Thomas R. Webb
Genentech
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Featured researches published by Thomas R. Webb.
Tetrahedron Letters | 1988
Thomas R. Webb
The first synthesis of 1-(2-deoxy-3-methyl-beta-D-xylosyl)thymine from the unstable 5′-O-trityl-3′-keto-2′-deoxythymidine via a novel organometallic reagent is reported. The stereochemistry at the 3′ position is conclusively determined by chemical means. Some further transformations of the title product are described.
Tetrahedron Letters | 1985
Thomas R. Webb
Abstract A regioselective one pot synthesis of 2-substituted pyridine derivatives from pyridine-1-oxides is described.
Tetrahedron Letters | 1987
Mark D. Matteucci; Thomas R. Webb
Abstract We report the synthesis of 5′ HO-dT6(N6,N6-ethanodeoxyadenosine)T14. This oligonucleotide specifically crosslinks with 5′ HO-dA14CA6T at pH 7.5 and 20°C with a half-life of approximately one day.
Nucleosides, Nucleotides & Nucleic Acids | 1983
Thomas R. Webb
Abstract A short synthesis of the title compound (1) from the nucleo-side, 5-amino-4-imidazolecarboxamide riboside (2), is reported, Treatment of 2 with phosphorus oxychloride (POCl3) in trimethyl phosphate (PO(OCH3)3), followed by the addition of bis-tri-n-butylammonium pyrophosphate and finally hydrolysis, gave 1 in good overall yield. This synthesis confirms the structure of 1 as proposed and further demonstrates the utility of this triphosphorylation procedure.
Nucleic Acids Research | 1986
Thomas R. Webb; Mark D. Matteucci
Journal of Medicinal Chemistry | 1996
Jeffrey P. Whitten; Yun Feng Xie; Philip E. Erickson; Thomas R. Webb; Errol B. De Souza; and Dimitri E. Grigoriadis; James R. McCarthy
Journal of Medicinal Chemistry | 1988
Thomas R. Webb; Hiroaki Mitsuya; Samuel Broder
Journal of Organic Chemistry | 1991
Thomas R. Webb; Charles Eigenbrot
Archive | 1989
Thomas R. Webb
Archive | 1990
Thomas R. Webb