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Featured researches published by Thorkild Friis.


Clinica Chimica Acta | 1987

Serum lipids in hyper- and hypothyroidism before and after treatment

Thorkild Friis; Laurids R Pedersen

Total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), triglycerides (TG) and apoprotein A (Apo A) were determined in serum from 21 hyperthyroid patients and 11 hypothyroid patients before and after treatment to euthyroid state. The above-mentioned components were also determined in a reference population. In the hyperthyroid group the concentration of total cholesterol and low density lipoprotein-cholesterol increased significantly upon treatment. High density lipoprotein also increased except for 9 patients also receiving propranolol. The ratio between high density lipoprotein-cholesterol and total cholesterol decreased in the patients receiving propranolol. In the hypothyroid group the values after treatment decreased significantly for cholesterol, high density lipoprotein-cholesterol and low density lipoprotein-cholesterol. The ratio between high density lipoprotein-cholesterol and total cholesterol was unchanged.


Journal of Endocrinological Investigation | 1988

Thyroid function in patients with Pendred's syndrome

J. Friis; T. Johnsen; Ulla Feldt-Rasmussen; Karine Bech; Thorkild Friis

Thyroid function was studied in 17 unrelated patients with Pendred’s syndrome. Fourteen patients had been treated with L-thyroxine, which was withdrawn during the investigation. Eight of the patients had previously had a thyroid resection. Thirteen patients had goiter at the time of study. The serum total thyroxine and serum total triiodothyronine concentrations were normal in 8, of whom 3 had elevated serum TSH concentrations. In the remaining 9 cases the thyroxine levels were below normal with elevated TSH. Serum reverse triiodothyronine concentrations were decreased in 8 out of 11. Median serum thyroglobulin was 973 μg/l (range 10.9–3200 μg/1) and increased in 13. Three patients had slightly positive thyroglobulin antibodies and one with normal level was thyrodectomized. Thyroid stimulating antibodies as measured by adenylate cyclase stimulation (median 114%, range 85–137%) were slightly increased in 11. When measured as TSH binding inhibiting immunoglobulins none were positive. Thyroid microsomal antibodies were negative in all. All patients with a detectable 131I uptake (n = 15) showed a pathological iodide perchlorate discharge test (median 32%, range 16–46%). These findings indicate an organification defect with impaired hormone synthesis.


Clinical Endocrinology | 1982

METABOLIC CLEARANCE AND PRODUCTION RATES OF 3,3′‐DIIODOTHYRONINE, 3′,5′‐DIIODOTHYRONINE AND 3′‐MONOIODOTHYRONINE IN HYPER‐ AND HYPOTHYROIDISM

J. Faber; I. B. Lumholtz; C. Kirkegaard; Kaj Siersbæk-Nielsen; Thorkild Friis

Complete turnover studies of thyroxine (T4), 3,5,3′‐triiodothyronine (T3), 3,3′,5′‐triiodothyronine (rT3), 3,3′‐diiodothyronine (3,3′‐T2), 3′,5′‐diiodothyronine (3′,5′‐T2) and 3′‐monoiodothyronine (3′‐T1) were performed in each of eight healthy subjects, eight hyperthyroid and eight hypothyroid patients, using the single injection, non‐compartmental approach. The median metabolic clearance rate (litre per day per 70 kg) in controls was, T4 1·19; T3 19·7. rT3 147; 3,3′‐T2 1073; 3′,5′‐T2 256 and 3′‐T1 518. Hyperthyroid patients had increased and hypothyroid patients reduced values. The median production rate (PR) (nmol per day per 70 kg) in controls was, T4 117, T3 39, rT3 52, 3,3′‐T2 35, 3′,5′‐T2 14 and 3′‐T1 27. The PR of all iodothyronines studied was increased in hyperthyroidism, the increase in PR of T3 being the most pronounced. Hypothyroid patients had reduced PRs, a reduction which was relatively less pronounced for T3. Assuming thyroidal secretion contributes little rT3 and 3′,5′‐T2, the conversion rates (CRs) of T4 to rT3 and further to 3′,5′‐T2 were calculated. CR of T4 to rT3 in controls was in median 34%. By comparison the CR in hyperthyroid patients was increased to 56% (P < 0·05). In contrast the CR of rT3 to 3′,5′‐T2 was similar in controls and hyperthyroid patients, 26% v. 31%.


Annals of Clinical Biochemistry | 1997

Microalbuminuria in Type 2 Diabetic Patients: A Prospective Follow-Up Study

Thorkild Friis; Laurids R Pedersen

We have studied 46 patients, 30 men and 16 women, with type 2 (noninsulin-dependent) diabetes in a follow-up period of 6–52 months (mean 30 months). The patients were consecutively entered in the study from the out-patient diabetic clinic. None had urinary tract infections nor proteinuria at entry. Investigations were done every 3 months during the first year and after that every 6 months. At entry 16 patients (35%) had microalbuminuria and a further 16 patients developed microalbuminuria and 16 proteinuria. The systolic blood pressure was higher in men with microalbuminuria compared to men without microalbuminuria. The glomerular filtration rate decreased with time for patients with microalbuminuria without change in plasma creatinine. The C-peptide concentration was higher in the hypertensive patients compared to non-hypertensive and the same was found for the triglyceride concentration. During the observation period the various complications increased in frequency (retinopathy, cardiomyopathy, neuropathy, angiopathy and hypertension) without significant relation to the presence of microalbuminuria or proteinuria. During the observation period nine patients died mainly due to cardiovascular events.


Annals of Clinical Biochemistry | 1994

Microalbuminuria in Type 2 Diabetic Patients: A Cross-Sectional Study of Frequency, Sex Distribution and Relation to Hypertension

Thorkild Friis; Laurids R Pedersen; Susanne Arnold-Larsen; Dorthe B Nielsen

We studied 112 type 2 diabetic patients. Fourteen patients had frank proteinuria, and 37 of the remaining 98 had microalbuminuria which was more frequent in men than in women (P<0·02). Hypertension was found in 47 of the patients, equally distributed between sexes. Male diabetics with microalbuminuria had higher systolic blood pressure than diabetics without microalbuminuria (P<0·02). Body mass index was higher in both sexes with hypertension compared to patients without hypertension. In the hypertensive men plasma C-peptide values were higher compared to patients without hypertension (P<0·01) irrespective of the presence of microalbuminuria. A positive correlation between blood pressure and C-peptide was found (P<0·01) in the men. We suggest that gender should be taken into account in the analysis and interpretation of microalbuminuria in type 2 diabetes.


Journal of Endocrinological Investigation | 1983

The prognostic value of parallel measurements of thyrotropin binding inhibiting immunoglobulins (TBII) and thyroid adenylate cyclase stimulating antibodies (TSAb) in Graves’ disease after longterm antithyroid treatment

Henning Bliddal; Karine Bech; Kaj Siersbæk-Nielsen; Thorkild Friis

Thyroid stimulating immunoglobulins were measured in 43 patients with Graves’ disease both before and at the end of longterm antithyroid treatment. Parallel determinations were performed of thyrotropin binding inhibiting immunoglobulins (TBII) and thyroid adenylate cyclase stimulating antibodies (TSAb). Before treatment 33 patients were TBII positive and 32 TSAb positive, and at the end of treatment 19 remained TBII positive and 14 TSAb positive. The frequency of relapse was about 70% in the positive patients and about 40% in the patients, who became negative in either test for thyroid stimulating immunoglobulins. By combination of the two assays 23 patients were positive in both before treatment. In these patients 5 relapsed of the 6 who remained positive for both, while none relapsed of the 5 patients, who became negative during treatment. In the remaining 12 patients either TBI I or TSAb became negative during treatment and 7 of these relapsed. It is concluded, that the combined measurement of TBII and TSAb in this study seemed superior to the separate determinations of either activity in predicting relapse after medical treatment of Graves’ disease, though this evaluation was only possible in part of the patients.


Calcified Tissue International | 1968

The effect of aluminum hydroxide in serum calcium, serum phosphorus and calcium turnover in uraemic patients

Thorkild Friis; Eva Weeks

In 11 normal persons and 16 uraemic patients serum calcium, serum phosphorus and calcium pool = exchangeable calcium are determined (Heaney and Whedon~ 1958). Among the 16 uraemic patients 8 had inuJlnclearance ,20 ml/mln. i 5 between 20 and 40 ml/mi~, and 3 >40 ml/min. 9 of the uraemlc patients had serum calcium below normal (inu linclearance z. 40 ml/min.) and 6 serum phosphorus above the normal range {inulinclearance L, 20 ml/mln.). 10 had abnormal x--ray photos of the column and the skull {hal[steresis, fractures). 14 had chronic pyelonephrltls, 1 renal tubular acidosis and 1 had cysts of the kidney. The exchangeable calcium was 59.9+ 13.9 mg/kg in the normals and 77.6 + 39.4 mg/kg ~n the uraemic patients; the difference was not significant. The patients with severe halisteresls had the highest exchangeable calcium.


The Journal of Clinical Endocrinology and Metabolism | 1981

Kinetic Studies of Thyroxine, 3,5,3′-Triiodothyronine, 3,3′,5′-Triiodothyronine, 3′,5′-Diiodothyronine, 3,3′-Diiodothyronine, and 3′-Monoiodothyronine in Patients with Liver Cirrhosis

J. Faber; H. Francis Thomsen; I. B. Lumholtz; C. Kirkegaard; Kaj Siersbæk-Nielsen; Thorkild Friis


Clinical Endocrinology | 1982

PRODUCTION OF NON‐STIMULATORY IMMUNOGLOBULINS THAT INHIBIT TSH BINDING IN Graves' DISEASE AFTER RADIOIODINE ADMINISTRATION

Karine Bech; Henning Bliddal; Kaj Siersbæk-Nielsen; Thorkild Friis


The Lancet | 1975

Letter: Does T4 toxicosis exist?

C. Kirkegaard; Kaj Siersbæk-Nielsen; Thorkild Friis; P. Rogowski

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J. Faber

Frederiksberg Hospital

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Jens Faber

University of Copenhagen

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Henning Bliddal

Copenhagen University Hospital

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Karine Bech

Frederiksberg Hospital

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Rogowski P

Frederiksberg Hospital

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