Toju Hata

Structure of prumycin

The antibiotic prumycin has been identified as 4-D-alanylamino-2-amino-2,4-dideoxy-L-arabinose (1). 1H and 13C N.m.r. data for prumycin and related compounds, particularly the methyl glycoside of O-acetyl-NN′-bisbenzyl-oxycarbonylprumycin (6β) and NN′-diacetylprumycin (3), were major factors in establishing the structure. The absolute configuration was derived by comparing the optical rotation of prumycin with those of other L-arabinose derivatives.

Pyrindicin, a New Alkaloid from a Streptomyces Strain

In the course of our examination for the alkaloid productivities of Streptomyces strains, Streptomyces sp. NA–15 was found to produce a new alkaloid, pyrindicin, in the culture medium. The strain NA–15 was found to be a variant of Streptomyces griseoflavus and was designated as S. griseoflavus var. pyr indie us nov. var.After the culture conditions for pyrindicin production were studied, pyrindicin was obtained as its hydrochloride (mp 145°C, decomp.) from the cultured broth. The compound was shown to possess weak antimicrobial and several pharmacological activities. The LD50 of the hydrochloride (ip, in mice) was 87 mg/kg.