Thomas J. Richard

Emulsions of paramagnetic contrast agents for magnetic resonance imaging (MRI).

Emulsions of paramagnetic contrast agents, and processes of making and using them are disclosed. The emulsions contain water, a dispersed oil phase and a complex of a paramagnetic metal ion and an organic chelator having a C10 -C30 unsaturated aliphatic group. The emulsions are very stable and therapeutically acceptable for intravenous administration to enhance MRI.

A perfluorochemical emulsion for prehospital resuscitation of experimental hemorrhagic shock : a prospective, randomized, controlled study

Objective: To evaluate the efficacy of a novel, oxygen-transporting perfluorochemical emulsion as a prehospital therapy, using a canine hemorrhagic shock model based on compromised tissue oxygenation. Design: Prospective, randomized, controlled study. Setting: HemaGen animal laboratory. Subjects: Sixteen healthy, adult male grade beagles (weight 8 to 14 kg). Interventions: Administration of lactated Ringers solution (n=8), 15 mL/kg and perfluo rochemical emulsion admixed with physiologic salts (n=8), 15 mL/kg Measurements and Main Results: Pao 2 increased significantly (p<.01) in the perfluorochemical-treated animals for 2 hrs afterresuscitation

Paramagnetic complexes of n-alkyl-n-hydroxylamides of organic acids and emulsions containing same for magnetic resonance imaging (mri)

Emulsions of paramagnetic contrast agents, and processes of making and using them are disclosed. The emulsions contain water, a dispersed oil phase and a complex of a paramagnetic metal ion and an organic acid chelator, for example DTPA (diethylenetriaminepentaacetic acid), having a C10 -C30 saturated aliphatic group and an hydroxyl group bonded to the nitrogen atom. The emulsions are very stable and therapeutically acceptable for intravenous administration to enhance MRI imaging.

Biological imaging emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use

Oil and water emulsions containing alkylphosphoryl choline or alkylglycerophosphoryl choline surfactants are disclosed. The surfactants have the following general structures: ##STR1## In the above general structures, R1, R2 or R3 is alkyl, alkenyl, fluoroalkyl and alkenyl; and PC is the phosphoryl choline. The emulsions are useful as oxygen transport agents, artificial bloods or red blood cell substitutes. The emulsions are also useful as contrast agents for biological imaging by the modalities of nuclear magnetic resonance, x-ray and ultra sound.

A Perfluorochemical Emulsion for Prehospital Resuscitation of Experimental Hemorrhagic Shock: A Prospective, Randomized, Controlled Study

ObjectiveTo evaluate the efficacy of a novel, oxygen-transporting perfluorochemical emulsion as a prehospital therapy, using a canine hemorrhagic shock model based on compromised tissue oxygenation. DesignProspective, randomized, controlled study. SettingHemaGen animal laboratory. SubjectsSixteen healthy, adult male grade beagles (weight 8 to 14 kg). InterventionsAdministration of lactated Ringers solution (n = 8), 15 mL/kg and perfluorochemical emulsion admixed with physiologic salts (n = 8), 15 mL/kg Measurements and Main ResultsPao2 increased significantly (p < .01) in the per-fluorochemical-treated animals for 2 hrs after resuscitation. Mixed venous Po2 returned to preshock values in the perfluorochemical-treat-ed dogs for 60 mins after fluid administration (p < .01). Normalization of hemodynamic variables was not observed in either group. Although not statistically significant, survival of the lactated Ringers solution-treated animals was 63% compared with 100% for the perfluorochemical-treated dogs at 3 hrs after resuscitation. ConclusionsResuscitation with a perfluorochemical emulsion augmented oxygen transport and restored global tissue oxygenation after massive hemorrhage, which translated into improved survival when compared with the group receiving an equal volume of lactated Ringers solution. (Crit Care Med 1994; 22:680–689)