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Timothy Jon Luker

Loughborough University

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Publication

Featured researches published by Timothy Jon Luker.

Bioorganic & Medicinal Chemistry Letters | 2011

The Discovery of Novel, Potent and Highly Selective Inhibitors of Inducible Nitric Oxide Synthase (Inos).

David Cheshire; Anders Åberg; Gunilla Andersson; Glen Andrews; Haydn Beaton; Timothy Nicholas Birkinshaw; Nigel Boughton-Smith; Stephen Connolly; Tony R. Cook; Anne Cooper; Sally L. Cooper; David Loughborough Cox; John Dixon; Nigel Gensmantel; Peter Hamley; Richard Harrison; Paul Hartopp; Helena Käck; Paul D. Leeson; Timothy Jon Luker; Antonio Mete; Ian Millichip; David Nicholls; Austen Pimm; Steve St-Gallay; Alan V Wallace

By careful analysis of experimental X-ray ligand crystallographic protein data across several inhibitor series we have discovered a novel, potent and selective series of iNOS inhibitors exemplified by compound 8.

Journal of Medicinal Chemistry | 2007

Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X7 Receptor Antagonists/Interleukin-1β Inhibitors

Mark Furber; Lilian Alcaraz; Janice Bent; Armin Beyerbach; Keith Bowers; Martin Braddock; Moya Caffrey; David Cladingboel; John Collington; David Keith Donald; Malbinder Fagura; Frank Ince; Elizabeth Kinchin; Celine Laurent; Mandy Lawson; Timothy Jon Luker; Michael Mortimore; Austen Pimm; Robert J. Riley; Nicola J. Roberts; Mark J. Robertson; Jill Theaker; Philip Thorne; Richard Weaver; Peter J. H. Webborn; Paul Willis

Archive | 2008

PYRAZINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF LUNG DISEASES

Stephen Brough; Richard Evans; Timothy Jon Luker; Piotr Raubo

Archive | 2001

Novel phenylheteroazetidines, useful as nitric oxide synthase inhibitors

David Cheshire; Timothy Jon Luker; Antonio Mete

Archive | 2000

5,7-bicyclic amidine derivatives useful as nitric oxide synthase inhibitors

David Cheshire; Stephen Connolly; David Cox; Peter Hamley; Timothy Jon Luker; Antonio Mete; Austen Pimm; Michael J. Stocks

Archive | 2012

Pyrazinone derivatives, pharmaceutically acceptance salts thereof and their uses

Stephen Brough; Richard Evans; Timothy Jon Luker; Piotr Raubo

Archive | 2008

Novel Compounds 951

Roger Victor Bonnert; Timothy Jon Luker; Anil Patel; Aaron Rigby

Archive | 2017

composto 951: um ácido bifeniloxipropanoico como modulador de crth2 e intermediários

Aaron Rigby; Anil Patel; Roger Victor Bonnert; Timothy Jon Luker

Archive | 2008

Biphenyloxypropanoic acid as crth2 modulator and intermediates

Roger Victor Bonnert; Timothy Jon Luker; Anil Patel; Aaron Rigby

Archive | 2008

Neue verbindungen 951: eine biphenyloxypropansäure als crth2-modulator und zwischenprodukte

Roger Victor Bonnert; Timothy Jon Luker; Anil Patel; Aaron Rigby

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Roger Victor Bonnert

AstraZeneca

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Rukhsana Tasneem Mohammed

AstraZeneca

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Stephen Thom

Loughborough University

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Anil Patel

Loughborough University

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Mark Furber

AstraZeneca

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Lilian Alcaraz

Loughborough University

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Michael Mortimore

Loughborough University

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Stephen Brough

AstraZeneca

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Austen Pimm

Loughborough University

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Philip Thorne

Loughborough University

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