Thomas Normanton Guim

Intoxicação aguda e abortos em cobaias pelas favas de Enterolobium contortisiliquum (Leg. Mimosoideae)

The objective was to study the acute toxicity and the abortive properties of Enterolobium contortisiliquum pods in guinea pigs. Pods of E. contortisiliquum were administered orally to 4 groups of 3 guinea pigs each. Another group of 3 guinea-pigs was used as control. Group 1 and 2 were fed with one dose of 5 and 10g of pods for kg body weight, respectively. The guinea pigs of Group 3 and 4 received 10 and 15g/kg, respectively, divided into daily doses of 5g/kg. One guinea pig from Group 2 and one from Group 4 died 12 and 18 hours after the end of the administration. Gross lesions were hemorrhages of the stomach and of the large and small gut, enlarged liver, and dilated gall bladder. Histologically, the liver had severe vacuolation and necrosis of periportal hepatocytes. In another experiment a ration containing 4% of pods of E. contortisiliquum was fed to 2 groups of 4 guinea-pigs, 35 days after mating. Four of the 8 guinea pigs aborted 6-15 days after the beginning of ingestion. The other 4 guinea pigs were not pregnant. All guinea pigs were euthanized after abortion or at the end of the experiment. Histologically all animals had mild to severe periportal hemorrhagic necrosis. All fetuses had variable degree of autolysis. In 4 fetuses studied no significant histologic lesions were observed. The acute lesions observed in guinea-pigs are similar than those observed in the spontaneous poisoning by Enterolobium spp. in cattle. Similar lesions are observed in guinea-pigs poisoned experimentally with saponins from E. gummiferum. The results of the experiments in pregnant guinea pigs suggest that E. contortisiliquum can be used to study the abortive effect of its pods or its toxic compounds.

Disease progression of dermatophytic pseudomycetoma in a Persian cat

BACKGROUND Dermatophytic pseudomycetoma is a subcutaneous fungal infection by Microsporum canis. AIMS This work describes a case of dermatophytic pseudomycetoma in a Persian cat. PATIENT AND METHODS A 3-year old female Persian cat showing alopecia, scaling and ulcerated nodules throughout the body, with presence of ulcerated nodules with yellow granular discharges on the dorsum, close to the tail. Mycological and histopathological examinations were realized. RESULTS Diagnosis of dermatophytic pseudomycetoma was established. The cat was treated with griseofulvin, and surgical excision was carried out. Response to therapy was effective during the first months, during which a reduction in nodule frequency was observed. However, despite maintaining the therapy levels, the lesions relapsed and progressed to the point of causing the animals death. CONCLUSION The clinic evolution showed the progressive and recurrent character of dermatophytic pseudomycetoma.

Ações de Prevenção do Câncer em Pequenos Animais pelo Serviço de Oncologia Veterinária da Universidade Federal de Pelotas (SOVET- UFPel)

The aim of this work is to report the actions carried out by SOVET-UFPel to raise the awareness of the population about animal cancer. The initiative came from the need to alert people about the prevention, diagnosis and treatment of cancer in animals.The Veterinary Oncology Service of the Federal University of Pelotas (SOVET-UFPel), together with other institutions in the country, initially built the National Campaign against Breast Cancer in Animals. Therefore, since the year 2014, a final event has been held in the month of October or beginning of November. This action was based on the October Rose campaign of humans.In this action, basic concepts of prevention, diagnosis and treatment of cancer in small animals in a playful and interactive way. The invitation to the events that took place was done through pre-screening by the students of the veterinary medicine course, who were previously trained to approach the population, as well as insertions in printed newspapers, television and social networks, conducted by the coordinators of the group. Starting in 2016, the campaign was expanded to raise awareness about skin cancer and the male genital tract, and was conducted in November using the Blue November campaign for humans.During these years, ludic lectures were given in schools for the initial grades and nine technical lectures for veterinary students. SOVET-UFPel also participated in events promoted by different groups, such as pet shops/veterinary clinics, in different parts of the city. The activities carried out by SOVET made the population aware, since the demand for the cancer services provided by the group in the area of clinical and pathological diagnosis increased by 68.85% over the four years.