

Geographic Tongue and Fissured Tongue in 348 Patients with Psoriasis: Correlation with Disease Severity

Geographic tongue (GT) and fissured tongue (FT) are the more frequent oral lesions in patients with psoriasis. The aims of this study were to compare the prevalence of GT/FT between psoriasis group (PG) and healthy controls (HC) and investigate the correlation between GT/FT and psoriasis severity using the PASI and age of psoriasis onset. Three hundred and forty-eight PG and 348 HC were selected. According to the age of psoriasis onset, the individuals were classified as having early psoriasis and late psoriasis. The severity of vulgaris psoriasis was determined according to PASI. A follow-up was conducted in patients with psoriasis vulgaris (PV) with GT to evaluate the progression of oral and cutaneous lesions. The FT and GT were more frequent in PG than in HC. The incidence of GT was higher in patients with early psoriasis and that of FT in late-psoriasis. There is association between psoriasis intensity and GT; and a higher monthly decrease of PASI score in patients without GT. The presence of GT and FT is higher in PG than in the HC. GT is associated with disease severity and may be a marker of the psoriasis severity.

Perfil demográfico e odontológico de pacientes atendidos no Centro Odontológico para Pacientes com Necessidades Especiais da Associação Brasileira de Odontologia - Rio de Janeiro

Objective: to evaluate the demographic and dental profile of patients with special needs met in a Reference Center in the state of Rio de Janeiro, showing their main needs and the possibility of outpatient care. Material and Methods: the sample consisted of 410 patients, from whom demographic and clinical data were obtained. All the studied variables were entered in a database for descriptive statistical analysis. Results: two hundred and twenty-seven (55%) patients were male, 70% were white, and their average age was 34 years old. Inconclusive diagnosis, followed by autism spectrum disorder and intellectual disabilities, were the most found diagnoses. Most patients (78%) was from the metropolitan region. Regarding complaints and dental procedures, the main complaint was prevention (28%), and 2,902 procedures were performed. Concerning oral hygiene habits, 264 (64%) patients did not floss and 215 (52%) underwent toothbrushing three times a day. Only 57 (14%) cases required the use of sedative methods to carry out the dental treatment. Conclusion: there is a great demand for preventive and restorative treatments for patients with special needs, highlighting the need for daily strengthening practices of oral health promotion. In addition, we can see that most treatments performed were in the outpatient level, showing that the use of appropriate approach is essential for dental management, thus demystifying the care of these patients.

Variable expressivity and novel PTEN mutations in Cowden syndrome

Cowden syndrome (CS) is a phosphatase and tensin homolog gene (PTEN)-associated condition characterized by multiple mucocutaneous hamartomas and an increased risk of malignancies. We reported an isolated case and another of several individuals in one family affected by CS. The isolated case showed typical features, including fibrocystic breast disease, benign thyroid nodules, and multiple papillomatous lesions in the face and oral cavity, and the cause was a novel nonsense mutation-guanine (G) to thymine (T) transition at position 940 (c.940 G>T)-in PTEN. In the family, the proband showed erythema nodosum, duodenal ulcer, intestinal polyps, cervical lipoma, renal cysts, and glaucoma, whereas multiple members of her family were found to have intestinal polyps, and a sister had been diagnosed with breast cancer at early age. An intronic mutation-T>G transition at the +32 position of intron 8 (c.1026+32 T>G)-was found in this family, with in silico analysis revealing the creation of a new donor splice site. This study confirmed the involvement of PTEN in CS and the variable clinical expressivity of disease.