Tieyan Si

Near-infrared light-triggered "on/off" motion of polymer multilayer rockets.

We describe an approach to modulating the on-demand motion of catalytic polymer-based microengines via near-infrared (NIR) laser irradiation. The polymer multilayer motor was fabricated by the template-assisted layer-by-layer assembly and subsequently deposition of platinum nanoparticles inside and a thin gold shell outside. Then a mixed monolayer of a tumor-targeted peptide and an antifouling poly(ethylene glycol) was functionalized on the gold shell. The microengines remain motionless at the critical peroxide concentration (0.1%, v/v); however, NIR illumination on the engines leads to a photothermal effect and thus rapidly triggers the motion of the catalytic engines. Computational modeling explains the photothermal effect and gives the temperature profile accordingly. Also, the photothermal effect can alone activate the motion of the engines in the absence of the peroxide fuel, implying that it may eliminate the use of toxic fuel in the future. The targeted recognition ability and subsequently killing of cancer cells by the photothermal effect under the higher power of a NIR laser were illustrated. Our results pave the way to apply self-propelled synthetic engines in biomedical fields.

Near‐Infrared‐Activated Nanocalorifiers in Microcapsules: Vapor Bubble Generation for In Vivo Enhanced Cancer Therapy

Photothermal therapy based on gold nanostructures has been widely investigated as a state-of-the-art noninvasive therapy approach. Because single nanoparticles cannot harvest sufficient energy, self-assemblies of small plasmonic particles into large aggregates are required for enhanced photothermal performance. Self-assembled gold nanorods in lipid bilayer-modified microcapsules are shown to localize at tumor sites, generate vapor bubbles under near-infrared light exposure, and subsequently damage tumor tissues. The polyelectrolyte multilayer enables dense packing of gold nanorods during the assembly process, which leads to the formation of vapor bubbles around the excited capsules. The resulting vapor bubbles achieve a high efficiency of suppressing tumor growth compared to single gold nanorods. In vivo experiments demonstrated the ability of soft-polymer multilayer microcapsules to cross the biological barriers of the body and localize at target tissues.

Recent Progress on Bioinspired Self‐Propelled Micro/Nanomotors via Controlled Molecular Self‐Assembly

The combination of bottom-up controllable self-assembly technique with bioinspired design has opened new horizons in the development of self-propelled synthetic micro/nanomotors. Over the past five years, a significant advances toward the construction of bioinspired self-propelled micro/nanomotors has been witnessed based on the controlled self-assembly technique. Such a strategy permits the realization of autonomously synthetic motors with engineering features, such as sizes, shapes, composition, propulsion mechanism, and function. The construction, propulsion mechanism, and movement control of synthetic micro/nanomotors in connection with controlled self-assembly in recent research activities are summarized. These assembled nanomotors are expected to have a tremendous impact on current artificial nanomachines in future and hold potential promise for biomedical applications including drug targeted delivery, photothermal cancer therapy, biodetoxification, treatment of atherosclerosis, artificial insemination, crushing kidney stones, cleaning wounds, and removing blood clots and parasites.

Near-infrared light-driven Janus capsule motors: Fabrication, propulsion, and simulation

We report a fuel-free, near-infrared (NIR)-driven Janus microcapsule motor. The Janus microcapsule motors were fabricated by template-assisted polyelectrolyte layer-by-layer assembly, followed by spraying of a gold layer on one side. The NIR-powered Janus motors achieved high propulsion with a maximum speed of 42 µm·s-1 in water. The propulsion mechanism of the Janus motor was attributed to the self-thermophoresis effect: The asymmetric distribution of the gold layer generated a local thermal gradient, which in turn generated thermophoretic force to propel the Janus motor. Such NIR-propelled Janus capsule motors can move efficiently in cell culture medium and have no obvious effects on the cell at the power of the NIR laser, indicating considerable promise for future biomedical applications.

Light-activated Active Colloid Ribbons

We report a dynamic self-organization of self-propelled peanut-shaped hematite motors from non-equilibrium driving forces where the propulsion can be triggered by blue light. They result in one-dimensional, active colloid ribbons with a positive phototactic characteristic. The motion of colloid motors is ascribed to the diffusion-osmotic flow in a chemical gradient by the photocatalytic decomposition of hydrogen peroxide fuel. We show that self-propelled peanut-shaped colloids readily form one-dimensional, slithering ribbon structures under the out-of-equilibrium collisions. This self-organization intrinsically results from the competition among the osmotically driven motion, the phoretic attraction and the inherent magnetic moments. The giant size number fluctuation in colloid ribbons is observed above a critical point 4.1 % of the surface density of colloid motors. Such phototactic colloid ribbons may provide a model system to understand the emergence of function in biological systems and have potential to construct bioinspired active materials based on different active building blocks.

A Light-Activated Explosive Micropropeller

Self-propelled micro/nanomotors possess tremendous exciting promise in diverse fields. We describe an asymmetric, fuel-free and near-infrared light-powered torpedo micromotor, which is constructed by using a porous membrane-assisted layer-by-layer sol-gel method to form silica multilayer inside the pores, following by the deposition of gold nanoparticles on one end of the pores. In the absence of chemical fuels, the high propulsion of microtorpedoes under illumination of near-infrared light is owing to the photo-thermal effect of gold clusters, generating a thermal gradient inside the microtorpedoes. The speed of microtorpedoes is dependent on the laser powers and media. More interestingly, such fuel free-powered microtorpedoes could explode triggered by higher laser power at the predefined site and thus provide a new platform for future biomedical applications.

Self-Propulsion: Superfast Near-Infrared Light-Driven Polymer Multilayer Rockets (Small 5/2016)

T. Si, Q. He, and co-workers demonstrate the fuel-free, highly efficient propulsion of gold nanoshell-functionalized polymeric multilayer rockets under NIR illumination. On page 577, the NIR-driven rockets, fabricated by nanoporous template-assisted polyelectrolyte layer-by-layer assembly, can move at a speed of 160 μm s(-1) owing to the self-thermophoretic forces generated by the photothermal effect. This NIR-driven rocket is able to target cancer cells without side effects on the cell under exposure to NIR, indicating considerable promise for future biomedical applications.

Bubble-Pair Propelled Colloidal Kayaker

We report a hollow dumbbell-shaped manganese dioxide (MnO2) colloidal kayaker capable of converting a pair of breathing oxygen bubbles into self-propelled movement. The bubble pair generated by catalytic decomposition of hydrogen peroxide fuel grew either synchronously or asynchronously, driving the colloidal kayaker to move along a fluctuating circle. The synchronous or asynchronous breathing mode of bubble pair is governed by the asymmetric catalytic sites of the colloidal kayakers. This imbalanced distribution of bubble propulsion force generates the driving force and the centripetal force on the colloidal kayaker. The dynamics of colloidal kayakers is well-described by the overdamped Langevin equation and fluid field simulation. Such bubble-pair propelled colloidal kayakers could advance applications of catalytic nanomotors, offering effective implementation for diverse tasks for a wide range of practical applications.