Tiejian Wu

Relationship of Alcohol Drinking Pattern to Risk of Hypertension: A Population-Based Study

Epidemiological studies have demonstrated a positive relationship between heavy alcohol use and hypertension, but few studies have directly addressed the role of drinking pattern. This study was designed to investigate the association of current alcohol consumption and aspects of drinking pattern with hypertension risk in a sample of 2609 white men and women from western New York, aged 35 to 80 years, and free from other cardiovascular diseases. Hypertension was defined by systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg or use of antihypertensive medication. Odds ratios (95% confidence intervals) were computed after adjustment for several covariates. Compared with lifetime abstainers, participants reporting drinking on a daily basis (1.75 [1.13 to 2.72]) or mostly without food (1.64 [1.08 to 2.51]) exhibited significantly higher risk of hypertension. When analyses were restricted to current drinkers, daily drinkers and participants consuming alcohol without food exhibited a significantly higher risk of hypertension compared with those drinking less than weekly (1.65 [1.18 to 2.30]) and those drinking mostly with food (1.49 [1.10 to 2.00]), respectively. After additional adjustment for the amount of alcohol consumed in the past 30 days, the results were follows: 0.90 (0.58 to 1.41) for daily drinkers and 1.41 (1.04 to 1.91) for drinkers without food. For predominant beverage preference, no consistent association with hypertension risk was found across the various types of beverages considered (beer, wine, and liquor). In conclusion, drinking outside meals appears to have a significant effect on hypertension risk independent of the amount of alcohol consumed.

Serum iron, copper and zinc concentrations and risk of cancer mortality in US adults.

PURPOSE To examine the prospective association of serum iron, copper, and zinc with cancer mortality. METHODS The study sample included 3000 men and 3244 women free from cancer at baseline who participated in the Second National Health and Nutrition Examination Survey. Vital status at follow-up was identified by the Social Security Administrations death file and the National Death Index. Iron, transferrin saturation (TS), copper, and zinc were categorized into 4 levels using the 10th, 50th, and 90th percentiles for cutoffs. Relative risks (RRs) were derived from the proportional hazard models after adjustment for a number of potential confounders. RESULTS Three hundred seven cancer deaths (ICD-9 140-195, 199-208) were identified during 83,664.4 person-years of follow-up. Cancer mortality per 1000 person-years was 3.7 (4.7 for men and 2.8 for women). For men and women combined, the adjusted RRs (95% confidence intervals, CI) for the four levels were 0.96 (0.57-1.61), 1.00 (reference), 1.12 (0.80-1.58), 1.86 (1.07-3.22) for iron; 0.97 (0.56-1.70), 1.00 (reference), 1.36 (0.99-1.87), 1.82 (1.10-3.02) for TS; 0.76 (0.44-1.31), 1.00 (reference), 1.10 (0.77-1.58), 1.89 (1.07-3.32) for copper; and 0.75 (0.50-1.13), 1.00 (reference), 0.64 (0.47-0.88), 0.84 (0.53-1.33) for zinc. When the exposures were analyzed as continuous variables, the adjusted RRs (CI) were 1.66 (1.03-2.68) for 100 microg/dl iron increase, 1.17 (1.01-1.36) for 10% TS increase, 1.98 (1.12-3.50) for 100 microg/dl copper increase, and 0.57 (0.16-1.96) for 100 microg/dl zinc increase. Sex differences in the adjusted RRs for iron, TS, and copper were suggestive. CONCLUSION People with higher serum iron, TS, or copper concentrations had an increased risk of dying from cancer.

Can Regular Multivitamin/Mineral Supplementation Modify the Relation between Maternal Smoking and Select Adverse Birth Outcomes?

PURPOSE The purpose of this study was to examine whether or not regular multivitamin/mineral supplementation can modify the relation between maternal smoking and preterm birth (gestational age < 37 weeks), very-low-birthweight (VLBW) (< 1500 g), moderately-low-birthweight (MLBW) (< 2499 g), or small-for-gestational-age (SGA) (< 10th percentile of birth weight for gestational age). METHODS Live birth data from the 1988 National Maternal and Infant Health Survey (NMIHS) were used for the analysis. Maternal smoking referred to self-reported average number of cigarettes smoked after recognition of pregnancy, while regular multivitamin/mineral supplementation referred to use of multivitamin/mineral supplements for at least three days per week during the three months before and/or after recognition of pregnancy. Sample sizes included 9402 singleton infants for the analysis of preterm birth, 9395 for very or moderately low birthweight, and 9363 for small-for-gestational-age. Odds ratios were derived from logistic regression analyses after adjusting for a number of demographic and reproductive variables. RESULTS Major results include: 1) increased risks for the adverse outcomes studied were observed among smoking women; 2) no effect of regular multivitamin/mineral supplementation in the absence of maternal smoking was revealed; and 3) relative excess risks due to interaction at different smoking levels and overall interactions between smoking and supplementation were not observed. CONCLUSIONS These results suggest that regular multivitamin/mineral supplementation does not minimize the adverse effects associated with maternal smoking.

Side effects and discontinuation rates of intrauterine contraceptive device use in the Jilin Province of China.

Data from the Fertility and Contraception Survey undertaken in the Jilin Province in 1988 were used to examine both the rates of side effects and discontinuation among women using intrauterine devices (IUDs). The results show that among the 1, 912 first time IUD users, the combined side effects rate comprising excessive bleeding, irregular menstruation, or abdominal pain was 11.7 percent; 0.2 percent of first time IUD users became seriously ill due to faulty insertion techniques. The gross cumulative failure rates at the end of the first, second and third year following insertion were 5.3%, 9.2% and 11.9%, respectively. Total gross cumulative discontinuation rates for these three time periods were 9.9%, 19.3%, and 28.3%, respectively. It was also found that selected social and service factors such as nationality, farm/non-farm residency, medical institution where the insertion was provided, interval between the date of last pregnancy and the date of the insertion, and the number of children at the time of insertion were associated with IUD-related side effects and/or discontinuation. The Findings are further discussed with respect to governmental intervention in regulating family size, in terms of the reliability of the self-reported data, and other IUD related effects.