Thor Ueland
Uppsala University
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Publication
Featured researches published by Thor Ueland.
Open Heart | 2018
Thor Ueland; Ola Kleveland; Annika Elisabeth Michelsen; Rune Wiseth; Jan Kristian Damås; Pål Aukrust; Lars Gullestad; B. Halvorsen; Arne Yndestad
Objective It is unclear if activation of inflammatory pathways regulates proprotein convertase subtilisin-kexin type 9 (PCSK9) levels. Approach We evaluated (1) the temporal course of serum PCSK9 during hospitalisation following acute coronary syndrome and associations with markers of inflammation (leucocyte counts, interleukin (IL)-6, C-reactive protein) and lipid levels and (2) the effect of inhibition of IL-6 signalling with the IL-6 receptor antibody tocilizumab on PCSK9 levels in a randomised, double-blind, placebo-controlled trial release in patients with non-ST-elevation myocardial infarction. Results Serum PCSK9 increased during the acute phase and this response was modestly associated with neutrophil counts (r=0.24, p=0.009) and presence of hypercholesterolaemia (r=0.019, p=0.045), but was not modified by tocilizumab. However, a modifying effect of tocilizumab on PCSK9 levels was observed in patients with hypercholesterolaemia (p=0.024, repeated measures analysis of variance) and this effect was strongly correlated with the decrease in neutrophils (r=0.66, p=0.004). Conclusions Our study suggests that patients with a more atherogenic profile may benefit from anti-IL-6 therapy with regard to PCSK9. Trial registration number NCT01491074.
Journal of the American College of Cardiology | 2015
Lars Wallentin; Annika E. Michelsen; Pål Aukrust; Richard Becker; Maria Bertilsson; Andrzej Budaj; Jan H. Cornel; Anders Himmelmann; Steen Husted; Agneta Siegbahn; Robert Storey; Frederic Kontny; Thor Ueland
Activated Leukocyte Cell Adhesion Molecule (ALCAM) And Outcomes In Acute Coronary Syndromes : A Plato Biomarker Substudy
Archive | 2001
Pål Aukrust; Stig S. Frøland; Svein Simonsen; Halfdan Aass; Jan Fjeld; Arne K. Andreassen; Halfdan Ihlen; John K. Kjekshus; Sigurd Nitter-Hauge; Thor Ueland; Lars Gullestad; Egil Lien
Archive | 2015
Arne K. Andreassen; Ole-Gunnar Anfinsen; Geir Christensen; Pål Aukrust; Ivar Sjaastad; Turid M. Pedersen; Arne Yndestad; Karl-Otto Larsen; Erik Øie; Thor Ueland; Camilla Smith; Martin Lipp; Ole Henning; B. Halvorsen; Jing Jia; Cathrine Husberg; Sofia Jonasson; Ingeborg Løstegaard; Navessa P. Tania; Martina Schmidt; Reinoud Gosens
European Heart Journal | 2014
Thor Ueland; Annika E. Michelsen; Pål Aukrust; Richard C. Becker; Maria Bertilsson; Stefan James; Agneta Siegbahn; Robert F. Storey; Lars Wallentin
European Heart Journal | 2014
Thor Ueland; Pål Aukrust; Annika E. Michelsen; Richard C. Becker; Maria Bertilsson; Anders Himmelmann; Stefan James; Agneta Siegbahn; Lars Wallentin
European Heart Journal | 2014
Thor Ueland; Pål Aukrust; Annika E. Michelsen; Maria Bertilsson; Stefan James; Anders Himmelmann; Agneta Siegbahn; Robert F. Storey; Lars Wallentin
16th European Congress of Endocrinology | 2014
Nicoleta Cristina Olarescu; Ansgar Heck; Kristin Godang; Thor Ueland; Jens Bollerslev
Archive | 2013
Harald L. Lindberg; Rune Eggum; Thor Ueland; Tom Eirik Mollnes; Vibeke Videm; Pål Aukrust; Arnt E. Fiane
Archive | 2010
Camilla Smith; Johan Herlitz; Pål Aukrust; Marianne Hartford; Kenneth Torbjorn Omland; Thor Ueland; Anna M. Jansson; Anita Persson; Thomas Karlsson
