Tomislav D. Zbozinek

The effect of positive mood induction on reducing reinstatement fear: Relevance for long term outcomes of exposure therapy.

While exposure therapy is effective in treating anxiety, fear can return after exposure. Return of fear can be understood through mechanisms of extinction learning. One form of return of fear is reinstatement, or, the fear that results from an unsignaled unconditional stimulus (US) presentation after extinction. Though the conditional response (CR; e.g., fear) typically reduces during extinction, the excitatory conditional stimulus (CS+) valence remains negative. The more negative the CS+ valence after the end of extinction, the greater the fear at reinstatement. The current study evaluated the degree to which positive mood induction (positive imagery training; PIT) compared to control (positive verbal training; PVT) before extinction a) decreased CS+ negative valence during extinction and b) reduced reinstatement fear. Compared to PVT, PIT a) increased positive affect, b) decreased post-extinction CS+ negative valence, and c) reduced reinstatement responding as measured by eye blink startle reflex (when shock was used at reinstatement) and self-report fear (regardless of reinstatement US type). Results suggest that increasing positive affect prior to exposure therapy could reduce relapse through reinstatement.

Post-extinction conditional stimulus valence predicts reinstatement fear: Relevance for long-term outcomes of exposure therapy

Exposure therapy for anxiety disorders is translated from fear conditioning and extinction. While exposure therapy is effective in treating anxiety, fear sometimes returns after exposure. One pathway for return of fear is reinstatement: unsignaled unconditional stimuli following completion of extinction. The present study investigated the extent to which valence of the conditional stimulus (CS+) after extinction predicts return of CS+ fear after reinstatement. Participants (N = 84) engaged in a differential fear conditioning paradigm and were randomised to reinstatement or non-reinstatement. We hypothesised that more negative post-extinction CS+ valence would predict higher CS+ fear after reinstatement relative to non-reinstatement and relative to extinction retest. Results supported the hypotheses and suggest that strategies designed to decrease negative valence of the CS+ may reduce the return of fear via reinstatement following exposure therapy.

Positive affect predicts less reacquisition of fear: relevance for long-term outcomes of exposure therapy

ABSTRACT Much emphasis in fear conditioning research is placed on understanding extinction learning, partly because of its application in treating anxiety disorders. Return of fear after extinction is a problem affecting long-term maintenance of treatment gains. The present study evaluated whether positive affect (PA) is associated with lower rates of reacquisition, or, an increase in fear following re-pairings of the conditional stimulus (CS+) and unconditional stimulus (US; e.g. electric shock) after extinction. Results showed that higher PA before and after extinction was associated with less CS+ fear during reacquisition as measured by skin conductance arousal and US expectancy. Conversely, negative affect was not associated with reacquisition of fear using any measure. These results provide implications for reducing reacquisition with exposure therapy for anxiety disorders.

The role of positive affect in enhancing extinction learning and exposure therapy for anxiety disorders

Although exposure is a valid treatment for anxiety disorders, efforts are being made to improve its overall effectiveness. The present article discusses one potential method of optimizing extinction learning and exposure therapy: increasing positive affect. The effect of positive affect on learning is discussed in regards to various components of learning, including attention, encoding, rehearsal, consolidation, retrieval, and stimulus valence. These effects are then discussed specifically with extinction learning and exposure therapy. The authors conclude that increasing positive affect during exposures may enhance exposure therapy via various these learning mechanisms but that this awaits further testing.

Optimierung expositionsbasierter Therapie@@@Maximizing exposure therapy: Ein Ansatz des inhibitorischen Lernens@@@An inhibitory learning approach

ZusammenfassungExposition ist eine wirksame Behandlung bei Angststörungen, jedoch zeigt eine substanzielle Anzahl von Klienten keine signifikante Symptomreduktion oder ein Wiederkehren der Angst. Es wird angenommen, dass ängstliche Personen Defizite in grundlegenden Mechanismen der Expositionstherapie, wie dem inhibitorischen Lernen, aufweisen. Ein gezieltes Ansprechen dieser Defizite könnte demnach die Wirksamkeit von Exposition optimieren. Allerdings fehlen bisher Vorschläge zur konkreten Umsetzung in der Praxis. Dieser Beitrag verdeutlicht anhand verschiedener Strategien, wie das Modell zur Optimierung der Behandlung von Angststörungen praktisch umsetzbar ist. Die vorgeschlagenen Strategien unterscheiden sich hierbei von einem reinen habituationsbasierten Ansatz oder kognitiven Ansätzen zur Widerlegung von Überzeugungen. Die Strategien umfassen: 1) das Widerlegen angstbezogener Erwartungen, 2) vertiefte Extinktion, 3) Extinktion mit gelegentlicher Verstärkung, 4) Entfernen von Sicherheitssignalen, 5) Variabilität, 6) Erinnerungsreize, 7) multiple Kontexte und 8) affektives Labeling. Durch Fallbeispiele wird die Anwendung dieser Strategien bei verschiedenen Angststörungen illustriert.AbstractExposure is an effective approach for treating anxiety disorders, although a substantial number of individuals fail to benefit or experience a return of fear. Research results suggest that anxious individuals show deficits in the mechanisms underlying exposure therapy, such as inhibitory learning. Targeting these processes may help improve the efficacy of exposure; however, there has been little discussion of how to implement this model in clinical practice. The primary aim of this paper is to provide examples to clinicians for how to apply this model to optimize exposure therapy, in ways that distinguish it from a fear habituation approach and a belief disconfirmation approach. Optimization strategies include (1) expectancy violation, (2) deepened extinction, (3) occasional reinforced extinction, (4) removal of safety signals, (5) variability, (6) retrieval cues, (7) multiple contexts and (8) affect labeling. Case studies illustrate methods of applying these techniques with a variety of anxiety disorders.

Maximizing exposure therapy An inhibitory learning approach

ZusammenfassungExposition ist eine wirksame Behandlung bei Angststörungen, jedoch zeigt eine substanzielle Anzahl von Klienten keine signifikante Symptomreduktion oder ein Wiederkehren der Angst. Es wird angenommen, dass ängstliche Personen Defizite in grundlegenden Mechanismen der Expositionstherapie, wie dem inhibitorischen Lernen, aufweisen. Ein gezieltes Ansprechen dieser Defizite könnte demnach die Wirksamkeit von Exposition optimieren. Allerdings fehlen bisher Vorschläge zur konkreten Umsetzung in der Praxis. Dieser Beitrag verdeutlicht anhand verschiedener Strategien, wie das Modell zur Optimierung der Behandlung von Angststörungen praktisch umsetzbar ist. Die vorgeschlagenen Strategien unterscheiden sich hierbei von einem reinen habituationsbasierten Ansatz oder kognitiven Ansätzen zur Widerlegung von Überzeugungen. Die Strategien umfassen: 1) das Widerlegen angstbezogener Erwartungen, 2) vertiefte Extinktion, 3) Extinktion mit gelegentlicher Verstärkung, 4) Entfernen von Sicherheitssignalen, 5) Variabilität, 6) Erinnerungsreize, 7) multiple Kontexte und 8) affektives Labeling. Durch Fallbeispiele wird die Anwendung dieser Strategien bei verschiedenen Angststörungen illustriert.AbstractExposure is an effective approach for treating anxiety disorders, although a substantial number of individuals fail to benefit or experience a return of fear. Research results suggest that anxious individuals show deficits in the mechanisms underlying exposure therapy, such as inhibitory learning. Targeting these processes may help improve the efficacy of exposure; however, there has been little discussion of how to implement this model in clinical practice. The primary aim of this paper is to provide examples to clinicians for how to apply this model to optimize exposure therapy, in ways that distinguish it from a fear habituation approach and a belief disconfirmation approach. Optimization strategies include (1) expectancy violation, (2) deepened extinction, (3) occasional reinforced extinction, (4) removal of safety signals, (5) variability, (6) retrieval cues, (7) multiple contexts and (8) affect labeling. Case studies illustrate methods of applying these techniques with a variety of anxiety disorders.