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Dive into the research topics where Thomas C. Cox is active.

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Featured researches published by Thomas C. Cox.


Proceedings of the National Academy of Sciences of the United States of America | 2010

Human antibodies reveal a protective epitope that is highly conserved among human and nonhuman influenza A viruses

Andres G. Grandea; Ole A. Olsen; Thomas C. Cox; Mark Renshaw; Philip Hammond; Po Ying Chan-Hui; Jennifer L. Mitcham; Witold Cieplak; Shaun M. Stewart; Michael L. Grantham; Andrew Pekosz; Maki Kiso; Kyoko Shinya; Masato Hatta; Yoshihiro Kawaoka; Matthew Moyle

Influenza remains a serious public health threat throughout the world. Vaccines and antivirals are available that can provide protection from infection. However, new viral strains emerge continuously because of the plasticity of the influenza genome, which necessitates annual reformulation of vaccine antigens, and resistance to antivirals can appear rapidly and become entrenched in circulating virus populations. In addition, the spread of new pandemic strains is difficult to contain because of the time required to engineer and manufacture effective vaccines. Monoclonal antibodies that target highly conserved viral epitopes might offer an alternative protection paradigm. Herein we describe the isolation of a panel of monoclonal antibodies derived from the IgG+ memory B cells of healthy, human subjects that recognize a previously unknown conformational epitope within the ectodomain of the influenza matrix 2 protein, M2e. This antibody binding region is highly conserved in influenza A viruses, being present in nearly all strains detected to date, including highly pathogenic viruses that infect primarily birds and swine, and the current 2009 swine-origin H1N1 pandemic strain (S-OIV). Furthermore, these human anti-M2e monoclonal antibodies protect mice from lethal challenges with either H5N1 or H1N1 influenza viruses. These results suggest that viral M2e can elicit broadly cross-reactive and protective antibodies in humans. Accordingly, recombinant forms of these human antibodies may provide useful therapeutic agents to protect against infection from a broad spectrum of influenza A strains.


Archive | 2010

Compositions and methods for the therapy and diagnosis of influenza

Andres G. Grandea; Gordon E. King; Thomas C. Cox; Ole Olsen; Jennifer L. Mitcham; Matthew Moyle; Phil Hammond


Archive | 2010

Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Neutralizing Antibodies

Po-Ying Chan-Hui; Steven Frey; Andres G. Grandea; Thomas C. Cox


Journal of Immunology | 2017

Pillars Article: An Essential Role for Scurfin in CD4+CD25+ T Regulatory Cells. Nat. Immunol. 2003. 4: 337–342

Roli Khattri; Thomas C. Cox; Sue-Ann Yasayko; Fred Ramsdell


Archive | 2012

Compositions et methodes de therapie et de diagnostic de la grippe

Andres G. Grandea; Gordon E. King; Thomas C. Cox; Ole Olsen; Jennifer L. Mitcham; Matthew Moyle; Phil Hammond


Archive | 2012

Compositions et procédés pour thérapie et diagnostic de la grippe

Andres G. Grandea; Gordon E. King; Thomas C. Cox; Ole Olsen; Jennifer L. Mitcham; Matthew Moyle; Phil Hammond


Archive | 2010

Compositions et procédés pour le traitement et le diagnostic de la grippe

Andres G. Grandea; Gordon E. King; Thomas C. Cox; Ole Olsen; Jennifer L. Mitcham; Matthew Moyle; Phil Hammond


Archive | 2010

Anticorps neutralisant le facteur de croissance des granulocytes et des macrophages (gm-csf)

Po-Ying Chan-Hui; Steven Frey; Andres G. Grandea; Thomas C. Cox


Archive | 2010

Compositions et méthodes utilisables dans le cadre du traitement et du diagnostic de la grippe

Andres G. Grandea; Gordon E. King; Thomas C. Cox; Ole Olsen; Jennifer L. Mitcham; Matthew Moyle; Phil Hammond


Journal of Immunology | 2010

Isolation of A Human GM-CSF Antibody with Potent Neutralizing Activity from a Subject with Idiopathic Pulmonary Alveolar Proteinosis

Po-Ying Chan-Hui; Thomas C. Cox; Roxanne Grondin; Glen Grandea; Steve Frey; Mark Branum; Courtney Ward; Ray Fox; Ole Olsen; Phil Hammond; Witold Cieplak; Matthew Moyle

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Matthew Moyle

International AIDS Vaccine Initiative

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Ole Olsen

University of British Columbia

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Po-Ying Chan-Hui

International AIDS Vaccine Initiative

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Masato Hatta

University of Wisconsin-Madison

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Steven Frey

International AIDS Vaccine Initiative

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Yoshihiro Kawaoka

University of Wisconsin-Madison

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Andrew Pekosz

Johns Hopkins University

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