Tomasz Tomaszewski

Association between clinical stage of oral cancer and expression of immunohistochemical markers

AIM The aim of this study is to demonstrate the possible correlation between the expression of examined protein markers - p53, EGFR, PCNA, p44/42 in the mass of the tumor and the clinical stage of disease. MATERIAL 48 patients of the Department and Clinic of Oral and Maxillofacial Surgery, Lublin diagnosed with oral cancer. The control group consisted of 10 patients diagnosed with leukoplakia lesions in the oral cavity. The methods: Immunohistochemical analysis using the detection system DAKO K5007 Cat - Dako REAL ™ Detection System, Peroxidase DAB +, Rabbit / Mouse. RESULTS Based upon the statistical results, significant correlation between p53 protein and tumor staging; however, a correlation between the level of expression of EGFR, p44/42, PCNA and staging was not likewise revealed. CONCLUSIONS Looking for oral squamous cell carcinoma markers remains an actual issue. Identification of specific markers of oral cancer could be used in screening the population, determining prognosis and response to treatment.

Severe herpes simplex oral mucositis in a patient with non-Hodgkin’s lymphoma after autologous stem cells transplantation – Case Report

The study presents the case of a 25-year-old patient with the diagnosis of diffuse large B cell lymphoma treated autologously with haematopoietic stem cells transplantation. During the period of aplasia after chemotherapy severe sore lips, mouth and esophagus herpes simplex mucositis developed and is successfully treated with foscarnet. The clinical course, localized causal and symptomatic treatment, along with the therapy imaging, are presented.

Epidemiological analysis of 22 patients with congenital bleeding diathesis hospitalized in the Department of Maxillofacial Surgery in Lublin, Poland, 2008–2013

Introduction. Haemophilia A and B are congenital bleeding disorders caused by coagulation factor VIII or IX deficiency. Haemophilia A and B occur in men, like all qualities dependent on genes linked to gender, whereas women are asymptomatic carriers of the gene. The most dangerous manifestations of severe haemophilia include spontaneous haemorrhages into the joints, muscles and body cavities, haematuria and potentially very dangerous intracranial haemorrhages are also quite frequent. The most common manifestations in the region of the maxillofacial skeleton and oral cavity are recurring bleedings from the nose and the gums after dental extractions, as well as extensive haemorrhages from wounds after surgical procedures. Objective. The aim of the study was the analysis of epidemiologic case records of 22 patients affected by various types of haemophilia, admitted to Maxillofacial Surgery Department at Medical University in Lublin, Poland, during 2008–2013. Results. The most numerous group constituted patients diagnosed with Haemophilia A, followed by patients with von Willebrand disease and Haemophilia B, aged 21–40 years. The main cause of hospital admission was the need to perform complex oral cavity sanation. The patients were treated with factor VIII or Factor IX, FEIBA or Heamate P, depending on the type and severity of bleeding diathesis.

Cervicofacial actinomycosis following jaw pathology – Case Reports

Cervicofacial actinomycosis is a specific, primarily chronic inflammatory process caused by Gram-positive anaerobic, microaerophilic Actinomyces bacteria. The infection usually results from the skin or mucosal lesions. The following paper reports two cases of Cervicofacial actinomycosis in patients admitted in 2014 to Maxillofacial Surgery Department in Lublin, Poland. Diagnosis of culture-positive actinomycosis was based on histopathology findings and the presence of actinomyces colonies. Cervicofacial actinomycosis requires surgical treatment, oral cavity sanation, and in the case of presenting actinomycosis abscesses formation, combined surgical incision and drainage. Long-term penicillin antibiotic therapy is necessary.

The cooperation between orthodontists and surgeons in treating facial skeletal deformities

Abstract Face skeletal deformities have been confusing both doctors and patients for ages. The harmony of the face exerts huge influence not only on one’s psyche but also the behavior and the individual’s social and professional status. In this study we present a procedure of treating skeletal malocclusion. It was performed using various orthodontic methods, like the alteration of the growth of jaws and camouflage applied in appropriate age groups. We paid special attention to the close cooperation between the orthodontist and the surgeon, which hugely facilitates curing the most complex, multi-dimensional deformities. In this study, we present our own materials concerning the effects of cooperation between two departments of Medical University of Lublin, namely the Chair and Clinic of Maxillofacial Surgery and Department of Jaw Orthopedics.