Thilo Patzer

Osteochondral autologous transplantation for the treatment of full-thickness articular cartilage defects of the shoulder

We describe the outcome at a mean follow-up of 8.75 years (7.6 to 9.8) of seven patients who had undergone osteochondral autologous transplantation for full-thickness cartilage defects of the shoulder between 1998 and 2000. These patients have been described previously at a mean of 32.6 months when eight were included. One patient has been lost to follow-up. The outcome was assessed by the Constant shoulder score and the Lysholm knee score to assess any donor-site morbidity. Standard radiographs and MR scores were obtained and compared with the pre-operative findings and the results from the previous review. No patient required any further surgery on the shoulder. The mean Constant score improved significantly until the final follow-up (p = 0.018). The Lysholm score remained excellent throughout. There was a significant progression of osteoarthritic changes from the initial surgery to the first and final follow-up but this did not appear to be related to the size of the defect, the number of cylinders required or the Constant score (p = 0.016). MRI showed that all except one patient had a congruent joint surface at the defect with full bony integration of all osteochondral cylinders. The results have remained satisfactory over a longer period with very good objective and subjective findings.

Biomechanical Comparison of Arthroscopically Performable Techniques for Suprapectoral Biceps Tenodesis

PURPOSE The aim of this study was to biomechanically compare the cyclic and ultimate failure load (UFL) of 4 widely used techniques for arthroscopically performable suprapectoral tenodesis of the long head of the biceps tendon (LHB). METHODS We used 28 fresh-frozen human cadaveric specimens (mean age, 65 years [range, 43 to 78 years; SD, 6.7 years]; 43% male specimens) to investigate 4 different techniques for LHB tenodesis. All techniques were performed in an open manner, with localization at the entrance of the bicipital groove. Two suture anchor techniques (Healix [DePuy Mitek, Raynham, MA], 5.5 mm, with modified lasso-loop stitch; BioSwiveLock [Arthrex, Naples, FL], 5.5 mm, with interlocking Krackow stitch) and two techniques using tenodesis screws (Bio-Tenodesis screw [Arthrex], 8 × 23 mm; Biceptor [Smith & Nephew, Andover, MA], 8 × 25 mm) were investigated. Under a 10-N preload, an axial cyclic load with 100 cycles, 1-Hz frequency, and 50-N maximum load was applied. UFL was evaluated with an axial traction of 0.2 mm/s. LHB displacement during testing was measured by 3-dimensional photogrammetry. RESULTS All techniques had a mean displacement of less than 3 mm after cyclic loading. The highest UFL was measured with the Bio-Tenodesis screw (mean, 218.3 N; range, 134.0 to 313.0 N; SD, 59.7 N) and the lowest with the BioSwiveLock (mean, 111.2 N; range, 60.0 to 156.8 N; SD, 32.3 N). The Healix had the second highest UFL (mean, 187.1 N; range, 144.7 to 245.0 N; SD, 35.5 N), followed by the Biceptor (mean, 173.9 N; range, 147.0 to 209.3 N; SD, 27.2 N). There was no significant difference between the Healix, Bio-Tenodesis screw, and Biceptor (P > .05), but the Healix and Bio-Tenodesis screw had a significantly higher UFL than the BioSwiveLock (P < .01). The failure mode was either suture cutout or failure at the anchor-suture-bone interface or of the tendon itself and was generally dependent on technique. CONCLUSIONS All techniques resisted cyclic testing without a higher grade of displacement, and all devices except the BioSwiveLock had a satisfactory UFL whereas different failure mechanisms were present. The modified lasso-loop stitch provides sufficient tendon fixation and is equivalent to interference screws. CLINICAL RELEVANCE The lasso-loop suture anchor technique is an appropriate alternative for suprapectoral LHB tenodesis compared with tenodesis screw techniques.

Physiology and pathophysiology of nitrosative and oxidative stress in osteoarthritic joint destruction

Osteoarthritis (OA) is one of the most common chronic diseases, with increasing importance due to increased life expectancy. On a cellular level, the pathophysiology of joint function impairment and ultimate destruction associated with OA remains poorly understood. Free radicals are highly reactive molecules involved in both normal intracellular signal transduction and degenerative cellular processes. An imbalance between the free radical burden and cellular scavenging mechanisms, defined as oxidative stress, has been identified as a relevant factor in OA pathogenesis. This literature review elucidates the involvement of nitrosative and oxidative stress in cellular ageing in joints, cell senescence, and apoptosis. Free radical exposure is known to promote cellular senescence and apoptosis, and the involvement of radical oxygen species (ROS) in inflammation, fibrosis control, and pain nociception has been proven. A relatively novel approach to OA pathophysiology considers the joint to be a dynamic system consisting of 3, continuously interacting compartments, cartilage, synovial tissue, and subchondral bone. Current knowledge concerning free radical involvement in paracrine signalling in OA is reviewed. The interrelationship between oxidative imbalances and OA pathophysiology may provide a novel approach to the comprehension, and therefore modification, of OA disease progression and symptom control.

Increased glenohumeral translation and biceps load after SLAP lesions with potential influence on glenohumeral chondral lesions: a biomechanical study on human cadavers.

PurposeThe aim of the study was to evaluate the stabilizing function of the long head of biceps tendon (LHB) and its tension, both without and with the presence of SLAP lesion to analyze a potentially occurring humeral chondral print of LHB with consecutive glenohumeral chondral lesions in SLAP lesions.MethodsTestings were performed on 21 fresh frozen human cadaver shoulders with intact shoulder girdle by a 5 axis industrial robot with a force/moment sensor and 20 N joint compression, 50 N force in anterior, posterior, anterosuperior, and anteroinferior direction, and 0°, 30°, 60° of abduction. LHB was connected over a force measuring sensor with 5 N and 25 N preload. A type IIC SLAP lesion was created arthroscopically.ResultsA significant increase in anterior and anteroinferior translation was evaluated, whereas the LHB tension increased significantly in at most anterior and anterosuperior direction. The highest increase in translation and LHB tension after SLAP lesion was measured in anterior translation in at most 60° of abduction.The glenohumeral translation was significantly higher in SLAP lesions without LHB tenotomy than after isolated LHB tenotomy.ConclusionsSLAP lesions lead to increased glenohumeral translation and concurrently LHB tension and load in at most anterior direction. The increased anterior glenohumeral instability and the increased LHB load pressing on the humeral head might cause glenohumeral chondral lesions with a typical chondral print-like lesion on the humeral head underneath the LHB.

The influence of superior labrum anterior to posterior (SLAP) repair on restoring baseline glenohumeral translation and increased biceps loading after simulated SLAP tear and the effectiveness of SLAP repair after long head of biceps tenotomy

HYPOTHESIS Biomechanical studies have shown increased glenohumeral translation and loading of the long head biceps (LHB) tendon after superior labrum anterior to posterior (SLAP) tears. This may explain some of the typical clinical findings, including the prevalence of humeral chondral lesions, after SLAP lesions. The first hypothesis was that SLAP repair could restore the original glenohumeral translation and reduce the increased LHB load after SLAP lesions. The second hypothesis was that SLAP repair after LHB tenotomy could significantly reduce the increased glenohumeral translation. MATERIALS AND METHODS Biomechanical testing was performed on 21 fresh frozen human cadaveric shoulders with an intact shoulder girdle using a sensor-guided industrial robot to apply 20 N of compression in the joint and 50 N translational force at 0°, 30°, and 60° of abduction. LHB loading was measured by a load-cell with 5 N and 25 N preload. Type IIC SLAP lesions were created arthroscopically, and a standardized SLAP repair was done combined with or without LHB tenotomy. RESULTS No significant difference of glenohumeral translation and increased LHB load in SLAP repair compared with the intact shoulder was observed under 5 N and 25 LHB preload, except for anterior translation under 25 N LHB preload. After LHB tenotomy after SLAP lesions, no significant difference of translation was observed with or without SLAP repair. CONCLUSIONS SLAP repair without associated LHB tenotomy helps normalize glenohumeral translation and LHB loading. The stabilizing effect of the SLAP complex is dependent on the LHB. After biceps tenotomy, SLAP repair does not affect glenohumeral translation.

Biomechanical Effectiveness of an Arthroscopic Posterior Bankart Repair Versus an Open Bone Block Procedure for Posterior Shoulder Instability

Background: The most effective surgical treatment for traumatic posterior shoulder instability remains unclear. Hypothesis: An arthroscopic posterior Bankart repair is as effective as an open posterior bone block–capsulorrhaphy procedure regarding the restoration of humeral displacement with posterior and inferior forces. Study Design: Controlled laboratory study. Methods: Biomechanical testing of 16 human shoulders was performed in 3 testing conditions: after ventilation (intact joint), after creation of a posteroinferior Bankart lesion with an additional cut of the posterior band of the inferior glenohumeral ligament, and after surgical shoulder stabilization. The shoulder stabilization was performed either by an open posterior bone block procedure and glenoid-based T-capsulorrhaphy or by an arthroscopic Bankart repair. Testing was performed in 2 positions—the sulcus test position and the jerk test position—with a passive humerus load of 50 N applied in the posterior, posteroinferior, and inferior directions. Results: After the arthroscopic repair, there was no significant difference between the translation and the intact state for all tested directions. The bone block repair–capsulorrhaphy caused a significant decrease of posterior translation (sulcus test and jerk test positions) and posteroinferior translation (jerk test position). But the resulting posterior and posteroinferior translation was even significantly lower than the translation measured for the intact joints. However, the reduction of inferior translation, compared with that of the defect condition, was not significant after the bone block repair (sulcus test and jerk test positions). Compared with that of the intact joint, inferior translation after the bone block repair was significantly higher. Conclusion: The posterior bone block repair–capsulorrhaphy overcorrects posterior translation and does not effectively restore inferior stability, whereas the arthroscopic posterior Bankart repair restores posterior and inferior laxity of the intact joint. Clinical Relevance: An arthroscopic posterior capsulolabral repair more precisely restores posterior and inferior glenohumeral joint laxity and is therefore recommended as the first choice of treatment.

All-arthroscopic suprapectoral long head of biceps tendon tenodesis with interference screw-like tendon fixation after modified lasso-loop stitch tendon securing.

Arthroscopic suprapectoral techniques for tenodesis of the long head of the biceps tendon (LHB) are appropriate for the treatment of proximal biceps lesions. Several types of techniques and fixation devices have been described and evaluated in biomechanical studies regarding primary stability. In this technical note, we describe an all-arthroscopic suprapectoral technique using the 6.25-mm Bio-SwiveLock device (Arthrex, Naples, FL) for an interference screw-like bony fixation after having armed the tendon with a lasso-loop stitch. Both the interference screw fixation and securing of the lasso-loop tendon have been well described and approved in biomechanical tests concerning the primary stability. One advantage of this technique performed from the glenohumeral space, in addition to the strong and secure fixation with ingrowth of the tendon in a bony canal, is the avoidance of touching the soft tissue above the bicipital groove, which results in a smooth fitting of the tendon into its natural canal and therefore avoids mechanical irritation of the stump at the rotator interval. In conclusion, the all-arthroscopic suprapectoral LHB tenodesis performed from the glenohumeral space with the modified lasso-loop stitch for securing of the tendon and the 6.25-mm Bio-SwiveLock suture anchor for interference screw-like bony tendon fixation is an appropriate technique for the treatment of LHB-associated lesions.

Is There an Association Between SLAP Lesions and Biceps Pulley Lesions

PURPOSE The purpose of this study was to evaluate the prevalence of SLAP and biceps reflection pulley lesions. The hypothesis was that these lesions do not occur concomitantly and they have a different etiology. METHODS We prospectively analyzed 3,395 shoulder arthroscopies that were independently performed by 2 surgeons between 2004 and 2008 regarding the prevalence of SLAP and biceps pulley lesions. Intraoperative findings were correlated with patient history and clinical examination. Exclusion criteria were type I SLAP lesions, full-thickness rotator cuff tears, and a history of shoulder dislocation. RESULTS This study included 182 patients with SLAP lesions (prevalence, 5.4%; 138 men; mean age, 47 years) and 87 patients with pulley lesions (prevalence, 2.6%; 63 men; mean age, 49 years). Isolated SLAP lesions were present in 157 cases, and isolated pulley lesions in 62 cases. The concomitant presence of a SLAP lesion and pulley lesion was significantly rare (10%, P = .003). In 55 (35%; 42 men [76%]; mean age, 43 years) of the cases with isolated SLAP lesions and 40 (65%; 27 men [68%]; mean age, 49 years) with isolated pulley lesions, there was a significant association with history of trauma (P < .01). Most SLAP lesions (32 [58%], P = .174 [not significant]) and most pulley lesions (28 [70%], P < .01) resulted from falling on the outstretched arm with external arm rotation in SLAP lesions and internal rotation in pulley lesions (P > .05). CONCLUSIONS The concomitant presence of biceps tendon-associated lesions in the form of SLAP and pulley lesions is significantly rare. A history of falling on the abducted and externally rotated arm was typical in patients with SLAP lesions, whereas a fall on the arm with internal rotation was often noted in patients with pulley lesions. LEVEL OF EVIDENCE Level IV, therapeutic case series.

Surgical and nonsurgical treatment of total rupture of the pectoralis major muscle in athletes: update and critical appraisal.

The complete rupture of the pectoralis major tendon is an uncommon injury but has become increasingly common among athletes in recent years. This may be due to a higher number of individuals taking part in high-impact sports and weightlifting as well as the use of anabolic substances, which can make muscles and tendons vulnerable to injury. In recent literature, there are only few recommendations to rely on conservative treatment alone, but there are a number of reports and case series recommending early surgical intervention. Comparing the results of the two treatment regimens, there is clear evidence for a superior outcome after surgical repair with better cosmesis, better functional results, regaining of muscle power, and return to sports compared with the conservative treatment. In summary, anatomic surgical repair is the treatment of choice for complete acute ruptures of the pectoralis major tendon or muscle in athletes.

Anterior Cruciate Ligament deficiency leads to early instability of scaffold for cartilage regeneration: a controlled laboratory ex-vivo study

PurposeThe affect of anterior cruciate ligament (ACL) integrity on the early postoperative stability of a collagen type-I gel scaffold was investigated. The value of fibrin glue for graft fixation in ACL deficient porcine knees over a simulated early postoperative period was also studied.MethodsFull-thickness articular cartilage defects (11 × 6 mm) were created on the medial femoral condyle of 80 porcine knees. The ACL was left intact or completely transected in each of 40 knees. Gel plugs were tested in each group: press-fitting only in 20 specimens and press-fitting plus fibrin glue in 20 specimens. Each knee underwent 2,000 cycles in a validated ex-vivo continuous passive motion model.ResultsPress-fit-only fixation grafts in knee specimens with an intact ACL showed significantly superior stability than that in ACL deficient knees (p = 0.01). In ACL deficient knees, grafts fixed with press-fitting plus fibrin glue showed significantly superior stability than those using press-fit only fixation (p = 0.01). Press-fitting plus fibrin glue fixation showed no significant differences in worn surface area between knee specimens with intact and deficient ACL.ConclusionsACL deficiency led to early scaffold instability in an ex-vivo porcine knee model. Fibrin glue in ACL deficient knees led to additional graft stability. These findings indicated that cartilage regenerative techniques may give optimum results in ACL intact knees.