Tokuro Nagayama

Clinical Studies of Patients with Rubella Syndrome Occurring in a High Incidence in the Ryukyu Islands in 1965: On the Diagnostic Significance of Clinical Manifestations

The 620 cases with a history of maternal rubella and/or with one or more of cataract, CHD and deafness born in the Ryukyu Islands in 1965 were subjected to clinical studies and 360 cases were diagnosed as rubella syndrome. Rubella retinopathy makes a reliable diagnostic basis for rubella syndrome. As for the typical combination of clinical manifestations, the cases with cataract have CHD, deafness and retinopathy; the cases with CHD not accompanied by cataract have deafness and retinopathy; and the cases with deafness not accompanied by cataract and CHD either have or have not retinopathy. The cases with cataract alone or with CHD can extremely rarely be denned as having rubella syndrome. There existed the close relationship between the combination of clinical manifestations and the time of maternal rubella infection.

Effects of mucin upon growth of low birth-weight infants and their intestinal microflora.

Purified hog gastric mucin was administered to low birth‐weight infants at a dose of 7 mg per kg body weight per day and the following results were obtained:

Progressive Muscular Dystrophy in Infancy

Clinical features of 11 cases of muscular dystrophy in infancy were discussed. From the detailed symptomatological analysis of the 11 patients we reported here, we found two subgroups of infantile muscular dystrophy. There were 6 cases of congenital cerebro‐muscular dystrophy (Fukuyama) and 5 cases characterized by comparatively late onset, no sexual preference, proximally dominant muscle wasting, infrequence of associated joint contractures, normal facial muscle and no mental deficiency. The characteristics of this latter group in infantile muscular dystrophy are similar to those of limb‐girdle muscular dystrophy. It is suggested that some of the patients with limb‐girdle type of muscular dystrophy may have its onset in infancy.

The Clinical Pattern & The Causative Factors of Late Edema Observed in Low Birth Weight Infants.

Edema may sometimes be observed on the pudendum, the dorsum ephipii, the back of leg and the eye l ideven on the hypogastric region in more severe casesin low birth weight infants when they are about onemonth old. In contrast to early edema occurring shortly after birth, it is called late edema. ( 1 ) What is responsible for edema is not yet established. We wish to investigate the clinical patterns and the causative factors for the findings so far obtained from 55 cases at our ward since 1962.