Tokumaru Y
Chiba University
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Tokumaru Y.
Journal of Neurology, Neurosurgery, and Psychiatry | 2005
Shoichi Ito; Satoshi Kuwabara; Toshio Fukutake; Tokumaru Y; Takamichi Hattori
Background: Juvenile muscular atrophy of the distal upper extremity (Hirayama disease) is characterised by anterior horn cell loss in the lower cervical cord, presumably caused by anterior displacement of the dural sac during neck flexion. A recent report suggests that atopy and IgE may contribute to anterior horn damage. Objective: To investigate whether IgE is a contributing factor in Hirayama disease. Methods: Serum total IgE and allergen specific IgE were examined in 20 consecutive patients, and their correlations with clinical profiles investigated. Results: Past or present history of allergy/atopy was found in only four patients (20%), but serum IgE was raised in 14 (70%). Patients with hyperIgEaemia had more severe clinical disabilities than those without (p = 0.01). In patients whose history of Hirayama disease was less than five years, serum total IgE was higher than in those with the disease for five years or more (p = 0.05). Conclusions: The results suggest that hyperIgEaemia is often associated with Hirayama disease and can facilitate its pathophysiology, particularly in the early phases of the disease. HyperIgEaemia does not appear to involve the anterior horn cells primarily.
Brain | 1996
Toshio Fukutake; K. Kita; Ryuji Sakakibara; K. Takagi; Tokumaru Y; Shigeyuki Kojima; Takamichi Hattori; Hirayama K
Rinshō shinkeigaku Clinical neurology | 1994
Yoshiyama Y; Tokumaru Y; Katayama K; Mochizuki M; Hirayama K
Rinshō shinkeigaku Clinical neurology | 1992
Nagumo K; Arai K; Satoshi Kuwabara; Tokumaru Y; Hirayama K
Rinshō shinkeigaku Clinical neurology | 1984
Kita K; Hirayama K; Takamichi Hattori; Tokumaru Y
Rinshō shinkeigaku Clinical neurology | 1995
Kamitsukasa I; Yamada T; Tokumaru Y; Hirayama K
Rinshō shinkeigaku Clinical neurology | 1994
Satoshi Kuwabara; Nakajima M; Tokumaru Y; Hirayama K
Rinshō shinkeigaku Clinical neurology | 1990
Tokumaru Y; Hirayama K; Kita K; Mitsuru Kawamura; Katayama K
Rinshō shinkeigaku Clinical neurology | 1997
Kijima M; Kita K; Tokumaru Y; Hirayama K
Rinshō shinkeigaku Clinical neurology | 1995
Osumi E; Imai T; Tokumaru Y; Kita K; Hirayama K