Thomas E. Eble

Lincomcyin Related Antibiotics

Publisher Summary This chapter describes Lincomcyin related antibiotics, focusing on their production, therapeutic use and pharmacology, as well as their extraction, separation, and purification. The lincomycin hydro chloride described by Herr and Bergy was a hemihydrate and consisted of light, fluffy, needle-like crystals. A second form of crystals, isolated by VanOverloop, existed as small, dense cubes. Lincomycin has found usage in a variety of disease states as an antibacterial agent active against susceptible strains of streptococci, pneumococci, and staphylococci. When 1-demethylthio-l-ethylthio-l’-dernethyllincomycin is treated with hydrazine, a reaction takes place similar to that with lincomycin. The hydrazide of PHA is formed and the sugar portion ethyl thiolincosaminide (ETL) is obtained. The crystalline VI hydrochloride and a small amount of impurity was separated by filtration (420 mg). An additional 200 mg of VI hydro chloride and a small amount of impurity was obtained from the filtrate. These preparations were combined and dissolved in 18 ml of water.