Tirthankar Gayen

Granular Cell Tumor: An Uncommon Benign Neoplasm

Granular cell tumor is a distinctly rare neoplasm of neural sheath origin. It mainly presents as a solitary asymptomatic swelling in the oral cavity, skin, and rarely internal organs in the middle age. Histopathology is characteristic, showing polyhedral cells containing numerous fine eosinophilic granules with indistinct cell margins. We present a case of granular cell tumor on the back of a 48-year-old woman which was painful, mimicking an adnexal tumor.

Unilateral nevoid acanthosis nigricans: Uncommon variant of a common disease

Acanthosis nigricans (AN) is a fairly common dermatosis characterized by hyperpigmented velvety plaques, having a predilection for the intertriginous areas. We herein present a case of unilateral nevoid acanthosis nigricans over the left lateral chest, in an adult male. The rarity of documentation of this entity in the world literature prompted us to report the case.

Safety and effectiveness of autoinoculation therapy in cutaneous warts: A double ‑ blind, randomized, placebo ‑ controlled study

BACKGROUND In spite of the availability of multiple treatment options, viral warts are known for their persistence and recurrence, causing frustration to patients and treating physicians. AIMS To study the effectiveness and safety of autoinoculation as a treatment modality in cutaneous warts. METHODS A double-blind, placebo-controlled study was carried out. In the treatment group, full-thickness warty tissue was excised, minced and implanted in a small dermal pocket. In the control group, warty tissue was only excised and not implanted, though a dermal pocket was made. Patients were evaluated every four weeks with lesion counts. The procedure was repeated at 4 and 8 weeks. Response was assessed at each visit and at 12 weeks. RESULTS Forty-eight patients with cutaneous warts (male: female=32:16) were randomized into autoinoculation and control groups. The number of warts at baseline was comparable in both groups (P=0.293). Reduction in the number of warts was significantly more in the autoinoculation group (8.50±13.88) than in the control group (10.04±5.80) from 8 weeks onwards (P=0.010). Complete resolution occurred only in the autoinoculation group, in 62.5% of cases. Adverse effects were seen in 11 patients, including infection of the donor site (5 cases), keloid formation (3) and hypopigmentation (3). CONCLUSION Autoinoculation may be an effective therapeutic modality for cutaneous warts and two sessions may be required for optimum results.

Pseudoxanthoma elasticum and nephrocalcinosis: Incidental finding or an infrequent manifestation?

Pseudoxanthoma elasticum (PXE) is an inherited disorder characterized by generalized fragmentation and progressive calcification of elastic tissue. We report two sporadic cases of PXE, both of whom presented with asymptomatic yellowish papules over the flexural sites for cosmetic reasons. Histopathological findings on hematoxylin and eosin and Verhoeff-Van Gieson (VVG) staining were classical of PXE. In addition to this, renal calcification was documented on plain radiography of kidneys, ureters, and bladder (KUB) in both the cases. Paucity of literature describing the association of nephrocalcinosis with PXE prompted the present report.

Blaschko-linear syringocystadenoma papilliferum: A peculiar presentation

497 Indian Dermatology Online Journal | Volume 8 | Issue 6 | November‐December 2017 Clin 1992;42:116‐25. 9. Arifin MZ, Yudoyono F, Dahlan RH, Hernowo BS, Sutiono AB, Faried A. A rare giant scalp dermatofibrosarcoma protuberans. Surg Neurol Int 2014;5:45. 10. Liansheng L, Xialiang L, Yaodong Z, Yajun X, Meiqing L. Report of two cases of recurrent scalp dermatofibrosarcoma protuberans and literature review. Indian J Dermatol 2014;59:602‐5 11. Nouri K, Lodha R, Jimenez G, Robins P. Mohs micrographic surgery for Dermatofibrosarcoma protuberans: University of Miami and NYU experience. Dermatol Surg 2002;28:1060‐4.

Secondary syphilid developing over healed lesions of varicella: Wolf's isotopic response?

Isotopic response is a distinctive phenomenon in which a new skin disorder occurs at the site of another, unrelated, and already healed skin disease. Most of the cases documented in the literature were associated with herpes zoster as primary disease while the list of “second” diseases is quite long. We report here a hitherto unreported occurrence of isotopic response in which secondary syphilis occurred on the healed lesions of varicella.

Colocalization of lichen planus hypertrophicus and epidermal inclusion cyst: An incident unreported hitherto

Colocalization of diseases in dermatology has always remained elusive and a puzzle, difficult to unscramble. Co-localization of two rare and disparate dermatoses has been reported on several occasions. Lichen planus (LP) has been described to colocalize with several dermatoses. We report here a case of LP hypertrophicus co-localizing with epidermoid cysts on the scrotum of a 35-year-old man for the unusual site and association.