Thomas W. Smith
University of California, San Diego
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Publication
Featured researches published by Thomas W. Smith.
Jacc-cardiovascular Interventions | 2008
Ehtisham Mahmud; Thomas W. Smith; Vachaspathi Palakodeti; Owais Zaidi; Lawrence Ang; C. Robinson Mitchell; Nayab Zafar; Guilherme Bromberg-Marin; Shahin Keramati; Sotirios Tsimikas
OBJECTIVESnThis study sought to identify angiographic parameters of favorable clinical response to renal artery stenting.nnnBACKGROUNDnStenting improves blood pressure (BP) control in patients with renal artery stenosis (RAS), but markers predicting a favorable clinical response are limited.nnnMETHODSnRenal perfusion was quantified in hypertensive patients (BP >or=140/90 mm Hg) without RAS by determining renal frame count (RFC) (angiographic frames [30 frames/s] for contrast to reach distal renal parenchyma after initial renal artery opacification) and renal blush grade (RBG) (0: none, 1: minimal, 2: normal, 3: hyperemic parenchymal blush). It was hypothesized that stenting unilateral RAS in hypertensive patients would result in decreased RFC and increased RBG, which might predict BP reduction.nnnRESULTSnThe RFC in 17 consecutive hypertensive patients without RAS (control group) (64.4 +/- 14.2 years, 12 male, 22 kidneys) was 20.1 +/- 5.4, whereas RBG was 2.33 +/- 0.66. In 24 consecutive hypertensive patients with unilateral RAS (study group) (72.7 +/- 11.3 years, 8 male), reduced RFC (26.6 +/- 9.1 to 21.4 +/- 6.7, p < 0.001) and increased RBG (1.63 +/- 0.71 to 2.13 +/- 0.85, p = 0.03) were observed after renal stenting. At 6 months, reduced BP (systolic BP 150.6 +/- 15.6 mm Hg to 128.6 +/- 15.5 mm Hg, p < 0.001; diastolic BP 77.2 +/- 15.6 mm Hg to 68.3 +/- 10.4 mm Hg, p = 0.022) without change in number of hypertensive medications was observed. Clinical responders (systolic BP reduction >15 mm Hg) had a greater decrease in RFC (7.7 +/- 4.6 vs. 1.7 +/- 5.1, p = 0.009) and 78.6% of patients with >4 RFC decrease were responders (p = 0.024).nnnCONCLUSIONSnThis study shows that quantitative indices of renal perfusion (RFC and RBG) are impaired in patients with RAS and improve after stenting, and that RFC reduction is associated with BP reduction.
Jacc-cardiovascular Interventions | 2018
Jason H. Rogers; Walter D. Boyd; Thomas W. Smith; Adrian Ebner; Steven F. Bolling
Because multiple mechanistic etiologies of mitral regurgitation (MR) frequently coexist, there has been interest in combining or sequentially staging transcatheter approaches to eliminate MR. Combined therapies can be performed together at the time of initial treatment, or they can be staged for the
Catheterization and Cardiovascular Interventions | 2018
Matthew S. Glassy; Gaurav Sharma; Gagan D. Singh; Thomas W. Smith; Dali Fan; Jason H. Rogers
To compare left atrial appendage (LAA) angiography to transesophageal echocardiography (TEE) for assessing usable LAA depth.
Catheterization and Cardiovascular Interventions | 2018
Jason H. Rogers; Benjamin Stripe; Gagan D. Singh; Walter D. Boyd; Dali Fan; Thomas W. Smith
The purpose of this study is to describe the initial clinical experience with a steerable transseptal needle (STSN) for left‐sided structural heart procedures.
Archive | 2019
Gagan D. Singh; Thomas W. Smith; Jason H. Rogers
Archive | 2019
Jason H. Rogers; Gagan D. Singh; Thomas W. Smith
Archive | 2019
Gagan D. Singh; Thomas W. Smith; Jason H. Rogers
Archive | 2019
Thomas W. Smith; Gagan D. Singh; Jason H. Rogers
Jacc-cardiovascular Interventions | 2018
Jeong Won Choi; Kwame Bodor-Tsia Atsina; Benjamin Stripe; Garrett B. Wong; Thomas W. Smith; Jason H. Rogers; Chin Shang Li; Gagan D. Singh; Walter Douglas Boyd; Paul A. Perry; Jeffrey A. Southard
Jacc-cardiovascular Interventions | 2018
Jeong Won Choi; Kwame Bodor-Tsia Atsina; Benjamin Stripe; Matthew Lam; Jesse John Goitia; Pooja Prasad; Thomas W. Smith; Garrett B. Wong; Ching-Shang Li; Walter Douglas Boyd; Paul A. Perry; Jeffrey A. Southard