Tibor Novák

Benefits of Periodontal Therapy When Preterm Birth Threatens

There is growing evidence that chronic periodontitis may be a risk factor for pre-term birth. The goal of this intervention study was to determine the effect of periodontal treatment on the pregnancy outcome in women with threatening pre-term birth and initial localized chronic periodontitis. Forty-one women with a singleton pregnancy were enrolled in the study. For this treatment group, oral hygiene instruction and periodontal therapy were provided in the third trimester, while those in the control group (42 persons) did not receive any periodontal treatment. In the treatment group, the mean weight of newborns was 3079.0 g, compared with the control group mean of 2602.4 g. The incidence of pre-term birth and low birthweight in the treatment group was significantly less than in the control group (p = 0.015). Periodontal treatment completed before the 35th week appeared to have a beneficial effect on birth weight and time of delivery.

Prevention of preterm delivery with periodontal treatment

Objective: To demonstrate the role of periodontal treatment (PT) in the prevention of preterm delivery (PD). Methods: A comparative prospective study of two groups of pregnant women with threatening PD was carried out at the Department of Obstetrics and Gynaecology of the University of Szeged: group A (n = 39) comprised patients who were merely examined dentally for periodontitis, and group B (n = 44) consisted of patients who received periodontal treatment during pregnancy. Results: Periodontitis was identified in 19 cases (48.7%) in group A and in 18 cases (40.9%) in group B. The mean birth weight of the newborns was significantly higher in group B (3,009.1 g) than in group A (2,580.8 g; p = 0.007). The rate of premature birth was significantly lower in the group who received PT (p = 0.012, odds ratio = 3.5, 95% confidence interval = 1.38–8.86). Conclusions: The PT of pregnant women can decrease the rate of premature birth and consequently lead to a better neonatal health outcome.

Fogágybetegség kezelésének hatása a terhesség kimenetelére

INTRODUCTION Correlations between periodontitis and its effects on the outcome of pregnancies are actually more focused topics. Maternal motivation for a good oral hygiene and preventive dental treatment must be highlighted tasks during pregnancy care. AIM The authors analysed the effect of the preventive dental treatment during pregnancy and its obstetrical effects. METHOD In a prospective randomised study, including pregnant women observed for threatening preterm deliveries, patients with dental examination (n = 71) were compared with patients undergoing dental treatment at the same time (n = 79). STATISTICAL ANALYSIS Univariate comparisons for categorical variables were assessed by χ2 tests and independent Students t-tests for continuous variables. ORs were compared with Mantel-Haenszel tests. Multivariable logistic regression was performed to evaluate the factors determining the poor periodontal parameters and gingivitis separately. The two-tailed statistical significance level was set at 5%. RESULTS In the dental treatment group, the neonatal birth weight was significantly higher than in the non-treated group, in case of patients with periodontitis (2990 ± 582.3 g vs 2568.1 ± 699.1 g, p = 0.005). Also the average age at delivery was significantly higher in the treated vs non-treated groups (37.3 ± 1.9 vs 36.0 ± 2.9 weeks, p = 0.027), and the treatment had a beneficial effect on the prolongation of pregnancy, with a higher level of significance in the gingivitis group vs patients with periodontitis groups (p = 0.02 vs p = 0.043). CONCLUSIONS Dental treatment of expecting women has a beneficial effect on the prolongation of pregnancy by decreasing the rate of prematurity and perinatal complications. Orv Hetil. 2018; 159(24): 978-984.Absztrakt: Bevezetes: A terhesseg alatti fogagybetegsegek es az azok szuleszeti kovetkezmenyei kozotti osszefuggesek elemzese egyre szelesebb korben kutatott es bővulő temakor. A paciensek megfelelő szajhigienia iranti motivacioja es szukseges esetben a biztonsagosan es hatekonyan kivitelezhető professzionalis szajhigienes kezelesek kiemelt pontjai kell, hogy legyenek a varandosgondozasnak. Celkitűzes: A jelen tanulmanyban a terhesseg alatt elvegzett professzionalis szajhigienes kezeles hatasait elemeztuk, szuleszeti szempontokbol. Modszer: A szerzők a fenyegető koraszules miatt megfigyelt terhesek eseteben prospektiv randomizalt tanulmanyban vetettek ossze a csak fogaszati szűresen (n = 71), illetve ezzel egy időben fogaszati kezelesen is (n = 79) atesett varandosok szuleszeti mutatoit. Statisztikai analizis: A kezelt es nem kezelt csoportok egyszerű osszehasonlitasat kategorikus valtozok eseteben khi-negyzet-, mig folytonos valtozok eseteben t-probaval vegeztuk. A perinatologiai kimenetel kategorikus fa...

TestSTORM: Versatile simulator software for multimodal super-resolution localization fluorescence microscopy

Optimization of sample, imaging and data processing parameters is an essential task in localization based super-resolution microscopy, where the final image quality strongly depends on the imaging of single isolated fluorescent molecules. A computational solution that uses a simulator software for the generation of test data stacks was proposed, developed and tested. The implemented advanced physical models such as scalar and vector based point spread functions, polarization sensitive detection, drift, spectral crosstalk, structured background etc., made the simulation results more realistic and helped us interpret the final super-resolved images and distinguish between real structures and imaging artefacts.

Enhanced simulator software for image validation and interpretation for multimodal localization super-resolution fluorescence microscopy

Optical super-resolution techniques such as single molecule localization have become one of the most dynamically developed areas in optical microscopy. These techniques routinely provide images of fixed cells or tissues with sub-diffraction spatial resolution, and can even be applied for live cell imaging under appropriate circumstances. Localization techniques are based on the precise fitting of the point spread functions (PSF) to the measured images of stochastically excited, identical fluorescent molecules. These techniques require controlling the rate between the on, off and the bleached states, keeping the number of active fluorescent molecules at an optimum value, so their diffraction limited images can be detected separately both spatially and temporally. Because of the numerous (and sometimes unknown) parameters, the imaging system can only be handled stochastically. For example, the rotation of the dye molecules obscures the polarization dependent PSF shape, and only an averaged distribution – typically estimated by a Gaussian function – is observed. TestSTORM software was developed to generate image stacks for traditional localization microscopes, where localization meant the precise determination of the spatial position of the molecules. However, additional optical properties (polarization, spectra, etc.) of the emitted photons can be used for further monitoring the chemical and physical properties (viscosity, pH, etc.) of the local environment. The image stack generating program was upgraded by several new features, such as: multicolour, polarization dependent PSF, built-in 3D visualization, structured background. These features make the program an ideal tool for optimizing the imaging and sample preparation conditions.