Timothy M. Turner | Researchain

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Featured researches published by Timothy M. Turner.

Bioorganic & Medicinal Chemistry | 2010

Novel acyl coenzyme A (CoA): diacylglycerol acyltransferase-1 inhibitors: synthesis and biological activities of diacylethylenediamine derivatives.

Yoshihisa Nakada; Thomas Daniel Aicher; Yvan Le Huerou; Timothy M. Turner; Scott Alan Pratt; Stephen S. Gonzales; Steve A. Boyd; Hiroshi Miki; Toshihiro Yamamoto; Hiroshi Yamaguchi; Koki Kato; Shuji Kitamura

A series of diacylethylenediamine derivatives were synthesized and evaluated for their inhibitory activity against DGAT-1 and pharmacokinetic profile to discover new small molecule DGAT-1 inhibitors. Among the compounds, N-[2-({[1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]carbonyl}amino)ethyl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide 3x showed potent inhibitory activity and excellent PK profile. Oral administration of 3x to mice with dietary-induced obesity resulted in reduced body weight gain and white adipose tissue weight.

Archive | 2004

Nitrogen-containing fused heterocyclic compounds

Albert Charles Gyorkos; Christopher Peter Corrette; Suk Young Cho; Timothy M. Turner; Scott Alan Pratt; Kazuyoshi Aso; Masakuni Kori; Michiyo Gyoten

Archive | 2008

Pyridin-2-yl-amino-1, 2, 4-thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus

Thomas Daniel Aicher; Steven Armen Boyd; Mark Joseph Chicarelli; Kevin Ronald Condroski; Jay Bradford Fell; John P. Fischer; Indrani W. Gunawardana; Ronald Jay Hinklin; Ajay Singh; Timothy M. Turner; Eli M. Wallace

Archive | 2011

Piperidinyl-substituted lactams as gpr119 modulators

Thomas Daniel Aicher; Josef Roland Benscik; Steven Armen Boyd; Kevin Ronald Condroski; Jay Bradford Fell; John P. Fischer; Ronald Jay Hinklin; Scott Alan Pratt; Ajay Singh; Timothy M. Turner

Archive | 2008

2-aminopyridine derivatives as glucokinase activators

Thomas Daniel Aicher; Steven Armen Boyd; Mark Joseph Chicarelli; Kevin Ronald Condroski; Rustam Ferdinand Garrey; Ronald Jay Hinklin; Ajay Singh; Timothy M. Turner

Archive | 2014

INTERMEDIATES FOR THE PREPARATION OF PYRIDIN-2-YL-AMINO-1,2,4-THIADIAZOLE DERIVATIVES

Archive | 2013

Compuestos derivados de lactamas sustituidas con piperidinilo, moduladores de gpr119; proceso para preparar los compuestos; composicion farmaceutica que comprende a los compuestos; y uso de los compuestos en la preparacion de medicamentos para el tratamiento o prevencion de diabetes tipo 2, obesidad y condiciones relacionadas

Thomas Daniel Aicher; Josef Roland Bencsik; Steven Armen Boyd; Kevin Ronald Condroski; Jay Bradforf; John P. Fischer; Ronald Jay Hinklin; Scott Alan Pratt; Ajay Singh; Timothy M. Turner

Archive | 2013

LACTAMAS SUSTITUIDAS POR PIPERIDINILO COMO MODULADORES DE GPR119

Timothy M. Turner; Jay Bradford Fell; Josef Roland Benscik; Ronald Jay Hinklin; Scott Alan Pratt; Thomas Daniel Aicher; Ajay Singh; John P. Fischer; Steven Armen Boyd; Kevin Ronald Condroski

Archive | 2008

Pyridin-2-yl-thiourea and Pyridin-2-yl-amine derivatives as intermediates for the preparation of Pyridin-2yl-amino-1,2,4-thiadiazole glucokinase activators

Archive | 2007

Pyridin-2-amine derivatives and their use as glucokinase activators

Thomas Daniel Aicher; Steven Armen Boyd; Mark Joseph Chicarelli; Kevin Ronald Condroski; Ronald Jay Hinklin; Ajay Singh; Timothy M. Turner; Ferdinand Garrey Rustam

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