Thomas W. Crosby

The Eaton-Lambert syndrome and autoimmune disorders

Abstract The Eaton-Lambert syndrome is a myasthenic disorder often associated with small cell carcinoma of the lung. We describe a patient with hypothyroidism and pernicious anemia in addition to this syndrome to document its association with diseases having autoimmune concomitants.

Mitochondria1 encephalomyopathy with decreased succinate‐cytochrome c reductase activity

We report two siblings with a mitochondrial encephalomyopathy. The syndrome was characterized by ataxia, intellectual impairment, myoclonic jerks, rare seizures, and small stature. Muscle biopsy specimens showed abnormal accumulations of mitochondria and lipid droplets. Biochemical studies on muscle demonstrated decreased succinate-cytochrome c reductase activity in the mitochondrial respiratory chain.