Tomás Seosamh Harrington

Inkjet printing for pharmaceutics – A review of research and manufacturing

Global regulatory, manufacturing and consumer trends are driving a need for change in current pharmaceutical sector business models, with a specific focus on the inherently expensive research costs, high-risk capital-intensive scale-up and the traditional centralised batch manufacturing paradigm. New technologies, such as inkjet printing, are being explored to radically transform pharmaceutical production processing and the end-to-end supply chain. This review provides a brief summary of inkjet printing technologies and their current applications in manufacturing before examining the business context driving the exploration of inkjet printing in the pharmaceutical sector. We then examine the trends reported in the literature for pharmaceutical printing, followed by the scientific considerations and challenges facing the adoption of this technology. We demonstrate that research activities are highly diverse, targeting a broad range of pharmaceutical types and printing systems. To mitigate this complexity we show that by categorising findings in terms of targeted business models and Active Pharmaceutical Ingredient (API) chemistry we have a more coherent approach to comparing research findings and can drive efficient translation of a chosen drug to inkjet manufacturing.

Identifying design criteria for urban system ‘last-mile’ solutions – a multi-stakeholder perspective

Abstract This study presents a novel approach to design and evaluate ‘last-mile’ solutions – encompassing the social and economic perspectives of key stakeholders. While urban system initiatives have been implemented in practice, theoretical gaps remain at the operational design level. A theoretical framework is developed, based on design criteria identified from a critical synthesis of supply chain and operations management literature, and ‘operationalised’ using an in-depth case study demonstrating implementation of a Consumer Choice Portal-Package Consolidation Centre solution, within a densely populated urban geography. Findings suggest that there is a need to re-define the role of institutional actors beyond that of the traditional governance task, to one of being able to facilitate performance outcomes. Similarly, industrial efficiency dimensions need to be reorientated to include consumer participation, social considerations and multi-stakeholder service outcomes. Finally, implications for operations theory and practising managers in city logistics are highlighted, with suggested directions for future research.

Characteristics of redistributed manufacturing systems: a comparative study of emerging industry supply networks

This paper explores the characteristics of redistributed manufacturing systems within the context of emerging industry supply networks (EI SNs), with a particular focus on their structure, operations and reconfiguration dynamics. A number of factors have resulted in the redistribution of manufacturing. Within Emerging Industries, advances in process and information technologies, have changed the physical and information characteristics of components and products, and the viable production economies of scale. Further, the emergence of new specialised companies fulfilling key research, production or service roles have changed industry structure and operations, and the conventional model of value creation. Six industrial systems are examined using an Industrial System mapping methodology providing a basis for cross-case analysis, selected on the basis of representing alternative and novel evolution paths that may provide insights into the characteristics of EI SNs within a redistributed manufacturing context. Cross-case analysis suggests several generic aspects to EI SNs, including the blurring of traditional industry boundaries and the critical requirement to manage uncertainty. Alternative forms of EI SNs are observed supporting particular EI evolution paths. Further, more adaptive SNs support increased product variety, with lower inventory models enabled by enhanced production and distribution flexibility, often located closer to demand.

Reconfiguring global pharmaceutical value networks through targeted technology interventions

Targeting a series of advanced manufacturing technology (AMT) ‘interventions’ provides the potential for significant step changes across the pharmaceutical value chain, from early stage ‘system discovery’ and clinical trials, through to novel service supply models. This research explores future value network configurations which, when aligned with disruptive shifts in technology (process and digital), may enable alternative routes to medicines production and the delivery of additional value to ‘end-users’, i.e. patients and health care providers. We draw on a categorisation of AMTs that may enable a shift from the traditional ‘batch’ and centralised manufacturing paradigm of ‘make-to-stock’, towards more re-distributed ‘continuous’ manufacturing and ‘make-to-order’ models. Despite reported benefits in the academic literature (e.g. reduced footprints, improved quality, enhanced flexibility and inventory savings), current adoption rates of continuous technologies in this sector remain low (c. 5%). This paper presents new data sources, in our study of AMT adoption in a global pharmaceutical context – assessing the barriers to implementation, and the pathways to delivering future continuous manufacturing scenarios. Our findings capture the high level of disparity in viewpoints, highlighting the uncertainties and transformational challenges ahead – in terms of opportunity areas, technological readiness and a future vision for the sector, as a whole.

Designing a ‘concept of operations’ architecture for next-generation multi-organisational service networks

Abstract Networked service organisations are increasingly adopting a ‘smarter networking’ philosophy in their design of more agile and customer-focused supply models. Changing consumer behaviours and the emergence of transformative technologies—industry 4.0, artificial intelligence, big data analytics, the Internet of Things—are driving a series of innovations, in terms of ‘products’ and business models, with major implications for the industrial enterprise, in their design of more ‘digitalised’ supply chains. For B2B systems, emerging ‘product-service’ offerings are requiring greater visibility, alignment and integration across an increasingly complex network of multiple partners and collaborators, in order to deliver a better service and customer ‘experience’. To support the design and operation of these multi-organisational service networks, we outline a concept of operations architecture here, underpinned by the literature and network theory, and demonstrate application using a series of exemplar case studies. Focusing on relational elements and the processes key to network integration within service supply networks, the cases inform a set of operating principles and protocols—applicable to all stakeholders ‘cooperating’, within a ‘shared’ environment. Equally critical is to understand how digital technologies may influence future operating philosophies. This article extends our theoretical understanding of network organisations, from a traditional ‘product’ perspective to that of ‘services’, and presents the case for developing a common, unified approach to designing diverse forms of multi-partner service networks.

Exploring Generalisations for Sustainability Assessment in Medicine Manufacturing Networks

Generalisations or ‘rules of thumb’ are widely used in industry to make initial assessments on the sustainability impacts of products. This paper re-examines the principles underpinning these generalisations in assessing the environmental impacts of medicine manufacturing network configurations. Each principle is illustrated through the application of selected methods, tools, and data using an exemplar case of a major non-proprietary analgesic. The findings identify the kind of generalised knowledge claims that are possible using alternative approaches, and which methodological issues may arise