Thomas A. Strike

Acute mortality of mice and rats exposed to 14 MeV neutrons.

Mice (C57BL and C3H) and Sprague-Dawley rats were exposed to 250 kVp x-rays or 14 MeV neutrons, and mortality data were collected for 30 days thereafter. The whole-body, bilateral x-irradiations over the range of 378-918 rads (midline tissue dose) were delivered at approximately 21 rads/minute. The whole-body rotational neutron irradiations utilized midline tissue doses in the range from 282 to 707 rads. C57BL mice and Sprague-Dawley rats were exposed at a neutron dose rate which varied from 15 to 35 rads/minute (average ∼20 rads/minute). C3H mice were exposed at 15-50 (average ∼20 rads/minute) or 3-5 rads/minute to investigate the possibility of dose-rate effects. Mortality or survival time differences were not observed between sexes, and reported values represent combined groupings. The

Effect of Ionizing Radiation on Total Protein-Bound Neutral Hexoses in the Plasma of Mice'

{\rm LD}_{50/30}

Effect of Monoenergetic 14-MeV Neutron and Mixed Gamma-Neutron Radiations on Immunoelectrophoretic Patterns of Mice

values for x-rays and 14 MeV neutrons, respectively, were: C57BL mice, 680 and 432 rads; C3H mice, 704 and 537 (3-5 rads/minute) or 480 (15-50 rads/minute); Sprague-Dawley rats, 810 and 494 rads. The r...

Alteration of Postirradiation Hypotension and Incapacitation in the Monkey by Administration of Vasopressor Drugs

Total protein-bound carbohydrates (PBC), as neutral hexoses, were quantified in the plasma of C3H mice as a function of time relative to whole-body exposure to either monoenergetic 14-MeV neutrons or mixed gamma-neutron radiations delivered at a rate of approximately 20 rads/ min. The reported doses, 365 to 530 rads, were those which yielded survivors under the stress of daily bleeding. A striking difference was observed between those radiosensitive animals which died after exposure and the more resistant individuals which, although exposed to identical doses, survived the observation period. In the former population, the PBC concentration rose to high values and remained elevated until the death of the animal. By contrast, the survivors showed little change in PBC, deviating only slightly from their preirradiation base-line values. The mean preirradiation PBC concentration in the mice which survived 30 days, while statistically significant (p < 0.01) only at the lowest reported dose, was consistently lower than that of those which died during the same period. The magnitude of the difference was inversely related to the radiation dose. The refinement of these data to provide an index to radiosensitivity prior to and prognosis after irradiation in otherwise healthy individuals is proposed.

Acute mortality of chinchillas exposed to mixed gamma-neutron radiations or 250-kVp x-rays.

Immunoelectrophoretic analyses were made on sera of C3H mice after steady-state whole-body exposures to

Effectiveness of anticonvulsants in mice exposed to mixed gamma-neutron radiations.

{\rm LD}_{20(30)}

EFFECTIVENESS OF TRANQUILIZING DRUGS IN RATS EXPOSED TO MIXED GAMMA-- NEUTRON RADIATIONS.

or

Effectiveness of Pressor Drugs in Beagles Exposed to Mixed Gamma-Neutron Radiations

{\rm LD}_{80(30)}

The effect of sympathomimetic amines on radiation-induced tolerance to pentobarbital in the rat.

doses of monoenergetic 14-MeV neutrons or mixed gamma-neutron radiations. Marked differences were seen in the

DRUG TOXICITY IN MICE EXPOSED TO MIXED GAMMA-NEUTRON RADIATIONS.

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