Thomas J. Hosted
Schering-Plough
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Publication
Featured researches published by Thomas J. Hosted.
Journal of Industrial Microbiology & Biotechnology | 2001
Thomas J. Hosted; Tim X. Wang; D C Alexander; Ann C. Horan
Evernimicin (EV) belongs to the orthosomycin class of antibiotics and consists of several modified L- and D-deoxysugars containing unusual orthoester and glycosyl linkages and two orsellinic acid groups, one that is halogenated. The EV biosynthetic gene cluster from Micromonospora carbonacea var. africana ATCC39149 was localized by hybridization to a dTDP-D-glucose 4,6-dehydratase probe and a 120-kb region containing the EV biosynthetic cluster and surrounding regions has been sequenced. BLAST analysis has identified a type I polyketide synthase for orsellinic acid biosynthesis as well as enzymes required for L- and D-deoxyglucose and D-deoxymannose synthesis. In addition, genes involved in glycosyltransfer and resistance were identified. Insertional mutations in several biosynthetic genes blocked EV production, indicating a role for these genes in EV biosynthesis. Journal of Industrial Microbiology & Biotechnology (2001) 27, 386–392.
The Journal of Antibiotics | 2004
Jamie Unwin; Scott Standage; Dylan C. Alexander; Thomas J. Hosted; Ann C. Horan; Elizabeth M. H. Wellington
Microbiology | 2003
Dylan C. Alexander; David J. Devlin; Duane D. Hewitt; Ann C. Horan; Thomas J. Hosted
Archive | 2001
Thomas J. Hosted; Tim X. Wang; Ann C. Horan
Microbiology | 2004
Thomas J. Hosted; Tim X. Wang; Ann C. Horan
Archive | 2001
Thomas J. Hosted; Ann C. Horan
Archive | 2005
Thomas J. Hosted; Scott S. Walker; Marvin Bayne
Archive | 2001
Thomas J. Hosted; Ann C. Horan
Circulation | 2006
Joyce J. Hwa; Lu Yang; Melanie Henry; Glen Tetzloff; Lizbeth Hoos; John Cook; Li-ji Zhu; Margaret van Heek; Nicholas J. Murgolo; Thomas J. Hosted; Diane Levitan; Marsha Smith; Scott W. Altmann; Harry R. Davis
international symposium on microarchitecture | 2004
Thomas J. Hosted; Timothy Wang; Ann C. Horan