Tokuya Tomioka
Fukuoka Dental College
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Publication
Featured researches published by Tokuya Tomioka.
International Journal of Oral and Maxillofacial Surgery | 1999
Kentaro Matsumoto; Yasuro Ninomiya; Masaki Inoue; Tokuya Tomioka
A semi-synthetic analogue of fumagillin, TNP-470, has been shown to be a potent angiogenesis inhibitor. In this study, we evaluated the anti-tumor efficacy of TNP-470 on rabbits bearing VX2 carcinoma of the tongue, by comparison of topical, intra-tumor (i.t.) injection with systemic, intra-venous (i.v.) administration. The i.t. injection of the angiogenesis inhibitor produced much stronger anti-tumor effects, and almost complete tumor regression was achieved at doses of 10 mg/kg or 20 mg/kg. TNP-470 injected intra-tumorally significantly reduced expression of proliferating cell nuclear antigen (PCNA) and microvessel density in the VX2 carcinoma of the tongue. TNP-470 also halted the tumor-associated neovascularization in the rabbit cornea assay. These data suggest that i.t. injection of TNP-470 effectively inhibits tumor angiogenesis and disrupts microvasculature development, which may suppress tumor growth. In conclusion, the i.t. injection of TNP-470 provided remarkable anti-tumor effects on the VX2 carcinoma of the tongue and is expected to have promising therapeutic uses for oral cancer.
Japanese Journal of Oral & Maxillofacial Surgery | 1989
Syunji Kusumoto; Takuya Kamogawa; Tomokazu Miyamoto; Fumio Goto; Hidetoshi Wakae; Tokuya Tomioka; Katsya Kitamura
The tumor mass developed in the 45 lingual gingival region of a 56-year-old female, which was clinically and histopathologically diagnosed as an epulis osteoplastica, was examined with the transmission electron microscope. 1. In histopathological findings. The tumor was covered with laminated flat epithelium, which was severely filled with the connective tissue. Bone tissues were observed between these fibers. 2. In transmission electron microscopic findings. 1) The tissue was recognized to fully contain mature collagen fibers. Partially Osteoblast, Osteoclast and bone matrix can be seen in them. 2) These bone matrix formations suggested the calcification of a typical needle crystal which ran along the crosstriation structure of collagen fibers.
The Kurume Medical Journal | 1990
Tamaka Okina; Kazuhisa Esaki; Asako Nagata; Jingo Kusukawa; Chihiro Koga; Yumiko Nagao; Mutsumi Uchiyama; Michio Ohgusu; Tadamitsu Kameyama; Hidetoshi Wakae; Fumio Goto; Tokuya Tomioka
Journal of Japan Society for Oral Tumors | 1998
Kunio Ikemura; Shigetaka Yanagisawa; Satoru Ozeki; Masanori Shinohara; Eiro Kubota; Masatsugu Shimizu; Sukehide Yamashita; Masuichiro Oka; Jinichi Fukuda; Minoru Kajiyama; Masamichi Oishi; Kanemitsu Shirasuna; Tadamitsu Kameyama; Tokuya Tomioka; Takeshi Honda; Haruhiko Miyako; Takeshi Katsuki; Akio Mizuno; Tsugio Inokuchi; Akira Taen; Ryosuke Shiba; Kazumasa Sugihara; Hajime Sunakawa; Shigenobu Kanda; Akira Tateishi; Hideo Kurokawa; Jingo Kusukawa; Iwao Hara; Yoshihide Fujimura; Kazuo Sano
Japanese Journal of Oral & Maxillofacial Surgery | 1977
Toshihiko Yamanaka; Yoshio Sawakuma; Hidetoshi Wakae; Shoji Toyoshima; Tokuya Tomioka
International Journal of Oral and Maxillofacial Surgery | 1997
Yasuro Ninomiya; Kentaro Matsumoto; H. Wakae; Tokuya Tomioka
Japanese Journal of Oral & Maxillofacial Surgery | 1977
Akihiro Sakamoto; Masakuni Ishibashi; Hidetoshi Wakae; Shoji Toyoshima; Tokuya Tomioka
Journal of Japan Society for Oral Tumors | 1998
Iwao Hara; Kentaro Matumoto; Hidetoshi Wakae; Yasuro Ninomiya; Tokuya Tomioka; Kunihisa Taniguchi; Katsuya Kitamura
Journal of Japan Society for Oral Tumors | 1997
Kentaro Matsumoto; Kazuo Higaki; Kunihisa Taniguchi; Kazuhiko Okamura; Mamoru Tanaka; Hiroyuki Shibata; Hidetoshi Wakae; Tokuya Tomioka
International Journal of Oral and Maxillofacial Surgery | 1997
I. Hara; K. Matumoto; H. Wakae; Yasuro Ninomiya; Tokuya Tomioka