Thomas Himmler

Synthesis and antibacterial in vitro activity of novel analogues of nematophin

The synthesis and in vitro antibacterial activity of new derivatives and analogues of nematophin are described. It was shown that the unsubstituted amide NH-group is essential for bioactivity. Alkyl- or arylsubstitution at the 1-position results in a distinct increase of antibacterial activity. Addition of protein (blood or serum) to the culture media reduces the inhibitory activity on bacteria.

Katalytische Reduktion von aromatischen Carbonsäurefluoriden zu Aldehyden

Abstract Aromatic acyl fluorides can be reduced to the corresponding aldehydes in the presence of palladium complexes. Polymethylhydrosiloxane (PMHS) gives better results than hydrogen.