Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Thomas D. O'Brien is active.

Publication


Featured researches published by Thomas D. O'Brien.


Clinical Biomechanics | 2014

Biomechanical demands differentiate transitioning vs. continuous stair ascent gait in older women

Lisa Alcock; Thomas D. O'Brien; Natalie Vanicek

BACKGROUND Stair ascent mechanics change with age, but little is known about the differing functional demands of transitioning and continuous ascent. Work investigating the risky transition from gait to ascent is sparse, and the strategies that older adults adopt to achieve these demanding tasks have not been investigated. METHODS This study compared the biomechanics of a 2-step transitional (floor-to-step2) and continuous ascent cycle (step1-to-step3) and investigated the role of limb preference in relation to dynamometer-derived knee strength during this transition. A biomechanical analysis of 36 women (60-83 years) ascending a 3-step staircase was conducted. FINDINGS The 2-step transitioning cycle was completed quicker, with a larger range of motion, increased forces, larger knee flexor and dorsiflexor moments and ankle powers (P≤0.05), but reduced hip and knee flexion, smaller hip extensor moments and hip and knee powers compared to continuous ascent. During the transition, 44% of the participants demonstrated a consistent limb preference. In these cases large between-limb extensor strength differences existed (13.8%) and 71% of these participants utilised the stronger limb to execute the 2-step transitional cycle. INTERPRETATION The preferential stronger-limb 2-step transitioning strategy conflicts with previous recommendations of a stronger lead limb for frail/asymmetric populations. Our findings suggest that most healthy older women with large between-limb differences utilise the stronger limb to achieve the considerable propulsion required to redirect momentum during the 2-step transition. The biomechanical demands of ascent, relative to limb strength, can inform exercise programmes by targeting specific muscle groups to help older adults maintain/improve general functioning.


Arthritis Care and Research | 2016

Can Creatine Supplementation Improve Body Composition and Objective Physical Function in Rheumatoid Arthritis Patients? A Randomized Controlled Trial

Thomas J. Wilkinson; Andrew B. Lemmey; Jeremy Jones; Fazal Sheikh; Yasmeen Ahmad; Sarang Chitale; Peter Maddison; Thomas D. O'Brien

Rheumatoid cachexia (muscle wasting) in rheumatoid arthritis (RA) patients contributes to substantial reductions in strength and impaired physical function. The objective of this randomized controlled trial was to investigate the effectiveness of oral creatine (Cr) supplementation in increasing lean mass and improving strength and physical function in RA patients.


Physiotherapy | 2015

Age-related changes in physical functioning: correlates between objective and self-reported outcomes

Lisa Alcock; Thomas D. O'Brien; Natalie Vanicek

OBJECTIVES To quantify the variance attributable to age and estimate annual decline in physical function and self-reported health using a battery of outcome measures in healthy older females. To determine whether self-reported functional losses are similar to those measured objectively and which best represent overall physical capacity. DESIGN Experimental study, cross-sectional analysis. SETTING Human Performance Laboratory, University setting. PARTICIPANTS Thirty-nine community-dwelling women (mean [SD] age=71.5 [7.3] years, range 60 to 83 years) completed a battery of objective measures of function and a self-reported health status survey. MAIN OUTCOME MEASURES Objective measures: gait speed; TUG test; sit-to-stand; concentric knee flexor and extensor moments; self-reported: the SF-36. RESULTS Using a cross-sectional approach, annual declines were estimated for: TUG time (2.1%); gait speed (1.2%); knee extensor (2.2%) and flexor moments (3.0%); and self-reported Physical Functioning (0.9 to 1.2%) (p≤0.001). Linear regression indicated that age explained moderate variance in the objective (R(2)=21 to 34%) and self-reported (R(2)=14 to 28%) outcomes. TUG time and gait speed was significantly correlated with all objective outcomes except sit-to-stand (r=0.46 to 0.83) and most of the self-reported (r=0.40 to 0.63) outcomes (p<0.01). CONCLUSIONS Age-related functional deterioration was estimated precisely across both objective and self-reported outcomes. Greater strength losses for the knee flexors compared to the extensors indicate an unequal strength loss of antagonistic muscle pairs which has implications for the safe completion of many functional tasks including obstacle negotiation, stair locomotion, postural transitions, and ultimately knee joint stability. Furthermore, walking speed and TUG time correlated most strongly with many of the outcomes highlighting their importance as global indicators of physical capacity.


Journal of Vascular Surgery | 2015

Dynamic muscle quality of the plantar flexors is impaired in claudicant patients with peripheral arterial disease and associated with poorer walking endurance

Stephanie King; Natalie Vanicek; Thomas D. O'Brien

OBJECTIVE Peripheral arterial disease and intermittent claudication (PAD-IC) negatively affects physical activity and function. There is evidence for plantarflexor muscle dysfunction and weakness; however, the extent to which this dysfunction can be attributed to reduced muscle size or quality, or both, is not yet known. This study investigated whether in vivo plantarflexor muscle quality during static and dynamic contractions is altered by PAD-IC and whether such changes are associated with impaired walking endurance according to initial and absolute claudication distances. METHODS The study recruited 22 participants, consisting of 10 healthy controls and 12 claudicant patients with occlusion of the superficial femoral artery (seven unilateral and five bilateral). Muscle quality of the combined gastrocnemius muscles during static contractions was calculated by normalizing the estimated maximal potential muscle force to the physiological cross-sectional area of the lateral and medial gastrocnemius. Muscle quality during dynamic contractions of the combined plantarflexor muscles was calculated as the ratio of peak voluntary concentric plantarflexor power and the summed volume of lateral and medial gastrocnemius. RESULTS Dynamic muscle quality was 24% lower in the claudicating-limb and asymptomatic-limb groups compared with controls (P = .017 and P = .023). The differences were most apparent at the highest contraction velocity (180°/s). Dynamic muscle quality was associated with reduced walking endurance (R = 0.689, P = .006 and R = 0.550, P = .042 for initial and absolute claudication distance, respectively). The claudicating-limb group demonstrated a trend toward reduced static muscle quality compared with controls (22%, P = .084). The relative contribution of the soleus muscle to plantarflexion maximum voluntary contraction was significantly higher in the claudicating-limb and asymptomatic-limb groups than in controls (P = .012 and P = .018). CONCLUSIONS The muscle strength of the plantarflexors in those with PAD-IC appears to be impaired at high contraction velocities. This may be explained by some reduction in gastrocnemii muscle quality and a greater reliance on the prominently type I-fibered soleus muscle. The reduced dynamic capability of the plantarflexor muscles was associated with disease severity and walking ability; therefore, efforts to improve plantarflexor power through dynamic exercise intervention are vital to maintain functional performance.


Journal of Biomechanics | 2017

Achilles tendon moment arm length is smaller in children with cerebral palsy than in typically developing children

Barbara M. Kalkman; Lynn Bar-On; Francesco Cenni; Constantinos N. Maganaris; Alfie Bass; Gill Holmes; Kaat Desloovere; Gabor Barton; Thomas D. O'Brien

When studying muscle and whole-body function in children with cerebral palsy (CP), knowledge about both internal and external moment arms is essential since they determine the mechanical advantage of a muscle over an external force. Here we asked if Achilles tendon moment arm (MAAT) length is different in children with CP and age-matched typically developing (TD) children, and if MAAT can be predicted from anthropometric measurements. Sixteen children with CP (age: 10y 7m±3y, 7 hemiplegia, 12 diplegia, GMFCS level: I (11) and II (8)) and twenty TD children (age: 10y 6m±3y) participated in this case-control study. MAAT was calculated at 20° plantarflexion by differentiating calcaneus displacement with respect to ankle angle. Seven anthropometric variables were measured and related to MAAT. We found normalized MAAT to be 15% (∼7mm) smaller in children with CP compared to TD children (p=0.003). MAAT could be predicted by all anthropometric measurements with tibia length explaining 79% and 72% of variance in children with CP and TD children, respectively. Our findings have important implications for clinical decision making since MAAT influences the mechanical advantage about the ankle, which contributes to movement function and is manipulated surgically.


Muscle & Nerve | 2016

Gastrocnemius muscle architecture and achilles tendon properties influence walking distance in claudicants with peripheral arterial disease.

Stephanie King; Natalie Vanicek; Thomas D. O'Brien

The extent to which gastrocnemius muscle and Achilles tendon properties contribute to the impaired walking endurance of claudicants is not known.


Journal of Electromyography and Kinesiology | 2016

Lower limb joint stiffness and muscle co-contraction adaptations to instability footwear during locomotion

Charlotte Apps; Thorsten Sterzing; Thomas D. O'Brien; Mark Lake

Unstable shoes (US) continually perturb gait which can train the lower limb musculature, but muscle co-contraction and potential joint stiffness strategies are not well understood. A shoe with a randomly perturbing midsole (IM) may enhance these adaptations. This study compares ankle and knee joint stiffness, and ankle muscle co-contraction during walking and running in US, IM and a control shoe in 18 healthy females. Ground reaction forces, three-dimensional kinematics and electromyography of the gastrocnemius medialis and tibialis anterior were recorded. Stiffness was calculated during loading and propulsion, derived from the sagittal joint angle-moment curves. Ankle co-contraction was analysed during pre-activation and stiffness phases. Ankle stiffness reduced and knee stiffness increased during loading in IM and US whilst walking (ankle, knee: p=0.008, 0.005) and running (p<0.001; p=0.002). During propulsion, the opposite joint stiffness re-organisation was found in IM whilst walking (both joints p<0.001). Ankle co-contraction increased in IM during pre-activation (walking: p=0.001; running: p<0.001), and loading whilst walking (p=0.003), not relating to ankle stiffness. Results identified relative levels of joint stiffness change in unstable shoes, providing new evidence of how stability is maintained at the joint level.


BMJ open sport and exercise medicine | 2016

Systematic review of physical activity and exercise interventions to improve health, fitness and well-being of children and young people who use wheelchairs

Thomas D. O'Brien; Jane Noyes; Llinos Haf Spencer; Hans-Peter Kubis; Richard P. Hastings; Rhiannon Whitaker

Aim To perform a systematic review establishing the current evidence base for physical activity and exercise interventions that promote health, fitness and well-being, rather than specific functional improvements, for children who use wheelchairs. Design A systematic review using a mixed methods design. Data sources A wide range of databases, including Web of Science, PubMed, BMJ Best Practice, NHS EED, CINAHL, AMED, NICAN, PsychINFO, were searched for quantitative, qualitative and health economics evidence. Eligibility participants: children/young people aged >25 years who use a wheelchair, or parents and therapists/carers. Intervention: home-based or community-based physical activity to improve health, fitness and well-being. Results Thirty quantitative studies that measured indicators of health, fitness and well-being and one qualitative study were included. Studies were very heterogeneous preventing a meta-analysis, and the risk of bias was generally high. Most studies focused on children with cerebral palsy and used an outcome measure of walking or standing, indicating that they were generally designed for children with already good motor function and mobility. Improvements in health, fitness and well-being were found across the range of outcome types. There were no reports of negative changes. No economics evidence was found. Conclusions It was found that children who use wheelchairs can participate in physical activity interventions safely. The paucity of robust studies evaluating interventions to improve health and fitness is concerning. This hinders adequate policymaking and guidance for practitioners, and requires urgent attention. However, the evidence that does exist suggests that children who use wheelchairs are able to experience the positive benefits associated with appropriately designed exercise. Trial registration number CRD42013003939.


Footwear Science | 2017

Biomechanical locomotion adaptations on uneven surfaces can be simulated with a randomly deforming shoe midsole

Charlotte Apps; Thorsten Sterzing; Thomas D. O'Brien; Rui Ding; Mark Lake

A shoe with unsystematic perturbations, similar to natural uneven terrain, may offer an enhanced training stimulus over current unstable footwear technologies. This study compared the instability of a shoe with unpredictably random midsole deformations, an irregular surface and a control shoe-surface while treadmill walking and running. Three-dimensional kinematics and electromyography were recorded of the lower limb in 18 active males. Gait cycle characteristics, joint angles at initial ground contact and maximum values during stance, and muscle activations prior to initial contact and during loading were analysed. Perceived stability, injury-risk and energy consumption were evaluated. Instability was assessed by movement variability, muscular activations and subjective ratings. Posture alterations at initial contact revealed active adaptations in the irregular midsole and irregular surface to maintain stability while walking and running. Variability of the gait cycle and lower limb kinematics increased on the irregular surface compared to the control across locomotion types. Similarly increased variability (coefficient of variation) were found in the irregular midsole compared to the control for frontal ankle motion (walk: 31.1 and 14.9, run: 28.1 and 11.6), maximum sagittal knee angle (walk: 7.6 and 4.8, run: 2.8 and 2.4), and global gait characteristics during walking only (2.1 ± 0.5 and 1.6 ± 0.3). Tibialis anterior pre-activation reduced and gastrocnemius activation increased in the irregular midsole compared to the control across locomotion types. During running, peroneus longus activation increased in the irregular midsole and irregular surface. Results indicate random shoe midsole deformations enhanced instability relative to the control and simulated certain locomotion adaptations of the irregular surface, although less pronounced. Thus, a shoe with unpredictable instability revealed potential as a novel instability-training device.


Experimental Physiology | 2017

Medial gastrocnemius muscle stiffness cannot explain the increased ankle joint range of motion following passive stretching in children with cerebral palsy

Barbara M. Kalkman; Lynn Bar-On; Francesco Cenni; Constantinos N. Maganaris; Alfie Bass; Gill Holmes; Kaat Desloovere; Gabor Barton; Thomas D. O'Brien

What is the central question of this study? Can the increased range of motion seen acutely after stretching in children with cerebral palsy be explained by changes in the stiffness of the medial gastrocnemius fascicles? What is the main finding and its importance? We show, for the first time, that passive muscle and tendon properties are not changed acutely after a single bout of stretching in children with cerebral palsy and, therefore, do not contribute to the increase in range of motion. This contradicts common belief and what happens in healthy adults.

Collaboration


Dive into the Thomas D. O'Brien's collaboration.

Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Barbara M. Kalkman

Liverpool John Moores University

View shared research outputs
Top Co-Authors

Avatar

Constantinos N. Maganaris

Liverpool John Moores University

View shared research outputs
Top Co-Authors

Avatar

Francesco Cenni

Katholieke Universiteit Leuven

View shared research outputs
Top Co-Authors

Avatar

Lynn Bar-On

Katholieke Universiteit Leuven

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Kaat Desloovere

American Physical Therapy Association

View shared research outputs
Researchain Logo
Decentralizing Knowledge