Thomas W. Mattingly

Successful Surgical Repair of a Ruptured Aneurysm of the Sinus of Valsalva

A patient is described in whom an aneurysm of the right coronary sinus of Valsalva ruptured into the right atrium. A new method of surgical closure is presented along with pertinent physiologic data obtained before and after operation.

Pheochromocytoma and the abnormal electrocardiogram

Abstract 1. 1. Two patients with pheochromocytoma and abnormal electrocardiograms due to the presence of this tumor are reported. Serial tracings illustrating the effects of surgery, as well as the administration of adrenolytic agents, are presented. 2. 2. Pertinent literature is reviewed, and it is observed that the association of pheochromocytoma and electrocardiographic abnormalities has been previously noted though recently neglected. 3. 3. The reported abnormalities are either arrhythmias or changes suggesting myocardial damage, ischemia, or “strain.” A singularly striking feature of the latter group is the diffuse distribution of the S-T segment and T-wave changes. 4. 4. The role of excessive circulating epinephrine and/or norepinephrine in the production of these changes is discussed. 5. 5. It is emphasized that in the absence of known etiology certain electrocardiographic abnormalities may indicate the presence of a pheochromocytoma.

Stress Tests in the Detection of Coronary Disease

(1958). Stress Tests in the Detection of Coronary Disease. Postgraduate Medicine: Vol. 24, No. 4, pp. 419-430.

Clinical experience with sympathetic blocking agents in peripheral vascular disease.

Excerpt During the last five years numerous agents capable of blocking the sympathetic nervous system have been utilized in the study and treatment of peripheral vascular disease.1-8Although these ...

Recurrent ventricular tachycardia as the chief manifestation of myocarditis of unknown etiology.

Abstract The case of a 19-year-old patient with multifocal premature ventricular contractions and frequent bouts of ventricular tachycardia culminating fatally, with pathologic findings of myocarditis, is presented. This patient had little other clinical evidence of cardiac disease. Other causes of ventricular tachycardia are discussed and other cases of myocarditis of known and unknown etiology with ventricular tachycardia are reviewed. It is pointed out that ventricular tachycardia can be the predominant manifestation of myocarditis, and the possibility is suggested that cases of ventricular tachycardia with no apparent heart disease may represent less serious forms of myocarditis. Some possibilities as to the mechanism of ventricular tachycardia are mentioned. Possible causes for the myocarditis in this case are discussed briefly.

Acquired Arteriovenous Fistulas Complicated by Endarteritis, and Endocarditis Lenta Due to Streptococcus faecalis

THE occurrence of an acquired arteriovenous fistula complicated by both bacterial endocarditis and endarteritis is unusual. Although 20 cases of traumatic arteriovenous fistula with associated bact...

A Long-Term Evaluation of the Postexercise Electrocardiogram in the Prediction of Coronary Artery Disease.

Excerpt In 1952 a prospective study was initated at Walter Reed General Hospital to determine if a postexercise electrocardiogram stress test could detect latent coronary artery disease in the clin...