Tomio Ichikawa
Nagoya University of Arts and Sciences
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Publication
Featured researches published by Tomio Ichikawa.
International Journal of Cancer | 2005
Yoshihisa Yano; Haruna Satoh; Keiko Fukumoto; Itsumaro Kumadaki; Tomio Ichikawa; Kazuhiko Yamada; Kiyokazu Hagiwara; Tomohiro Yano
Tocotrienols are one of the most potent anticancer agents of all natural compounds and the anticancer property may be related to the inactivation of Ras family molecules. The anticancer potential of tocotrienols, however, is weakened due to its short elimination half life in vivo. To overcome the disadvantage and reinforce the anticancer activity in tocotrienols, we synthesized a redox‐silent analogue of α‐tocotrienol (T3), 6‐O‐carboxypropyl‐α‐tocotrienol (T3E). We estimated the possibility of T3E as a new anticancer agent against lung adenocarcinoma showing poor prognosis based on the mutation of ras gene. T3E showed cytotoxicity against A549 cells, a human lung adenocarcinoma cell line with a ras gene mutation, in a dose‐dependent manner (0–40 μM), whereas T3 and a redox‐silent analogue of α‐tocopherol (T), 6‐O‐carboxypropyl‐α‐tocopherol (TE), showed much less cytotoxicity in cells within 40 μM. T3E cytotoxicity was based on the accumulation of cells in the G1‐phase of the cell‐cycle and the subsequent induction of apoptosis. Similar to this event, 24‐hr treatment of A549 cells with 40 μM T3E caused the inhibition of Ras farnesylation, and a marked decrease in the levels of cyclin D required for G1/S progression in the cell‐cycle and Bcl‐xL, a key anti‐apoptotic molecule. Moreover, the T3E‐dependent inhibition of RhoA geranyl‐geranylation is an inducing factor for the occurrence of apoptosis in A549 cells. Our results suggest that T3E suppresses Ras and RhoA prenylation, leading to negative growth control against A549 cells. In conclusion, a redox‐silent analogue of T3, T3E may be a new candidate as an anticancer agent against lung adenocarcinoma showing poor prognosis based on the mutation of ras genes.
Bioscience, Biotechnology, and Biochemistry | 2010
Saiko Ikeda; Tomono Uchida; Tomio Ichikawa; Takashi Watanabe; Yukiko Uekaji; Daisuke Nakata; Keiji Terao; Tomohiro Yano
To determine the bioavailability of tocotrienol complex with γ-cyclodextrin, the effects of tocotrienol/γ-cyclodextrin complex on tocotrienol concentration in rat plasma and tissues were studied. Rats were administered by oral gavage an emulsion containing tocotrienol, tocotrienol with γ-cyclodextrin, or tocotrienol/γ-cyclodextrin complex. At 3 h after administration, the plasma γ-tocotrienol concentration of the rats administered tocotrienol/γ-cyclodextrin complex was higher than that of the rats administered tocotrienol and γ-cyclodextrin. In order to determine the effect of complexation on tocotrienol absorption, rats were injected with Triton WR1339, which prevents the catabolism of triacylglycerol-rich lipoprotein by lipoprotein lipase, and then administered by oral gavage an emulsion containing tocotrienol, tocotrienol with γ-cyclodextrin, or tocotrienol/γ-cyclodextrin complex. The plasma γ-tocotrienol concentration of the Triton-treated rats administered tocotrienol/γ-cyclodextrin complex was higher than that of the other Triton-treated rats. These results suggest that complexation of tocotrienol with γ-cyclodextrin elevates plasma and tissue tocotrienol concentrations by enhancing intestinal absorption.
Lipids | 2007
Chisato Abe; Tomono Uchida; Moeka Ohta; Tomio Ichikawa; Kanae Yamashita; Saiko Ikeda
Journal of Nutrition | 2007
Chisato Abe; Saiko Ikeda; Tomono Uchida; Kanae Yamashita; Tomio Ichikawa
Lipids | 2012
Tomono Uchida; Chisato Abe; Saki Nomura; Tomio Ichikawa; Saiko Ikeda
Journal of Nutritional Science and Vitaminology | 2011
Tomono Uchida; Saki Nomura; Tomio Ichikawa; Chisato Abe; Saiko Ikeda
Journal of Nutritional Science and Vitaminology | 2007
Tomono Uchida; Tomio Ichikawa; Chisato Abe; Kanae Yamashita; Saiko Ikeda
Journal of Nutritional Science and Vitaminology | 2007
Saiko Ikeda; Chisato Abe; Tomono Uchida; Tomio Ichikawa; Fumihiko Horio; Kanae Yamashita
Archive | 1989
Tomio Ichikawa; Kiyokazu Hagiwara
Abstracts of Annual Congress of The Japan Society of Home Economics 58th Annual Congress of The Japan Society of Home Economics | 2006
Chisato Abe; Saiko Ikeda; Masahiko Atobe; Kanae Yamashita; Tomio Ichikawa