Thomas Glück

Antimicrobial Resistance in

Intubated patients often become colonized and subsequently infected by Pseudomonas aeruginosa. The pathogen is difficult to eradicate because it

Long-Term Prognosis of

Researchers examining outcomes among patients with Staphylococcus aureus bacteremia have usually focused on 30-day or in-hospital mortality. But how do

Antimicrobial Use and Resistance in Europe

Antimicrobial resistance in Streptococcus pneumoniae, seen since the late 1970s, is a major public health problem worldwide. Both resistance and

What Is the True Incidence of Severe Sepsis in the U.S.

In 1992, the American College of Chest Physicians and the Society for Critical Care Medicine issued definitions of sepsis, severe sepsis, and septic

Efficacy of Human Monoclonal Antibodies Against H5N1 Influenza

Although currently circulating H5N1 viruses are not efficiently transmitted from person to person, H5N1 influenza remains a major global threat. New treatment strategies are urgently needed. Now, researchers (one of whom is named on a patent relating to the generation and use of human monoclonal antibodies) have generated anti-H5N1 monoclonal antibodies (mAbs) from B-cells of four Vietnamese patients who survived H5N1 infections. They selected …

Is There a Difference Between Culture-Positive and Culture-Negative Septic Shock?

Severe sepsis and septic shock are among the leading causes of death for patients requiring intensive care. In roughly one third of cases the

Pyelonephritis in Older Patients? Look for Urogenital Cancer

Pyelonephritis occurs more frequently among older individuals and is commonly associated with obstruction in the urinary tract. Some epidemiological

Do Pneumococcal and Respiratory Virus Infections Trigger Cardiovascular Morbidity

Previous reports indicated an increased incidence of myocardial infarction (MI) following influenza infection (e.g., NEJM JW Infect Dis Mar 2018 and N

Corticosteroids Are Not Beneficial for

Pneumocystis jirovecii pneumonia (PcP) is a life-threatening pulmonary infection that can affect severely immunocompromised patients. Historically, PcP

De-escalation and Discontinuation of Antibiotics for Febrile Neutropenia?

Guidelines on antibiotic stewardship in hematology have been published by the Infectious Diseases Society of America (IDSA; Clin Inf Dis 2011; 52:427)