Thomas M. Pisansky

The radial distance of extraprostatic extension of prostate carcinoma : Implications for prostate brachytherapy

Extraprostatic extension (EPE) is an unfavorable prognostic factor in patients with prostate carcinoma. Prior studies have reported the linear extent of EPE measured circumferentially along the edge of the prostate. In this study, the authors defined and evaluated a novel measure of EPE in a large series of radical prostatectomy specimens. These results have important clinical implications in the management of localized prostate carcinoma by brachytherapy and other modalities.

A multiple prognostic index predictive of disease outcome after irradiation for clinically localized prostate carcinoma.

This investigation was conducted to identify independent pretherapy disease‐related factors associated with disease outcome in patients with clinically localized carcinoma of the prostate (CaP) and to develop models that incorporated relevant covariates for estimating the risk of disease relapse after irradiation (RT).

Workgroup 5: Assessment of prostate carcinoma in core needle biopsy - Definition of minimal criteria for the diagnosis of cancer in biopsy material

Fundacion Puigvert (IVNA), Barcelona, Spain. Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland. Pathology Department, Northwest Hospital, Seattle, Washington. Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota. Department of Pathology, Mayo Clinic, Rochester, Minnesota. Department of Pathology, Mercy Hospital Medical Center, Des Moines, Iowa. UroCor Inc., Oklahoma City, Oklahoma. * Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota. Clinica Plato-Fundacio Privada, Barcelona, Spain.

Patterns of tumor relapse following mastectomy and adjuvant systemic therapy in patients with axillary lymph node‐positive breast cancer. Impact of clinical, histopathologic, and flow cytometric factors

Background. This analysis was conducted to evaluate the impact of selected clinical, histopathologic, and flow cytometric factors on sites of initial tumor relapse after postmastectomy adjuvant systemic therapy.

Predictors of survival for prostate carcinoma patients treated with salvage radical prostatectomy after radiation therapy

Salvage radical prostatectomy is a treatment option for patients with recurrent cancer following radiation therapy. This study was conducted to identify predictors of survival for patients treated with salvage radical prostatectomy.

An enhanced prognostic system for clinically localized carcinoma of the prostate

This investigation was conducted to develop an enhanced prognostic system based on readily available and independently predictive tumor‐related factors for patients with clinically localized prostate carcinoma.

The evaluation and treatment of patients receiving radiation therapy for carcinoma of the esophagus: Results of the 1992-1994 Patterns of Care Study

For the first time, a Patterns of Care Study (PCS) was conducted in 1992–1994 to determine the national practice standards in evaluating and treating patients with esophageal carcinoma and to determine the degree to which clinical trials have been incorporated into national practice.

p53 Protein overexpression is associated with increased cell proliferation in patients with locally recurrent prostate carcinoma after radiation therapy

The biologic changes in recurrent prostate carcinoma following radiation therapy are not fully understood. The authors sought to determine the level of p53 protein overexpression and its association with cellular proliferation (Ki‐67 labeling index), glutathione S‐transferase‐π (GST‐π) expression, and other clinical pathologic findings in patients with locally persistent prostate carcinoma after radiation therapy.

The relevance of prostatectomy findings for brachytherapy selection in patients with localized prostate carcinoma.

The efficacy of brachytherapy for patients with localized prostate carcinoma depends on adequate radiotherapeutic coverage of the primary tumor and its subclinical extraprostatic extensions. Predictive models based on pretherapy factors may be useful to estimate the likelihood for clinically relevant extraprostatic disease and may be incorporated into selection criteria for this procedure.

A pilot evaluation of alternating preoperative chemotherapy in the management of patients with locoregionally advanced breast carcinoma

This prospective trialiu was conducted to evaluate the outcome of patients treated with preoperative and postoperative chemotherapy, mastectomy, and irradiation for locoregionally advanced breast carcinoma.