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Featured researches published by Thierry Malfroot.


Tetrahedron Letters | 1987

2,2'-Carbonyl-bis(3,5-dioxo-4-methyl-1,2,4-oxadiazolidine). I: A new reagent for the preparation of carbamates and amides, application to the synthesis of dipeptides

Michel Denarie; Denis Grehouillat; Thierry Malfroot; Jean-Pierre Senet; Gérard Sennyey; Patrick Wolf

Abstract 2,2′-Carbonyl bis(3,5-dioxo-4-methyl-1,2,4-oxadiazolidine) was prepared and used for the synthesis of various carbamates and dipeptides.


Journal of The Chemical Society-perkin Transactions 1 | 1984

Nuclear magnetic resonance studies of iminium salts. Part 11. Anionic participation of iminium salts in Phosgenation reactions

Jean R. Gauvreau; Gerard J. Martin; Thierry Malfroot; Jean Pierre Senet

Iminium salts act as catalysts in the reaction of phosgene and phenols or thiols to yield chloroformates, which are important synthetic intermediates. This effect is explained in terms of the nucleophilicity of the chloride anion of the salts on the basis of an n.m.r. identification of various intermediates. The mechanism of nucleophilic assistance of iminium salts towards the substrate can be understood as an increase of the nucleophilicity of phenol or thiol by proton abstraction from the OH or SH group by the chloride anion.


Journal of Organic Chemistry | 1984

A new reagent for the selective, high-yield N-dealkylation of tertiary amines: improved syntheses of naltrexone and nalbuphine

R. A. Olofson; Jonathan T. Martz; Jean Pierre Senet; Marc Piteau; Thierry Malfroot


Journal of Organic Chemistry | 1990

An efficient synthesis of some substituted vinylic chloroformates : reaction scope and limitations

Mark P. Bowman; Jean Pierre Senet; Thierry Malfroot; R. A. Olofson


Archive | 1986

Process for preparing carboxylic-acid chlorides by phosgenation of carboxylic acids, and catalysts for this process

Jean-Pierre Senet; Patricia Gauthier; Thierry Malfroot; Patrick Wolf


Archive | 1984

Process for the preparation of alpha-chlorinated chloroformiates

Thierry Malfroot; Jean-Pierre Senet


Journal of Organic Chemistry | 1990

2,2-Dichlorovinyl chloroformate

Mark P. Bowman; R. A. Olofson; Jean Pierre Senet; Thierry Malfroot


Archive | 1984

Dealkylation process for tertiary amines by the use of alpha-chlorinated chloroformiates

Thierry Malfroot; Marc Piteau; Jean-Pierre Senet


Archive | 1985

Process for the preparation of 1-bromoethyl hydrocarbonyl carbonates and new 1-bromoethyl hydrocarbonyl carbonates

Thierry Malfroot; Marc Piteau; Jean-Pierre Senet


Archive | 1986

DIHALOGENO-2,2-VINYL-HALOGENO FORMATES, PROCESS FOR THEIR PREPARATION AND THEIR USES

Mark P. Bowman; R. A. Olofson; Thierry Malfroot; Jean-Pierre Senet

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R. A. Olofson

Pennsylvania State University

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Mark P. Bowman

Pennsylvania State University

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Jean Pierre Senet

Pennsylvania State University

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