Thomas Nicola
Boehringer Ingelheim
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Publication
Featured researches published by Thomas Nicola.
Organic Letters | 2010
Xiao-Jun Wang; Yibo Xu; Li Zhang; Dhileepkumar Krishnamurthy; Thomas Wirth; Thomas Nicola; Chris H. Senanayake
A three-stage process for the synthesis of LFA-1 inhibitor 1 from amine 4 with an overall yield of 65% is described. The key stage involves a Ph(3)PCl(2)-induced dehydration/cyclization of urea 6 followed by a regioselective bromination to give 1H-imidazo[1,2-a]imidazol-2-one 9. Br/Mg exchange of 9 followed by addition to SO(2) in THF and subsequent oxidation produces a sulfonyl chloride which is directly reacted with L-alaninamide using K(2)CO(3) as base in aqueous DMF/THF to give 1 in a one-pot operation. The process was implemented for the production of 1 on a metric ton scale.
Journal of Organic Chemistry | 2006
Nathan K. Yee; Vittorio Farina; Ioannis N. Houpis; Nizar Haddad; Rogelio P. Frutos; Fabrice Gallou; Xiao-Jun Wang; Xudong Wei; Robert D. Simpson; XuWu Feng; Victor Fuchs; Yibo Xu; Jonathan Tan; Li Zhang; Jinghua Xu; Lana L. Smith-Keenan; Jana Vitous; Michael D. Ridges; and Earl M. Spinelli; Michael E. Johnson; Kai Donsbach; Thomas Nicola; Michael Brenner; Eric Winter; and Paul Kreye; Wendelin Samstag
Organic Process Research & Development | 2005
Thomas Nicola; Michael Brenner; and Kai Donsbach; Paul Kreye
Archive | 2005
Waldemar Pfrengle; Thorsten Pachur; Thomas Nicola; Adil Duran
Archive | 2009
Waldemar Pfrengle; Thorsten Pachur; Thomas Nicola; Adil Duran
Archive | 2005
Thomas Herweck; Albrecht Jacobi; Thomas Nicola; Michael Wiese
Archive | 2005
Waldemar Pfrengle; Thorsten Pachur; Thomas Nicola; Adil Duran
Archive | 2005
Michael Brenner; Kai Donsbach; Thomas Nicola; Thomas Wirth
Archive | 2005
Thomas Herweck; Albrecht Jacobi; Thomas Nicola; Michael Wiese
Archive | 2005
Michael Brenner; Kai Donsbach; Thomas Nicola; Thomas Wirth
