Tokio Onodera

Antitumor effect of methionine-depleting total parenteral nutrition with doxorubicin administration on yoshida sarcoma-bearing rats

Methionine‐depleting total parenteral nutrition (methionine‐depleting TPN), which infuses an amino acid solution devoid of L‐methionine and L‐cysteine as the sole protein source, showed enhancement of the effect of several anti‐cancer agents. In this study, the combined effect of the methionine‐depleting TPN with the administration of doxorubicin was examined in Yoshida sarcoma (YS)‐bearing rats with regard to effects on the primary tumor growth, the extension of metastasis, and the host animals life span.

Anti-tumor effect of L-methionine-deprived total parenteral nutrition with 5-fluorouracil administration on Yoshida sarcoma-bearing rats.

L-methionine-deprived total parenteral nutrition (methionine-deprived TPN), infusing amino acid solution devoid of L-methionine and L-cysteine by the method of TPN as an only protein source, showed enhancement of the effect of several anti-cancer agents. In this study the combined effect of the methionine-deprived TPN with administration of 5-fluorouracil (5-FU) was examined in Yoshida Sarcoma (YS)-bearing rats, from aspects of effects on the tumor metastasis and the host animals life span, in the following four groups treated with: methionine-deprived TPN with administration of 5-FU, methionine-deprived TPN without administration of 5-FU, L-methionine-contained TPN plus 5-FU, and L-methionine-contained TPN without 5-FU. In the first experiment, TPN was continued for 8 days in the four groups, and the anti-cancer effect of methionine-deprived TPN and administration of 5-FU based on both the growth of the primary tumor at the implanted site and the tumor metastasis was studied from the view point of pathologic findings of animals killed immediately after these treatments. In experiment 2 the survival period was examined after these treatments for 10 days with subsequent oral feeding until death. The results were as follows: proliferation of YS, transplanted subcutaneously, was markedly suppressed; particularly hematogenous metastasis, characteristic in YS, was prominently blunted then obtained an apparent longer survival period in rats treated with the methionine-deprived TPN with administration of 5-FU.

Intraoperative radiation therapy for pancreatic carcinoma

SummaryNinety patients with carcinoma of the pancreas treated between 1976 and 1990 were reviewed retrospectively. Intraoperative radiation therapy (IORT) in combination with external beam radiation therapy (EBRT) for localized but unresectable tumors (n = 29) prolonged survival significantly more than IORT alone (n = 16) (p < 0.01); it seems EBRT enhanced or contributed to the better results obtained with IORT plus EBRT. Moreover, IORT, alone or in combination, relieved pain. Adjuvant IORT for residual tumors (n = 20) might not effectively prolong survival, because the difference in survival rate between noncurative resection plus IORT and nonresection plus IORT in combination with EBRT was not significant. Curative tumor resection of stage III disease in combination with IORT (n = 9) resulted in significantly longer survival as compared with curative tumor resection alone (n = 8) (p < 0.05). It may be advisable to administer IORT in combination with EBRT to patients with advanced pancreatic carcinoma, avoiding aggressive tumor resection, when curative tumor resection cannot be performed.

Intraoperative Radiation Therapy in Combination with Conformation Radiation Therapy for Localized Unresectable Pancreatic Carcinoma. An Analysis of 13 Patients Survived for More than One Year.

遠隔転移のない切除不能の進行膵癌46例に対し術中照射療法を行い, 30例に主に原体照射法による術後外部照射を追加した.外部照射併用30例中13例が1年以上生存 (最長生存20か月, 2例), 1年生存率は46.4% (median survival 11か月) であった.これに対し術中照射単独16例には1年生存はなくmedian survivalは6.2か月であった.両群間で生存率に有意差を認めた (p<0.01).1年以上生存した7例の剖検所見の特徴は, 肉眼的には腫瘍の著明な縮小であり, 組織学的には腫瘍の硝子化と線維化およびその内部に存在する変性や壊死に陥った癌細胞であったが, 腫瘍は周辺から後腹膜組織, 周囲臓器へとscirrhousに浸潤する傾向にあった.また術中照射は治療前に癖痛を訴えていた28例の内16例 (57%) に落痛の消失をもたらし, 1年以上の延命とquality of lifeの向上に寄与した.