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Featured researches published by Thomas D. Coates.


The New England Journal of Medicine | 1982

Lactoferrin Deficiency Associated with Altered Granulocyte Function

Laurence A. Boxer; Thomas D. Coates; Richard A. Haak; J. Baruch Wolach; Sylvia Hoffstein; Robert L. Baehner

EIGHT years ago Strauss et al. reported unique structural abnormalities in the granulocytes of a boy who had had recurrent bacterial infections since birth.1 The nuclei were bilobed, and in ultrast...


Cancer | 1980

Thrombotic and hemorrhagic strokes complicating early therapy for childhood acute lymphoblastic leukemia

John R. Priest; Norma K.C. Ramsay; Richard E. Latchaw; Lawrence A. Lockman; Duane K. Hasegawa; Thomas D. Coates; Peter F. Coccia; J. Roger Edson; Mark E. Nesbit; William Krivit

Sudden cerebrovascular insults occurred during or immediately following remission induction therapy in 4 children with acute lymphoblastic leukemia. In 3, cerebral infarction was due to thrombosis. In the fourth, an intracerebral hematoma developed representing either frank hemorrhaging or a hemorrhagic infarction. None of the patients had central nervous system leukemia or extreme leukocytosis at the time of diagnosis. Symptoms were obtundation, hemiparesis, seizures, and headache. The induction chemotherapy included L‐asparaginase which causes deficiencies of antithrombin, plasminogen, fibrinogen, and factors IX and XI. These hemostatic abnormalities may explain the thromboses and bleeding observed in these children.


Cancer | 1983

Effect of nutrition staging on treatment delays and outcome in stage IV neuroblastoma

Karyl A. Rickard; Catherine M. Detamore; Thomas D. Coates; Jay L. Grosfeld; Robert M. Weetman; Nancy Matchett White; Arthur J. Provisor; Laurence A. Boxer; Emily Loghmani; Tjien O. Oei; Pao‐lo ‐l Yu; Robert L. Baehner

The effect of the state of nutrition of 18 children with Stage IV neuroblastoma at diagnosis and during initial therapy, was evaluated with respect to treatment delays, drug dosage alterations, tumor response, days to first event (relapse or death), and survival. All patients received similar therapy (CCSG protocol CCG 371). Based on nutrition staging at diagnosis, nine were classified as malnourished; four were randomized to receive total parenteral nutrition (TPN) and four peripheral parenteral nutrition plus enteral nutrition for 28 days (through 2 chemotherapy courses), and one died before randomization. Nine were nourished at diagnosis; seven received a comprehensive enteral nutrition program and two received TPN. By life‐table analysis, the duration of remission was significantly greater in the nourished than the malnourished (P < 0.01) and a trend towards improved survival was evident at one year (P = 0.08). The median length of survival for children nourished at diagnosis was approximately 12 months, whereas those malnourished had a median survival of only 5 months. Nine children remained nourished or were becoming renourished during the first 21 days of therapy, and one of these had treatment delays and decreased drug dosages. Seven were becoming malnourished or remained malnourished during this period and six had treatment delays (P < 0.01). These data support the idea that nutrition staging at diagnosis and during initial treatment should be an integral part of protocol design and initial evaluation of children with Stage IV neuroblastoma.


Cancer | 1985

Short- and long-term effectiveness of enteral and parenteral nutrition in reversing or preventing protein-energy malnutrition in advanced neuroblastoma a prospective randomized study

Karyl A. Rickard; Emily Loghmani; Jay L. Grosfeld; Catherine Detamore Lingard; Nancy Matchett White; Beth Bartlett Foland; Barbara L. Jaeger; Thomas D. Coates; Pao-Lo Yu; Robert M. Weetman; Arthur J. Provisor; Tjien O. Oei; Robert L. Baehner

The effectiveness of enteral and parenteral nutrition regimens in preventing or reversing protein–energy malnutrition (PEM) and in preventing treatment delays was evaluated in 32 children receiving treatment for newly diagnosed Stage III (3 patients) and IV (29 patients) neuroblastoma. Ten of 18 malnourished patients were randomized to central parenteral nutrition (CPN) and 8 to peripheral parenteral nutrition (PPN) plus enteral nutrition for 4 weeks and then received enteral nutrition (EN: intense nutrition counselling, oral foods and supplements) for weeks 5 through 10. Ten of 14 nourished patients received EN and 4 CPN for 4 weeks and EN thereafter. Dietary, anthropometric and biochemical measurements were determined for weeks 0, 1, 2, 3, 4, 7, and 10 for 24 patients who completed the protocols. In malnourished patients, both CPN (seven patients) and PPN (seven patients) were effective in reversing PEM in the first 4 weeks; thereafter, EN effectively maintained nutritional gains in both groups. In nourished patients, EN (seven patients) was not as effective as CPN (three patients) in preventing PEM during the first 4 weeks; afterwards, EN maintained gains in the CPN group but did not promote needed increases in weight nor fat reserves in the EN group. Patients supported by parenteral nutrition (PN, weeks 1–4) had fewer treatment delays (2/17, 12%) than EN patients (4/7, 57%, P <0.05). These data indicate that PN reverses or prevents PEM and prevents treatment delays during the first 4 weeks of intense oncologic treatment and provides nutritional benefits which can be maintained with EN thereafter.


Cancer | 1986

The value of nutrition support in children with cancer

Karyl A. Rickard; Thomas D. Coates; Jay L. Grosfeld; Robert M. Weetman; Robert L. Baehner


The Journal of Pediatrics | 1977

Possible breast milk transmission of group B streptococcal infection.

Richard L. Schreiner; Thomas D. Coates; Penelope G. Shackelford


Cancer | 1989

Integration of nutrition support into oncologic treatment protocols for high and low nutritional risk children with Wilms' tumor. A prospective randomized study

Karyl A. Rickard; Barbara Jaeger Godshall; Emily Loghmani; Thomas D. Coates; Jay L. Grosfeld; Robert M. Weetman; Catherine Detamore Lingard; Beth Bartlett Foland; Po-Lo Yu; Warren A. McGuire; Arthur J. Provisor; Tjien O. Oei; Robert L. Baehner


Cancer | 1989

Effectiveness of two methods of parenteral nutrition support in improving muscle mass of children with neuroblastoma or Wilms' Tumor. A randomized study

Karyl A. Rickard; Mary Corcoran Becker; Emily Loghmani; Jay L. Grosfeld; Barbara Jaeger Godshall; Robert M. Weetman; Thomas D. Coates; Catherine Detamore Lingard; Nancy Matchett White; Beth Bartlett Foland; P.L. Yu; Warren A. McGuire; Arthur J. Provisor; T-Jien O. Oei; Robert L. Baehner


Journal of Laboratory and Clinical Medicine | 1982

Correlation of in vitro and in vivo effects of gold compounds on leukocyte function: possible mechanisms of action

Wolach B; DeBoard Je; Thomas D. Coates; Robert L. Baehner; Laurence A. Boxer


Journal of Cell Biology | 1982

The effect of magnesium and 2-deoxyglucose (2-DOG) on chlorotetracycline (CTC) fluorescence in human polymorphonuclear neutrophils (PMN)

Thomas D. Coates; L. K. Han; L. A. Boxer; Robert L. Baehner

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