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Featured researches published by Thilo Hotfiel.


Biomedizinische Technik | 2014

Introduction of a neutral shoe to assess reference values for dynamic pedobarography

Anna Katharina Kluger; Hans-Dieter Carl; Andreas Jendrissek; B. Swoboda; Thilo Hotfiel

Abstract Background: The aim of our study was to introduce a so-called “neutral shoe” as a tool to assess reference values for dynamic pedobarographic investigations. Materials and methods: Twelve healthy volunteers were asked to participate. During the first trial the participants were asked to walk with a neutral shoe (Breidbach, Germany). The second trial was performed with the running shoe “Faas 500” (Puma SE, Germany). Peak plantar pressure values were analyzed from nine foot regions using the Pedar® X system (Novel Inc., Munich, Germany). Results: The mean peak pressure reduction for the total foot was 36% under the left (non-preferred) foot and 32% for the right (preferred) foot. A statistically significant reduction of peak pressure was observed for eight regions, from a mean 14% peak pressure reduction under the right metatarsal head 1 up to a 41% peak pressure reduction under the right big toe. Conclusions: The neutral shoe is a feasible tool to assess reference values for dynamic pedobarography. Such a reference tool may help to standardise several steps in the development and construction of shoes and orthotic devices.


Journal of Strength and Conditioning Research | 2017

Acute Effects of Lateral Thigh Foam Rolling on Arterial Tissue Perfusion Determined by Spectral Doppler and Power Doppler Ultrasound

Thilo Hotfiel; B. Swoboda; Sebastian Krinner; Casper Grim; Martin Engelhardt; Michael Uder; Rafael Heiss

Abstract Hotfiel, T, Swoboda, B, Krinner, S, Grim, C, Engelhardt, M, Uder, M, and Heiss, R. Acute effects of lateral thigh foam rolling on arterial tissue perfusion determined by spectral Doppler and power Doppler ultrasound. J Strength Cond Res 31(4): 893–900, 2017—Foam rolling has been developed as a popular intervention in training and rehabilitation. However, evidence on its effects on the cellular and physiological level is lacking. The aim of this study was to assess the effect of foam rolling on arterial blood flow of the lateral thigh. Twenty-one healthy participants (age, 25 ± 2 years; height, 177 ± 9 cm; body weight, 74 ± 9 kg) were recruited from the medical and sports faculty. Arterial tissue perfusion was determined by spectral Doppler and power Doppler ultrasound, represented as peak flow (Vmax), time average velocity maximum (TAMx), time average velocity mean (TAMn), and resistive index (RI), and with semiquantitative grading that was assessed by 4 blindfolded investigators. Measurement values were assessed under resting conditions and twice after foam rolling exercises of the lateral thigh (0 and 30 minutes after intervention). The trochanteric region, mid portion, and distal tibial insertion of the lateral thigh were representative for data analysis. Arterial blood flow of the lateral thigh increased significantly after foam rolling exercises compared with baseline (p ⩽ 0.05). We detected a relative increase in Vmax of 73.6% (0 minutes) and 52.7% (30 minutes) (p < 0.001), in TAMx of 53.2% (p < 0.001) and 38.3% (p = 0.002), and in TAMn of 84.4% (p < 0.001) and 68.2% (p < 0.001). Semiquantitative power Doppler scores at all portions revealed increased average grading of 1.96 after intervention and 2.04 after 30 minutes compared with 0.75 at baseline. Our results may contribute to the understanding of local physiological reactions to self-myofascial release.


Zeitschrift Fur Rheumatologie | 2016

Pigmentierte villonoduläre Synovialitis

K. A. Jendrissek; Thilo Hotfiel; B. Swoboda; S. Söder; R. Janka

BACKGROUND Pigmented villonodular synovitis (PVNS) describes a rare disease caused by an abnormal proliferation of the synovial membrane in large and small joints. In order to achieve an optimal result of treatment it is necessary to carry out specific diagnostics and a targeted therapy approach. OBJECTIVE This article gives a review of the epidemiology, etiopathogenesis and diagnostic management of PVNS as well as presenting the current therapy and treatment recommendations. MATERIAL AND METHODS A systematic search of the literature was performed in the databank of the National Center for Biotechnology Information ( http://www.ncbi.nlm.nih.gov/pubmed ). The search targeted randomized clinical and experimental studies, systematic and non-systematic review articles, expert opinions and case reports related to PVNS, independent of the level of evidence attained by each study. RESULTS The differential diagnosis of PVNS should be considered in cases of recurrent hemorrhagic joint effusions. The cause of the disease has not yet been exactly clarified. The final diagnosis can ultimately only be confirmed by histological investigations. In order to obtain representative histological tissue samples for the diagnosis, magnetic resonance imaging (MRI) with the appropriate heme sequences should be carried out prior to taking samples. The management of PVNS is often difficult due to the high risk of recurrence depending on the various forms. In view of the high rate of recurrence, therapy should include a complete synovectomy. CONCLUSION For the surgical approach arthroscopic and open procedures have been described, which are currently controversially discussed with respect to the complication and recurrence rates. Adjuvant interventional therapy forms, such as radiosynoviorthesis are recommended to reduce the recurrence rate.


Zeitschrift Fur Rheumatologie | 2016

[Pigmented villonodular synovitis : A rare differential diagnosis of synovial joint swelling].

K. A. Jendrissek; Thilo Hotfiel; B. Swoboda; S. Söder; R. Janka

BACKGROUND Pigmented villonodular synovitis (PVNS) describes a rare disease caused by an abnormal proliferation of the synovial membrane in large and small joints. In order to achieve an optimal result of treatment it is necessary to carry out specific diagnostics and a targeted therapy approach. OBJECTIVE This article gives a review of the epidemiology, etiopathogenesis and diagnostic management of PVNS as well as presenting the current therapy and treatment recommendations. MATERIAL AND METHODS A systematic search of the literature was performed in the databank of the National Center for Biotechnology Information ( http://www.ncbi.nlm.nih.gov/pubmed ). The search targeted randomized clinical and experimental studies, systematic and non-systematic review articles, expert opinions and case reports related to PVNS, independent of the level of evidence attained by each study. RESULTS The differential diagnosis of PVNS should be considered in cases of recurrent hemorrhagic joint effusions. The cause of the disease has not yet been exactly clarified. The final diagnosis can ultimately only be confirmed by histological investigations. In order to obtain representative histological tissue samples for the diagnosis, magnetic resonance imaging (MRI) with the appropriate heme sequences should be carried out prior to taking samples. The management of PVNS is often difficult due to the high risk of recurrence depending on the various forms. In view of the high rate of recurrence, therapy should include a complete synovectomy. CONCLUSION For the surgical approach arthroscopic and open procedures have been described, which are currently controversially discussed with respect to the complication and recurrence rates. Adjuvant interventional therapy forms, such as radiosynoviorthesis are recommended to reduce the recurrence rate.


Sportverletzung-sportschaden | 2015

Kontrastmittelsonografie (CEUS) in der bildgebenden Diagnostik von Muskelverletzungen – Perfusionsdarstellung in der früharteriellen Phase

Thilo Hotfiel; Hans-Dieter Carl; B. Swoboda; Martin Engelhardt; M. Heinrich; D. Strobel; D. Wildner

BACKGROUND Ultrasound is a standard procedure widely used in the diagnostic investigation of muscle injuries and widely described in the literature. Its advantages include rapid availability, cost effectiveness and the possibility to perform a real-time dynamic examination with the highest possible spatial resolution. In the diagnostic work-up of minor lesions (muscle stiffness, muscle strain), plain ultrasound has so far been inferior to MRI. The case presented by us is an example of the possibilities offered by contrast-enhanced ultrasound (CEUS) in the imaging of muscle injuries compared with plain B-mode image ultrasound and MRI imaging of the affected region. MATERIAL/METHODS This case report is about a high-performance football player who sustained a muscle injury. He underwent an ultrasound examination (S 2000, 9L4 Probe, Siemens, Germany), which was performed simultaneously in the conventional and contrast-enhanced mode at the level of the lesion. An intravenous bolus injection of 4.8 ml of intravascular contrast agent (SonoVue(®), Bracco, Italy) was given via a cubital intravenous line. After that, the distribution of contrast agent was visualised in the early arterial phase. In addition, a plain magnetic resonance imaging scan of both thighs was performed for reference. RESULTS On conventional ultrasound, the lesion was not clearly distinguishable from neighbouring tissue, whereas contrast-enhanced ultrasound demonstrated a well delineated, circumscribed area of impaired perfusion with hypoenhancement compared with the surrounding muscles at the clinical level of the lesion in the arterial wash-in phase (0-30 sec, after intravenous administration). The MRI scan revealed an edema signal with perifascial fluid accumulation in the corresponding site. CONCLUSION The use of intravascular contrast agent enabled the sensitive detection of a minor injury by ultrasound for the first time. An intramuscular edema seen in the MRI scan showed a functional arterial perfusion impairment on ultrasound, which was sensitively detected in the early phase. Further examinations must be performed on muscle injuries of various degrees of severity in order to validate the application of this procedure and to standardise the examination process.


Zeitschrift Fur Orthopadie Und Unfallchirurgie | 2012

Die Bedeutung der Kniestreckfähigkeit für die plantare Druckverteilung

Thilo Hotfiel; H.-D. Carl; B. Swoboda; A. Jendrissek; J. Pauser

BACKGROUND Dynamic pedobarography has been used for various orthopaedic issues. There is to date a lack of studies describing possible factors of influence with regard to lower limb function. MATERIAL AND METHODS Ten healthy volunteers were asked to perform a total of six trials (12 left and right steps, data from the right foot) wearing the M.4® ACL/CL knee brace (De Royal Industries, Powell, USA) around the right knee. The limitation ranged from full extension (baseline) to an extension lag of 45 degrees. Peak pressure values were obtained from the hindfoot, midfoot, forefoot and toes with the pedar X system (novel Inc., Munich, Germany). Medians were compared with the two-tailed non-parametric Wilcoxon matched-pairs signed rank test; p-values of less than 0.05 were regarded to be statistically significant. RESULTS Our study design allows the detection of differences in foot load of 20 % baseline with a power of 80 % or more. With this setting we found no statistically significant reduction of foot load up to a 20 degree extension lag of the knee joint. The opposite hindfoot load was significantly increased with 30 degrees extension lag and significantly reduced for the opposite hindfoot with 45 degrees. CONCLUSION As can be seen from the perspective of foot load, the intact function of adjacent joints seems to compensate an extension lag of the knee joint up to 20 degrees, but hindfoot load changes significantly with 30 degrees or more, which may be clinically relevant for patients at risk of plantar ulcerations.


Orthopaedic Journal of Sports Medicine | 2017

Three-Dimensional Biomechanical Analysis of Rearfoot and Forefoot Running:

Sebastian Knorz; Felix Kluge; Kolja Gelse; Stefan Schulz-Drost; Thilo Hotfiel; Matthias Lochmann; Sebastian Krinner

Background: In the running community, a forefoot strike (FFS) pattern is increasingly preferred compared with a rearfoot strike (RFS) pattern. However, it has not been fully understood which strike pattern may better reduce adverse joint forces within the different joints of the lower extremity. Purpose: To analyze the 3-dimensional (3D) stress pattern in the ankle, knee, and hip joint in runners with either a FFS or RFS pattern. Study Design: Descriptive laboratory study. Methods: In 22 runners (11 habitual rearfoot strikers, 11 habitual forefoot strikers), RFS and FFS patterns were compared at 3.0 m/s (6.7 mph) on a treadmill with integrated force plates and a 3D motion capture analysis system. This combined analysis allowed characterization of the 3D biomechanical forces differentiated for the ankle, knee, and hip joint. The maximum peak force (MPF) and maximum loading rate (LR) were determined in their 3 ordinal components: vertical, anterior-posterior (AP), and medial-lateral (ML). Results: For both strike patterns, the vertical components of the MPF and LR were significantly greater than their AP or ML components. In the vertical axis, FFS was generally associated with a greater MPF but significantly lower LR in all 3 joints. The AP components of MPF and LR were significantly lower for FFS in the knee joint but significantly greater in the ankle and hip joints. The ML components of MPF and LR tended to be greater for FFS but mostly did not reach a level of significance. Conclusion: FFS and RFS were associated with different 3D stress patterns in the ankle, knee, and hip joint, although there was no global advantage of one strike pattern over the other. The multimodal individual assessment for the different anatomic regions demonstrated that FFS seems favorable for patients with unstable knee joints in the AP axis and RFS may be recommended for runners with unstable ankle joints. Clinical Relevance: Different strike patterns show different 3D stress in joints of the lower extremity. Due to either rehabilitation after injuries or training in running sports, rearfoot or forefoot running should be preferred to prevent further damage or injuries caused by inadequate biomechanical load. Runners with a history of knee joint injuries may benefit from FFS whereas RFS may be favorable for runners with a history of ankle joint injuries.


Journal of orthopaedic surgery | 2017

Cementless femoral components in bicondylar hybrid knee arthroplasty in patients with rheumatoid arthritis: A 10-year survivorship analysis:

Thilo Hotfiel; Hans-Dieter Carl; Teresa Eibenberger; Kolja Gelse; Julian Weiß; Andreas Jendrissek; B. Swoboda

Background: Total knee arthroplasty (TKA) has been established as a successful surgical treatment in the late stages of rheumatoid joint destruction. The purpose of this study was to review the clinical outcome and survivorship in rheumatoid arthritis (RA) patients undergoing TKA in hybrid technique with a cementless fixation of the femoral component. Methods: We analysed retrospectively 66 RA patients who underwent 72 TKAs (P.F.C. Sigma®). Mean follow-up time was 124 ± 41 months. To evaluate postoperative clinical outcome, knee injury and osteoarthritis outcome score (KOOS) and Oxford knee score (OKS) were assessed. Kaplan–Meier analysis was used to calculate survivorship. The primary outcome was revision for any reason. Results: Thirty-four patients (36 knees) died and two patients (2 knees) were lost to follow-up. Three patients (four knees) did not agree to participate. Twenty-seven patients (30 knees) were available for assessing clinical scores. The average scores were 85 ± 14 for KOOS and 34 ± 10 for OKS. In three patients (three knees), revision was necessary, including restricted range of motion (n = 1), instability (n = 1), and infection (n = 1). There were no cases of loosening in this cohort study. The survival rates were 100% at 5 years, 97.1% at 10 years (95% CI 89.0–99.2%) and 95.6% at 15 years (95% CI 86.9–98.5%). Conclusions: This study confirms that excellent clinical results and a good 10-year survivorship can be obtained with hybrid fixation technique in TKA in the unique population of RA patients.


Archive | 2016

Management of Injured Athletes at the Field

Thilo Hotfiel; Hans-Dieter Carl; Casper Grim; Martin Engelhardt

Traumatic injuries of the foot and ankle occur frequently during sports competitions and represent a wide spectrum of injuries. The on-field and side-line management to injured athletes imposes high demands on the medical practitioner. A high level of knowledge about sports and discipline specify requirements regarding biomechanic principles and the resulting injuries and overuses are absolutely essential. The on-field management should follow a standardized algorithm of assessing the injured mechanism, history and physical examination. Under high time pressure, serious decisions about the following treatment referring to the individual athlete have to be taken very quickly and have to be adapted to the aggregate of the athletes’ individual disorder, the physical examinations and the specific requirements of the sport.


The Physician and Sportsmedicine | 2018

Acoustic radiation force impulse tissue characterization of the anterior talofibular ligament: a promising noninvasive approach in ankle imaging

Thilo Hotfiel; Rafael Heiss; Rolf Janka; Raimund Forst; Martin Raithel; Christoph Lutter; Kolja Gelse; Milena Pachowsky; Tobias Golditz

ABSTRACT Objectives: The anterior talofibular ligament (ATFL) is the most frequently injured ligament during inversion strains of the ankle. The purpose of this study was to evaluate the feasibility of acoustic radiation force impulse (ARFI) elastography and to determine the in vivo mechanical properties of the ATFL in healthy athletes. Methods: Sixty healthy athletes (32 female, 28 male; 28.9 ± 2.1 years) were recruited from the medical and sports faculty. ARFI values, represented as shear wave velocities (SWVs) as well as conventional ultrasound were obtained for the ATFL in neutral ankle position. A clinical assessment was performed in which the American Orthopaedic Foot & Ankle Society (AOFAS) Ankle-Hindfoot Score and the functional ankle ability measure (FAAM) were collected. Interobserver and intraobserver reliability (repeated sessions and repeated days) were assessed using an intra class correlation coefficient (ICC) and typical error (TE) calculation in absolute (TE) and relative units as coefficient of the variation (CV). Results: SWV values of the ATFL had an average velocity of 1.79 ± 0.20 m/s for all participants, with an average of 1.72 ± 0.36 m/s for females and 1.85 ± 0.31 m/s for males. The interobserver and intraobserver reliability revealed an ICC of 0.902 and 0.933 (TE of 0.67 (CV: 5.2%) and 0.52 (CV: 3.84%)), respectively. FAAM and AOFAS revealed the best possible scores. Conclusion: ARFI seems to be a valuable diagnostic modality and represents a promising imaging marker for the assessment and monitoring of ankle ligaments in the context of acute and chronic ankle instabilities; ARFI could also be used to investigate loading or sport dependent adaptions.

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B. Swoboda

University of Erlangen-Nuremberg

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Martin Engelhardt

Goethe University Frankfurt

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Hans-Dieter Carl

University of Erlangen-Nuremberg

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Kolja Gelse

University of Erlangen-Nuremberg

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Marion Kellermann

University of Erlangen-Nuremberg

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Michael Uder

University of Erlangen-Nuremberg

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Armin M. Nagel

German Cancer Research Center

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D Wildner

University of Erlangen-Nuremberg

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Andreas Jendrissek

University of Erlangen-Nuremberg

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K. A. Jendrissek

University of Erlangen-Nuremberg

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