Todd Castleberry

Pilot study: an acute bout of high intensity interval exercise increases 12.5 h GH secretion.

The purpose of this study was to test the hypothesis that high‐intensity interval exercise (HIE) significantly increases growth hormone (GH) secretion to a greater extent than moderate‐intensity continuous exercise (MOD) in young women. Five young, sedentary women (mean ± SD; age: 22.6±1.3 years; BMI: 27.4±3.1 kg/m2) were tested during the early follicular phase of their menstrual cycle on three occasions. For each visit, participants reported to the laboratory at 1700 h, exercised from 1730–1800 h, and remained in the laboratory until 0700 h the following morning. The exercise component consisted of either 30‐min of moderate‐intensity continuous cycling at 50% of measured peak power (MOD), four 30‐s “all‐out” sprints with 4.5 min of active recovery (HIE), or a time‐matched sedentary control using a randomized, cross‐over design. The overnight GH secretory profile of each trial was determined from 10‐min sampling of venous blood from 1730–0600 h, using deconvolution analysis. Deconvolution GH parameters were log transformed prior to statistical analyses. Calculated GH AUC (0–120 min) was significantly greater in HIE than CON (P = 0.04), but HIE was not different from MOD. Total GH secretory rate (ng/mL/12.5 h) was significantly greater in the HIE than the CON (P = 0.05), but MOD was not different from CON or HIE. Nocturnal GH secretion (ng/mL/7.5 h) was not different between the three trials. For these women, in this pilot study, a single bout of HIE was sufficient to increase 12.5 h pulsatile GH secretion. It remains to be determined if regular HIE may contribute to increased daily GH secretion.

The change in metabolic heat production is a primary mediator of heat acclimation in adults

PURPOSE This study examined whether heat acclimation (HA) results in either predominate improvements in heat dissipation or reduced endogenous heat production via individual components of the human heat balance equation. METHODS Twelve healthy inactive subjects (5 females, mean ± SD): age 28 ± 6y, 77.9 ± 2kg), completed a 10-day HA (42°C, 28% RH) hyperthermia clamp (90min/day exercise, ∆1.5°C in rectal temperature (Tre)) and control workload matched (CON: 23°C, 42% RH) protocols in a counterbalanced design separated by at least 2 mo. Pre-and post-HA were matched for external work rate (EXWR; day 1 and day 10 first 30min at 118 ± 29W, last 60min at 11 ± 5W); and metabolic heat production (Hprod; day 1 and day 9, first 30min at 296 ± 26Wm-2, last 60min 187 ± 33Wm-2). RESULTS When Pre- and post- HA was matched for Hprod, there was no difference during the first 30 or last 60min of exercise for metabolic energy expenditure (MEE 363 ± 70/ 195 ± 32Wm-2), Hprod (296 ± 67/ 187 ± 33Wm-2) or Tre (∆2.1 ± 0.5°C). When pre- and post-HA was EXWR equivalent, HA significantly attenuated MEE during the first 30 and last 60min (303 ± 49/ 174 ± 35Wm-2), Hprod (241 ± 44/ 168 ± 33, W·m-2), and ∆Tre (∆1.3 ± 0.4°C) (each P < 0.0001). When ∆Tre, ∆Tsk, ∆Tb were each normalized per 100W Hprod, no differences were found for any pre-to post-HA comparison. Heat loss required (Ereq) to maintain steady state internal temperature (Ereq = 220 ± 32Wm-2), maximal capacity of the climate for evaporative heat loss (Emax = 266 ± 56Wm-2), evaporative heat loss from skin (Esk = 207 ± 38Wm-2) or skin wettedness (Ereq/Emax = 0.88 ± 0.23Wm-2) were not different among each condition during the last 60min. CONCLUSION The mechanisms that underlie heat acclimation are not wholly attributed to heat dissipation enhancements per se, but are significantly influenced by metabolic heat production alterations under uncompensable heat stress environments.

Cardiorespiratory Responses During Aquatic Treadmill Exercise and Land Treadmill Exercise in Adults with Diabetes: 752 Board #68 June 1, 3: 30 PM - 5: 00 PM.

The purpose of this study was to compare the effect of aquatic treadmill (ATM) exercise to land treadmill (LTM) exercise in adults with type 2 diabetes. Five participants with type 2 diabetes (T2D group; 4 females, 1 male; age = 51±6 years; height = 170±7 cm; weight = 96±24 kg; body fat = 31.6±2.2%) and five participants without type 2 diabetes (control group; 4 females, 1 male; age = 51±6 years; height = 170±6 cm; weight = 71±15 kg; body fat = 26.8±4.6%) completed the study. Protocols for both ATM exercise and LTM exercise began at 2 mph with 0% grade and increased by 1 mph after 5 minutes at each stage. Termination occurred after participants completed the protocol or reached 85% of heart rate reserve. Heart rate, absolute and relative VO2, and systolic and diastolic blood pressure were measured at rest and during steady-state exercise at each intensity. Mean arterial pressure (MAP) was calculated. A 2 x 2 x 3 Mixed Factorial ANOVA and Bonferroni post hoc test with a significance level of .0125 were used. There was a significant difference (p<.0125) in all measures with an increase in intensity for each mode of exercise. Heart rate response was significantly different at 2 mph and 4 mph between LTM exercise and ATM exercise for those with type 2 diabetes (LTM @ 2 mph: 101±12 bpm vs. ATM @ 2 mph: 92±8 bpm, p<.0125; LTM @ 4 mph: 140±18 bpm vs. ATM @ 4 mph: 123±12 bpm, p<.0125) and those without type 2 diabetes (LTM @ 2 mph: 91±10 bpm vs. ATM @ 2 mph: 82±10 bpm, p<.0125; LTM @ 4 mph: 125±15 bpm vs. ATM @ 4 mph: 113±12 bpm, p<.0125). There was a significant difference between the relative VO2 of the two groups at 4 mph while performing the land treadmill exercise (T2D: 14.1±1.4 ml/kg/min vs. control: 18.4±1.6 ml/kg/min, p<.0125). There was no difference in absolute VO2 between participant groups or modes of exercise. Those with type 2 diabetes had an increased MAP versus those without type 2 diabetes while performing the land treadmill exercise at 2 mph (T2D: 93±3 mmHg vs. control: 81±5 mmHg, p<.0125). Although there is some evidence for the varying effects of ATM and LTM exercise when comparing those with type 2 diabetes and those without type 2 diabetes, heart rate, VO2, and MAP respond similarly in both groups during ATM and LTM exercise at most treadmill speeds.