Tohru Tani

A mechanism for shock following stomach rupture in the newborn

Abstract Background: Stomach rupture often leads to shock and death within a short period, but the mechanism for this is not well‐known. Shock may be due, in part, to endotoxin translocation and endotoxemia.

The new therapy for septic multiple organs failure.

Forty-two patients with severe infection were treated with direct hemoperfusion (DHP) using polymyxin B immobilized fiber column (PMX) . Thirty-eights out of 42 suffered MOF. DHP was performed for 2 hours via femoral vein with double lumen catheter.Blood endotoxin level was high in 35 patients, and in these patients were cured 19/35 (54%), but 3/8 (38%) in the patients with normal endotoxin level. The patients with pathogenic bacteria were cured 20/31 (61%), but patients without cultured bacteria showed significantly lower survival rate (23%) .Blood endotoxin levels significantly decreased between the inlet and the outlet of column.Cardiovascular parameter (blood pressure, C.I SVR, VO2I) and body temperature were significantly improved after DHP in the patients with abnormal values.PMX therapy on the MOF patients with systemic inflammatory response syndrome due to infection was demonstrated to be effective.