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Dive into the research topics where Thomas R. Beattie is active.

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Featured researches published by Thomas R. Beattie.


Tetrahedron Letters | 1982

Synthesis of fluorodeoxyscylloinositol and phosphatidylfluorodeoxyscylloinositol

Shu Shu Yang; Thomas R. Beattie; Tsung-Ying Shen

Abstract Synthesis of 1-fluoro-1-deoxyscylloinositol and 2-fluoro-2-deoxy-1-phosphatidylscylloinositol from myoinositol is described.


Synthetic Communications | 1988

Synthesis of 2-C-Fluoromethyl-Myo-Inositol

Shu Shu Yang; Ji Mei Min; Thomas R. Beattie

Abstract Synthesis of 2-C-fluoromethyl-myo-inositol from DL-l-O-benzyl-2-oxiranyl-3, 4, 5, 6-tetra-O-benzyl-myo-inositol is described.


Tetrahedron Letters | 1990

Thermal rearrangement of the immunosuppressant FK-506

H. Ok; Byron H. Arison; R.G. Ball; Thomas R. Beattie; Michael H. Fisher; Matthew J. Wyvratt

Treatment of FK-506 in xylene at reflux results in a [3,3] sigmatropic rearrangement of the allylic ester portion of the molecule to give a new ring expanded macrolide.


Bioorganic & Medicinal Chemistry Letters | 1997

C32-amino derivatives of the immunosuppressant ascomycin

Hyun O. Ok; John Szumiloski; Thomas R. Beattie; Mark T. Goulet; Mary Jo Staruch; Francis J. Dumont; Matthew J. Wyvratt

Abstract Various C32-amino derivatives were investigated as replacements for the C32-hydroxyl group of ascomycin and its C24-deoxy analog. The syntheses of these amino derivatives and their biological evaluation are reported herein.


Journal of Organic Chemistry | 1977

Aldol condensations of regiospecific penicillanate and cephalosporanate enolates. Hydroxyethylation at C-6 and C-7.

Frank P. DiNinno; Thomas R. Beattie; Burton G. Christensen


Archive | 1991

Fluoromacrolides having immunosuppressive activity

Mark T. Goulet; Thomas R. Beattie; Matthew J. Wyvratt


Archive | 1991

Aminomacrolides and derivatives having immunosuppressive activity

Hyun O. Ok; Thomas R. Beattie; Michael H. Fisher; Matthew J. Wyvratt; Mark T. Goulet


Journal of the American Chemical Society | 1972

Substituted penicillin and cephalosporin derivatives. I. Stereospecific introduction of the C-6(7) methoxy group

Lovji D. Cama; W. J. Leanza; Thomas R. Beattie; Burton G. Christensen


Archive | 1982

Phosphatidyl inositol analogs useful as anti-inflammatory/analgesic agents

Shu S. Yang; Thomas R. Beattie; Philippe L. Durette; Timothy F. Gallagher; Tsung-Ying Shen


Archive | 1990

New 2, 5-diaryl tetrahydrofurans and analogs thereof as paf antagonists

Tesfaye Biftu; San-Bao Hwang; Thomas W. Doebber; Thomas R. Beattie; Tsung-Ying Shen

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