Thomas Little
University of Washington
Bioorganic & Medicinal Chemistry Letters | 1998
Cyprian O. Ogbu; Maher Qabar; P. Douglas Boatman; Jan Urban; Joseph Patrick Meara; Mark D. Ferguson; John Tulinsky; Chris Lum; Suresh Babu; Mark A. T. Blaskovich; Hiroshi Nakanishi; Fuqiang Ruan; Bolong Cao; Ryan Minarik; Thomas Little; Sherry Nelson; Minh T. Nguyen; Anna Gall; Michael Kann
The general approach of using a bicyclic template to produce inhibitors of the protease superfamily of enzymes has been investigated. The Diels-Alder cycloaddition reaction on solid support has been found to be highly efficient for the synthesis of libraries of compounds that mimic the β-strand secondary structure of proteins. Several potent and selective inhibitors of proteases have been discovered.
Synthetic Communications | 2002
Thomas Little; Joseph Patrick Meara; Fuqiang Ruan; Minh T. Nguyen; Maher Qabar
ABSTRACT The efficient synthesis of several new and novel 4-substituted triazolidindiones (urazoles) starting from isocyanates, amines, anilines and carboxylic acids is reported.
Bioorganic & Medicinal Chemistry Letters | 2003
Marcin Stasiak; Christopher Mehlin; Erica Boni; Tomas Vaisar; Thomas Little; Hwa Ok Kim; Maher Qabar
The discovery of a sulphonamide by-product with VLA-4 antagonistic activity led to a series of potent, small molecule VLA-4 antagonists. Synthesis, SAR and in vivo evaluation of the selected compound will be presented.
Archive | 2011
Neil S. Cutshall; Jennifer Lynn Gage; Thomas Neil Wheeler; Thomas Little
Archive | 2008
Ian L. Scott; Vladimir Kuksa; Mark W. Orme; Feng Hong; Thomas Little; Ryo Kubota
Archive | 2005
Mark A. T. Blaskovich; Ted Baughman; Thomas Little; William Patt; Maher Qabar; Lauri Schultz; Feng Hong; Gangadhar Nagula; Jennifer Gage; James Jeffrey Howbert
Archive | 2011
Ian L. Scott; Vladimir Kuksa; Mark W. Orme; Thomas Little; Anna Gall; Feng Hong
Archive | 2008
Ian L. Scott; Vladimir Kuksa; Mark W. Orme; Thomas Little; Anna Gall; Jennifer Gage; Feng Hong
Archive | 2008
Ian L. Scott; Vladimir Aleksandrovich Kuska; Anna Gall; Mark W. Orme; Jennifer Gage; Thomas Little; Qin Jiang; Lana Michele Rossiter; Kevin F Mcgee; Ryo Kubota
Archive | 2015
Neil S. Cutshall; Jennifer Lynn Gage; Thomas Little; Wayne Douglas Luke; Elisabeth C.A. Brot; Marco Jonas; Michael James Mcdermott; Karl Reineke
