Thomas J. Deeley

The necropsy findings in carcinoma of the bronchus

Abstract This article describes the findings in 680 necropsy cases of carcinoma of the bronchus. The incidence of metastases at different sites is related to the histological type of the primary tumour.

Intra-alveolar Carcinoma of the Jaw. Treatment by Supervoltage Radiotherapy

This article describes the possible sites of origin, the clinical and radiological features and the treatment of intra-alveolar carcinoma of the jaw. Nine patients have been treated with supervoltage radiotherapy and the response of the tumour to this treatment is given.

The Treatment of Carcinoma of the Bladder by Supervoltage X Rays

Four hundred and twelve cases of cancer of the bladder treated by supervoltage radiotherapy have been analysed. The treatment policy is discussed in relation to the extent of the tumour, its histological pattern and the probability of its spread in the bladder wall and to the pelvic lymphatic nodes. The techniques of treatment are described. The survival rates are given for the stage of the disease, the histological type, the site of the tumour in the bladder and its cystoscopic appearance. Lesions with extravesical spread to both sides of the pelvis were found to have a worse prognosis than those with a spread to one side. The reactions after treatment and the late complications are described and their incidence related to the tumour dose. The tumour response at different times after treatment has been analysed for the different histological types and the site of the lesion. The results of a small prospective investigation suggest that the disappearance rate does not increase with a higher tumour dose. P...

A clinical trial to compare two different tumour dose levels in the treatment of advanced carcinoma of the bronchus

The author describes a clinical trial designed to compare the effects of two different dose levels for advanced inoperable anaplastic carcinoma of the bronchus. The results in 102 patients suggest that a calculated tumour dose of 3000 rads gives a better survival rate and less morbidity than does a tumour dose of 4000 rads.

The Treatment of Carcinoma of the Bronchus Review article

“We have before us a wide and almost appalling sphere for our exertions, humbling us by the present aspect of the extent to which this disease is rife. Instead of decreasing as a result of advancing science death by cancer has increased alarmingly.” These words are as apposite to-day as they were when Dr. William Marsden made his report at the end of the first years work at the Free Cancer Hospital which he had founded in 1851. Since this time our understanding of malignant disease has been greatly enhanced by observation and investigation, but the control of cancer is still only a hope for the future. There is a steady annual increase in the number of patients dying from the disease and this increase is most marked in the case of lung cancer. Until this disease can be controlled, either through prophylactic measures or by improved chemotherapeutic agents, or by some method as yet undiscovered, treatment will continue to be either by the surgical removal of involved structures or by the ablation of malig...

The effects of radiation on the lungs in the treatment of carcinoma of the bronchus

Summary A description is given of the radiological, physiological and pathological changes occurring in the lungs of sixty-one patients treated for carcinoma of the bronchus by megavoltage x-ray therapy. The changes in the lung are similar to the changes caused by radiation in other tissues, there is a stage of reaction to the treatment followed by fibrosis and repair of damage. Radiological evidence of lung shrinkage was found in all patients who survived for fifteen months. As a result of this shrinkage there is a reduction in the physiological function of the lungs. The fibrosed lung is prone to infection and the need for immediate antibiotic therapy is stressed. The incidence and development of lung shrinkage was similar for patients treated by 8 MeV x-rays and 240 kV x-rays when a radical tumour dose was given.

Radiotherapy in the treatment of carcinoma of the penis

Abstract Carcinoma of the penis is a rare disease; this article reviews the clinical picture and results of radiotherapy in 33 patients. The irradiation treatment of early lesions compares favourably with the surgical results.

Solitary metastases in Carcinoma of the bronchus

Summary The necropsy reports of 647 patients with a proved carcinoma of the bronchus have been received to determine the incidence of solitary secondary deposits. It is shown that these are more likely to be found with squamous lesions of the other histological types. The fact that some deposits may be solitary calls for a more active approach to the treatment of these lesions, and doses of radiotherapy should be given at ablating the solitary metastasis rather than alleviating troublesome symptoms.

Drill biopsy: a technique using a high-speed drill.

DRILL biopsy has become accepted, particularly in radiotherapy departments, as a quick and ready method of obtaining tumour tissue for microscopical examination. Admittedly, the procedure has certain limitations and sections made from the small sample may not always be representative of the whole tumour. This is a difficulty inherent in the method which may make the pathologist hesitate to give a firm diagnosis, especially if the appearance of the section suggests a tumour with