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Tomio Ogasawara

Kyushu University

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Journal of Molecular Catalysis B-enzymatic | 2000

Xanthone derivatives as inhibitors for monoamine oxidase

Nobuko Ohishi; Takehiko Suzuki; Tomio Ogasawara; Kunio Yagi

Abstract Various xanthone derivatives were tested for in vitro inhibition of monoamine oxidase (MAO) in the mitochondrial fraction from rat brain and mouse liver. 1,6-Dihydroxyxanthone and 1,3,6-trihydroxyxanthone exhibited much potent inhibitory activity toward rat brain mitochondrial MAO (type A). On the other hand, 1,3,7-trihydroxyxanthone showed great potency for inhibition of mouse liver mitochondrial MAO (type B). These results indicate that 1,3,6-trihydroxyxanthone and 1,3,7-trihydroxyxanthone were rather specific inhibitors of type A MAO and type B MAO, respectively. 1,3-Dihydroxy-6-alkoxyxanthones containing alkoxy residues with carbon number 1 to 8 were synthesized and compared for their inhibitory activity toward rat brain mitochondrial MAO. Among them, 6-ethoxy-, 6-propyloxy-, and 6-butyloxy-derivatives were potent inhibitors, and especially, 1,3-dihydroxy-6-propyloxyxanthone was the most inhibitory. Lineweaver–Burk plot analysis demonstrates that these xanthone derivatives inhibited MAO in a competitive and reversible manner. Spectroscopic examinations suggest that complex formation between the flavin moiety and a xanthone derivative could be involved at least partly in their inhibitory action.

Archive | 1988

Intermediates for synthesizing BH4 and its derivatives

Masayasu Kurono; Takehiko Susuki; Tomio Ogasawara; Nobuko Ohishi; Kunio Yagi

Archive | 1982

Polymer-metal complexes containing quaternary nitrogen atoms used in the treatment of hypercholesteremia

Masayasu Kurono; Osamu Nakagawa; Takafumi Iida; Yoshiro Ishiwata; Tomio Ogasawara; Meiji Kuwayama

Archive | 1982

Polymer-metal complexes containing quaternary nitrogen atoms, process for preparation thereof and pharmaceutical agents comprising the same

Masayasu Kurono; Osamu Nakagawa; Takafumi Iida; Yoshiro Ishiwata; Tomio Ogasawara; Meiji Kuwayama

Chemical & Pharmaceutical Bulletin | 1990

DESIGN AND SYNTHESIS OF AN OPIOID RECEPTOR PROBE : MODE OF BINDING OF S-ACTIVATED (-)-6β-SULFHYDRYLDIHYDROMORPHINE WITH THE SH GROUP IN THE μ-OPIOID RECEPTOR

Ken Kanematsu; Ryo Naito; Yasuyuki Shimohigashi; Motonori Ohno; Tomio Ogasawara; Masayasu Kurono; Kunio Yagi

Biochemical and Biophysical Research Communications | 1987

Interaction of dimers of inactive enkephalin fragments with μ opiate receptors

Yasuyuki Shimohigashi; Tomio Ogasawara; Takuya Koshizaka; Michinori Waki; Tetsuo Kato; Nobuo Izumiya; Masayasu Kurono; Kunio Yagi

Archive | 1988

Intermediates for synthesizing 5,6,7,8-tetrahydro-L-erythro-biopterin and its derivatives

Masayasu Kurono; Takehiko Suzuki; Tomio Ogasawara; Nobuko Ohishi; Kunio Yagi

Biological & Pharmaceutical Bulletin | 1994

Pharmacodynamics and Tumoricidal Effect of Adriamycin Entrapped in Ceramide Sulfate-Containing Liposomes

Hitoshi Noda; Tomio Ogasawara; Takafumi Iida; Hidefumi Yamakawa; Hisashi Sanwa Kagak Michishita; Takahiko Mitani; Masayasu Kurono; Kunio Yagi

Journal of Clinical Biochemistry and Nutrition | 1991

Cholesterol Sulfate-Containing Liposomes Entrapping Adriamycin. Pharmacokinetics and Antineoplastic Effect.

Hitoshi Noda; Tomio Ogasawara; Hidefumi Yamakawa; Takafumi Iida; Masayasu Kurono; Kunio Yagi

Journal of Clinical Biochemistry and Nutrition | 1991

Preparation and Some Properties of Cholesterol Sulfate-Containing Liposomes Entrapping Adriamycin

Hitoshi Noda; Tomio Ogasawara; Hidefumi Yamakawa; Takafumi Iida; Masayasu Kurono; Kunio Yagi

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