Tobias Knoch
Heidelberg University
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Publication
Featured researches published by Tobias Knoch.
Cell | 2008
Suchit Jhunjhunwala; Menno C. van Zelm; Mandy M. Peak; Steve Cutchin; Roy Riblet; Jacques J.M. van Dongen; Frank Grosveld; Tobias Knoch; Cornelis Murre
The immunoglobulin heavy-chain (Igh) locus is organized into distinct regions that contain multiple variable (V(H)), diversity (D(H)), joining (J(H)) and constant (C(H)) coding elements. How the Igh locus is structured in 3D space is unknown. To probe the topography of the Igh locus, spatial distance distributions were determined between 12 genomic markers that span the entire Igh locus. Comparison of the distance distributions to computer simulations of alternative chromatin arrangements predicted that the Igh locus is organized into compartments containing clusters of loops separated by linkers. Trilateration and triple-point angle measurements indicated the mean relative 3D positions of the V(H), D(H), J(H), and C(H) elements, showed compartmentalization and striking conformational changes involving V(H) and D(H)-J(H) elements during early B cell development. In pro-B cells, the entire repertoire of V(H) regions (2 Mbp) appeared to have merged and juxtaposed to the D(H) elements, mechanistically permitting long-range genomic interactions to occur with relatively high frequency.
Future Generation Computer Systems | 2009
Dagmar Krefting; Julian Bart; Kamen Beronov; Olga Dzhimova; Jürgen Falkner; Michael Hartung; Andreas Hoheisel; Tobias Knoch; Thomas Lingner; Yassene Mohammed; Kathrin Peter; Erhard Rahm; Ulrich Sax; Dietmar Sommerfeld; Thomas Steinke; Thomas Tolxdorff; Michal Vossberg; Fred Viezens; Anette Weisbecker
Differentiation | 2008
Joachim Rauch; Tobias Knoch; Irina Solovei; Kathrin Teller; Stefan Stein; Karin Buiting; Bernhard Horsthemke; Jörg Langowski; Thomas Cremer; Michael Hausmann; Christoph Cremer
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | 2010
Frank Dickmann; Maximilian Brodhun; Jürgen Falkner; Tobias Knoch; Ulrich Sax
BMC Medical Genetics | 2007
Ulrich Sax; Tobias Knoch; Sebastian Semler; Anette Weisbecker; Jürgen Falkner; Fred Viezens; Yassene Mohammed; Michael Hartung; Julian Bart; Dagmar Krefting
Archive | 2016
Frank Grosveld; Tobias Knoch
Archive | 2009
Frank Dickmann; Fred Viezens; Ulrich Sax; Mathias Kaspar; Benjamin Löhnhardt; Nick Kepper; Frank Hertel; Michael Lesnussa; Yassene Mohammed; Andreas Thiel; Thomas Steinke; Johannes Bernarding; Dagmar Krefting; Tobias Knoch
Archive | 2011
Tobias Knoch; Anis Abuseiris; Michael Lesnussa; Nick Kepper; Rob de Graaf; Frank Grosveld
Archive | 2016
Tobias Knoch; Malte Wachsmuth
Archive | 2016
Tobias Knoch; Malte Wachsmuth; Nick Kepper; Michael Lesnussa; Anis Abuseiris; Ali Imam; Petros Kolovos; Jessica Zuin; Christel Kockx; Rutger W. W. Brouwer; Harmen J.G. van de Werken; Wilfred van IJcken; Kerstin S. Wendt; Frank Grosveld
