Thiago Cezar Fujita
Universidade Estadual de Londrina
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Featured researches published by Thiago Cezar Fujita.
Journal of Clinical Laboratory Analysis | 2009
Karen Brajão de Oliveira; Julie Massayo Maeda Oda; Júlio C. Voltarelli; Thiago Franco Nasser; Mario Augusto Ono; Thiago Cezar Fujita; Tiemi Matsuo; Maria Angelica Ehara Watanabe
Chemokines and their receptors regulate the trafficking of immune cells during their development, inflammation, and tissue repair. The single‐nucleotide polymorphism (SNP) rs1801157 (previously known as CXCL12‐A/ stromal cell‐derived factor‐1 (SDF1)‐3′A) in CXCL12/SDF1 gene was assessed in breast cancer, Hodgkins lymphoma (HL), and non‐Hodgkins lymphoma (NHL), since the chemokine CXCL12, previously known as SDF1, and its receptor CXCR4 regulate leukocyte trafficking and many essential biological processes, including tumor growth, angiogenesis, and metastasis of different types of tumors. Genotyping was performed by PCR‐RFLP (polymerase chain reaction followed by restriction fragment length polymorphism) using a restriction enzyme HpaII cleavage. No significant difference was observed in genotype distribution between breast cancer patients (GG: 57.3%; GA: 39.8%; AA: 2.9%) and healthy female controls (GG: 62.9%; GA: 33%; AA: 4.1%) nor between HL patients (GG: 61.1%; GA:27.8%; AA: 11.1%) and healthy controls (GG: 65.6%; GA: 28.9%; AA: 5.5%), whereas a significant difference was observed in genotype distribution between NHL patients (GG: 51.4%; GA: 47.1%; AA: 1.5%) and healthy controls (GG: 65.6%; GA: 28.9%; AA: 5.5%). Further studies will be necessary to elucidate the cancer chemokine network. However, this study suggests that CXCL12 rs1801157 polymorphism may have important implications in the pathogenesis of NHL. J. Clin. Lab. Anal. 23:387–393, 2009.
International Journal of Cancer | 2016
Patricia Midori Murobushi Ozawa; Carolina Batista Ariza; Cintya Mayumi Ishibashi; Thiago Cezar Fujita; Bruna Karina Banin-Hirata; Julie Massayo Maeda Oda; Maria Angelica Ehara Watanabe
Chemokines and its receptors have significant impact on physiological and pathological processes and studies concerning their association with tumor biology are subject of great interest in scientific community. CXCL12/CXCR4 axis has been widely studied due to its significant role in tumor microenvironment, but it is also important to development and maintenance of tissues and organs, for example, in the brain and cerebellum. Studies have demonstrated that CXCL12 and CXCR4 are required for normal cerebellar development and that dysfunction in this pathway may be involved with medulloblastoma pathogenesis. In this context, a new molecular subgroup has been suggested based on the importance of the association between CXCR4 overexpression and sonic hedgehog subgroup. Treatment using CXCR4 antagonists showed significant results, evidencing the important role and possible therapeutic capacity of CXCR4 in MB. This review summarizes studies on MB cell biology, focusing on a chemokine‐receptor axis, CXCL12/CXCR4, that may have implications for treatment strategies once it can improve life expectancy and reduce neurocognitive sequelae of patients with this neoplasia.
Brazilian Archives of Biology and Technology | 2012
Luiz Antonio Custodio; Alexandre Yukio Saito; Marla Karine Amarante; Thiago Cezar Fujita; Aparecida de Lourdes Perim; Ivete Conchon Costa; Ionice Felipe; Shiduca Itow Jankevicius
In the present study, nasal mucus from patients with leprosy were analyzed by PCR using specific primers for Lsr2 gene of Mycobacterium leprae. The presence of Lsr2 gene in the nasal mucus was detected in 25.80% of patients with paucibacillari leprosy, and 23.07% of contacts. Despite the absence of clinical features in the contact individuals, it was possible to detect the presence of Lsr2 gene in the nasal mucus of these individuals. Therefore, PCR detection of M. leprae targeting Lsr2 gene using nasal mucus samples could contribute to early diagnosis of leprosy.
Semina-ciencias Agrarias | 2011
Julie Massayo Maeda Oda; Thiago Cezar Fujita; Amanda de Fáveri Pitz; Marlusa Karlen Amarante; Ionice Felipe; Halha Ostrensky Saridakis; José Maurício Sforcin; Maria Angelica Ehara Watanabe; Ivete Conchon Costa
Revista de Patologia Tropical | 2015
Matheus Azevedo Barbosa; Leônidas Gomes Angelin; Gustavo Issamu Asai Saikawa; Cayo Julius Cesar de Oliveira; Suelen Santos da Silva; Jeanne Weber Vendruscolo; Poliana Camila Marinello; Thiago Cezar Fujita; Sérgio Paulo Dejato da Rocha; Maria Angelica Ehara Watanabe; Regina Mitsuka-Breganó; Idessania Nazareth Costa
Current Immunology Reviews | 2016
Carlos Hiroji Hiroki; Rafaela P. Erthal; Ana Paula Lombardi Pereira; Letícia M. Pacholak; Thiago Cezar Fujita; Poliana Camila Marinello; Idessânia N. Costa; Sérgio Paulo Dejato da Rocha; Maria Angelica Ehara Watanabe; Carlos Eduardo Coral de Oliveira
Biosaúde | 2016
Luiz Antonio Custodio; Heloyse Hott Paulino; Claudete Stábile Ribeiro; Alexandre Yukio Saito; Marla Karine Amarante; Julie Massayo Maeda Oda; Thiago Cezar Fujita; Ivete Conchon Costa
Anticancer Research | 2016
Guilherme Cesar Martelossi Cebinelli; Nathália De Sousa Pereira; Michelle Mota Sena; Carlos Eduardo Coral de Oliveira; Thiago Cezar Fujita; Sérgio Paulo Dejato da Rocha; Francisco José de Abreu Oliveira; Poliana Camila Marinello; Maria Angelica Ehara Watanabe
International Journal of Cancer Therapy and Oncology | 2015
Thiago Cezar Fujita; Glauco Akelinghton Freire Vitiello; Marla Karine Amarante; Carlos Eduardo Coral de Oliveira; Bruna Karina Banin Hirata; Julie Massayo Maeda Oda; Luis Turkowski; Maria Angelica Ehara Watanabe
Archive | 2013
Vânia Darc de Castro; Karina de Almeida Gualtieri; Alexandre Yukio Saito; Roberto Iemitsu Tatakihara; Julie Massayo; Maeda Oda; Luiz Antonio Custodio; Pedro Sebastião Raimundo; Dionizio Filho; Jair Tonon; Thiago Cezar Fujita; Leandra Fiori Lopes; Marla Karine Amarante