Thomas D. Greenwood

Aromatic heteroannulation via ortho lithiation-cyclization of N-acyl-2-bromobenzamides

Abstract N-acyl-2-bromobenzamides participate in metal-halogen exchange with n -BuLi to form N-acyl-2-lithiobenzamides, which undergo cyclization to afford 3-alkylidenephthalimidines.

Recent trends in the development of new anti-epileptic drugs

This article summarises reports of new compounds with anticonvulsant activity that have appeared in the patent literature over the past five years. The subject compounds are arranged and discussed according to the following two major categories: new candidate drugs with structural features in common with established anti-epileptic drugs (AEDs), and new candidate drugs with novel structures. The first category includes derivatives and analogues of carbamazepine and oxcarbazepine, felbamate, lamotrigine, phenytoin, tiagabine, topiramate and valproate. The second category describes compounds structurally unrelated to these AEDs, and includes acids and their derivatives, amides and vinylogous amides, aliphatic amines, benzimidazoles and imidazoles, benzodiazepines and benzothiazepines, benzopyrans, benzothiazoles, isoindolinones, lactams, lactones and thiolactones, 2(1H)-quinolones, quinoxalines and quinazolines, steroids and tricyclic steroid analogues, ureas and carbamates, and miscellaneous structural type...

N-Propargyl-substituted aromatic polyamides: preparation and thermal crosslinking

Abstract A series of high molecular weight aromatic polyamide copolymers derived from 4,4′-bis(methylamino)-diphenylmethane, 4,4′-bis(propargylamino)diphenylmethane and isophthaloyl dichloride was prepared as potential candidates for use as matrix resins in Kevlar(R) fibre composites. These polyamides, which contain pendant propargyl groups, underwent facile crosslinking at 280°C as evidenced by dramatic increases in their glass transition temperatures (Tg) and accompanying loss of solubility. Other attempts to effect crosslinking by exposure to ultraviolet light, electron beam or gamma radiation were unsuccessful.