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Dive into the research topics where Thomas J. Hosted is active.

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Featured researches published by Thomas J. Hosted.


Journal of Industrial Microbiology & Biotechnology | 2001

Characterization of the biosynthetic gene cluster for the oligosaccharide antibiotic, Evernimicin, in Micromonospora carbonacea var. africana ATCC39149.

Thomas J. Hosted; Tim X. Wang; D C Alexander; Ann C. Horan

Evernimicin (EV) belongs to the orthosomycin class of antibiotics and consists of several modified L- and D-deoxysugars containing unusual orthoester and glycosyl linkages and two orsellinic acid groups, one that is halogenated. The EV biosynthetic gene cluster from Micromonospora carbonacea var. africana ATCC39149 was localized by hybridization to a dTDP-D-glucose 4,6-dehydratase probe and a 120-kb region containing the EV biosynthetic cluster and surrounding regions has been sequenced. BLAST analysis has identified a type I polyketide synthase for orsellinic acid biosynthesis as well as enzymes required for L- and D-deoxyglucose and D-deoxymannose synthesis. In addition, genes involved in glycosyltransfer and resistance were identified. Insertional mutations in several biosynthetic genes blocked EV production, indicating a role for these genes in EV biosynthesis. Journal of Industrial Microbiology & Biotechnology (2001) 27, 386–392.


The Journal of Antibiotics | 2004

Gene cluster in Micromonospora echinospora ATCC15835 for the biosynthesis of the gentamicin C complex

Jamie Unwin; Scott Standage; Dylan C. Alexander; Thomas J. Hosted; Ann C. Horan; Elizabeth M. H. Wellington


Microbiology | 2003

Development of the Micromonospora carbonacea var. africana ATCC 39149 bacteriophage pMLP1 integrase for site-specific integration in Micromonospora spp.

Dylan C. Alexander; David J. Devlin; Duane D. Hewitt; Ann C. Horan; Thomas J. Hosted


Archive | 2001

Everninomicin biosynthetic genes

Thomas J. Hosted; Tim X. Wang; Ann C. Horan


Microbiology | 2004

Characterization of the Streptomyces lavendulae IMRU 3455 linear plasmid pSLV45.

Thomas J. Hosted; Tim X. Wang; Ann C. Horan


Archive | 2001

Isolated nucleic acids from micromonospora rosaria plasmid pMR2 and vectors made therefrom

Thomas J. Hosted; Ann C. Horan


Archive | 2005

Reporter assay screens for protein targets in Saccharomyces cerevisiae

Thomas J. Hosted; Scott S. Walker; Marvin Bayne


Archive | 2001

Isolation of micromonospora carbonacea var africana pMLP1 integrase and use of integrating function for site-specific integration into micromonospora halophitica and micromonospora carbonacea chromosome

Thomas J. Hosted; Ann C. Horan


Circulation | 2006

Abstract 1586: Ezetimibe Reduces Hepatic Steatosis in Diet-Induced Obese Mice

Joyce J. Hwa; Lu Yang; Melanie Henry; Glen Tetzloff; Lizbeth Hoos; John Cook; Li-ji Zhu; Margaret van Heek; Nicholas J. Murgolo; Thomas J. Hosted; Diane Levitan; Marsha Smith; Scott W. Altmann; Harry R. Davis


international symposium on microarchitecture | 2004

Characterization of the Streptomyces lavendulae IMRU 3455 linear plasmid pSLV45

Thomas J. Hosted; Timothy Wang; Ann C. Horan

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